FLOT1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FLOT1_MOUSE
• UniProt AC: O08917
• Protein Name: Flotillin-1
• Gene Name: Flot1
• Organism: Mus musculus (Mouse).
• Sequence Length: 428
• Subcellular Localization: Cell membrane ; Peripheral membrane protein . Endosome . Membrane, caveola ; Peripheral membrane protein . Melanosome . Membrane raft . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (By similarity). Membrane-associa
• Protein Description: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles..
• Protein Sequence: MFFTCGPNEAMVVSGFCRSPPVMVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHGVPISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQCLSEIEMAKAQRDYELKKATYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYRLERLAEAEKAQLIMQAEAEAESVRMRGEAEAFAIGARARAEAEQMAKKAEAFQMYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILSRLPESVERLTGVSISQVNHNKPLRTA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	S-palmitoylation	---MFFTCGPNEAMV ---CCCCCCCCCEEE	7.83	28680068
17	S-palmitoylation	AMVVSGFCRSPPVMV EEEEECCCCCCCEEE	4.86	28680068
19	Phosphorylation	VVSGFCRSPPVMVAG EEECCCCCCCEEEEC	34.43	21743459
34	S-palmitoylation	GRVFVLPCIQQIQRI CEEEEEHHHHHHHHC	3.71	28526873
78	Ubiquitination	VKIQGQNKEMLAAAC EEECCCCHHHHHHHH	36.29	22790023
85	S-palmitoylation	KEMLAAACQMFLGKT HHHHHHHHHHHCCCC	2.30	28526873
160	Phosphorylation	DIHDDQDYLHSLGKA CCCCCCHHHHHCCCH	10.73	29514104
163	Phosphorylation	DDQDYLHSLGKARTA CCCHHHHHCCCHHCH	35.90	26370283
203	S-palmitoylation	QEKVSAQCLSEIEMA HHHHHHHHHHHHHHH	4.52	28526873
216	Phosphorylation	MAKAQRDYELKKATY HHHHHHCHHHHHCEE	25.91	29514104
238	Phosphorylation	RAQADLAYQLQVAKT HHHHHHHHHHHHHHH	19.63	29514104
315	Phosphorylation	QAEAEAESVRMRGEA HHHHHHHHHHHHHHH	23.28	29899451
382	Phosphorylation	ANKITLVSSGSGTMG CCEEEEEECCCCCCC	31.90	26643407
383	Phosphorylation	NKITLVSSGSGTMGA CEEEEEECCCCCCCC	29.51	26824392
385	Phosphorylation	ITLVSSGSGTMGAAK EEEEECCCCCCCCHH	32.79	25521595
387	Phosphorylation	LVSSGSGTMGAAKVT EEECCCCCCCCHHHH	17.71	26643407
392	Ubiquitination	SGTMGAAKVTGEVLD CCCCCCHHHHHHHHH	39.53	22790023
407	Phosphorylation	ILSRLPESVERLTGV HHHCCCHHHHHHHCC	27.60	-
423	Ubiquitination	ISQVNHNKPLRTA-- HHHCCCCCCCCCC--	37.57	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FLOT1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FLOT1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FLOT1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACTG_HUMAN	ACTG1	physical	26496610
VATA_HUMAN	ATP6V1A	physical	26496610
DYST_HUMAN	DST	physical	26496610
CAZA2_HUMAN	CAPZA2	physical	26496610
CAPZB_HUMAN	CAPZB	physical	26496610
CD44_HUMAN	CD44	physical	26496610
CLCN7_HUMAN	CLCN7	physical	26496610
DREB_HUMAN	DBN1	physical	26496610
DSG2_HUMAN	DSG2	physical	26496610
STOM_HUMAN	STOM	physical	26496610
EPS15_HUMAN	EPS15	physical	26496610
FLII_HUMAN	FLII	physical	26496610
FLNA_HUMAN	FLNA	physical	26496610
FLOT2_HUMAN	FLOT2	physical	26496610
GELS_HUMAN	GSN	physical	26496610
PLAK_HUMAN	JUP	physical	26496610
LMO7_HUMAN	LMO7	physical	26496610
MYO5A_HUMAN	MYO5A	physical	26496610
MYO5B_HUMAN	MYO5B	physical	26496610
MERL_HUMAN	NF2	physical	26496610
PROF1_HUMAN	PFN1	physical	26496610
SPG7_HUMAN	SPG7	physical	26496610
SPTN1_HUMAN	SPTAN1	physical	26496610
SPTB2_HUMAN	SPTBN1	physical	26496610
ST5_HUMAN	ST5	physical	26496610
SVIL_HUMAN	SVIL	physical	26496610
TAF5_HUMAN	TAF5	physical	26496610
TFR1_HUMAN	TFRC	physical	26496610
TPM4_HUMAN	TPM4	physical	26496610
MKNK1_HUMAN	MKNK1	physical	26496610
RAI3_HUMAN	GPRC5A	physical	26496610
LRRF2_HUMAN	LRRFIP2	physical	26496610
XPR1_HUMAN	XPR1	physical	26496610
ABCG2_HUMAN	ABCG2	physical	26496610
ARP2_HUMAN	ACTR2	physical	26496610
FARP1_HUMAN	FARP1	physical	26496610
SPF27_HUMAN	BCAS2	physical	26496610
BASP1_HUMAN	BASP1	physical	26496610
AKAP2_HUMAN	AKAP2	physical	26496610
SYNPO_HUMAN	SYNPO	physical	26496610
COBL_HUMAN	COBL	physical	26496610
COR1C_HUMAN	CORO1C	physical	26496610
ZDHC5_HUMAN	ZDHHC5	physical	26496610
PKHG3_HUMAN	PLEKHG3	physical	26496610
RGAP1_HUMAN	RACGAP1	physical	26496610
TMOD3_HUMAN	TMOD3	physical	26496610
LIMA1_HUMAN	LIMA1	physical	26496610
TRPM7_HUMAN	TRPM7	physical	26496610
LTOR1_HUMAN	LAMTOR1	physical	26496610
BMP2K_HUMAN	BMP2K	physical	26496610
KDIS_HUMAN	KIDINS220	physical	26496610
MICA3_HUMAN	MICAL3	physical	26496610
AFAP1_HUMAN	AFAP1	physical	26496610
INF2_HUMAN	INF2	physical	26496610
CYBR1_HUMAN	CYBRD1	physical	26496610
STON2_HUMAN	STON2	physical	26496610
NEXN_HUMAN	NEXN	physical	26496610
CAVN3_HUMAN	PRKCDBP	physical	26496610
MISP_HUMAN	MISP	physical	26496610
CAVN1_HUMAN	PTRF	physical	26496610
TPRN_HUMAN	TPRN	physical	26496610
MY18A_HUMAN	MYO18A	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.