GNAS1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GNAS1_MOUSE
• UniProt AC: Q6R0H7
• Protein Name: Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
• Gene Name: Gnas {ECO:0000312|MGI:MGI:95777}
• Organism: Mus musculus (Mouse).
• Sequence Length: 1133
• Subcellular Localization: Cell membrane ; Peripheral membrane protein . Apical cell membrane .
• Protein Description: Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as Gnas isoforms..
• Protein Sequence: MGMFNCLHGNNMSGQHDIPPEVGEQPEQEPLEAPGAAAPGAGAGPAEEMATEPDSEPSNNEPVPDETGSEISGPPEDSKSDIQSPCQAFEEVRVGGDYSPPPEEAMPFETQQPSLGDFWPTLEQPGPSGTPSGLQAFNPAILEPGTPTGASPGLGAYTPPPEEAMPFEFNEPAQGDHSQPPLQVPDLAPGGPEALVPRALPAEPGNIRFENAGFREDYSPPPEESVPFQVGGEEFGGDSPPPGLPRVIPQIGIGGEFPTVAVPSALCLAPAENAPPLWVRGAIDRPFREAVRSPPNFACDSPPMEITRPLLEIGRASIGVDDDTAVNMDSPPIASDGPPIEVSGAPDKSECAERPPVEREAAEMEGSPTTATAVEGKVPSPERGDGSSTQPEAMDAKPAPAAQAVSTGSDAGAPTDSAMLTDSQSDAGEDGTAPGTPSDLQSDPEELEEAPAVRADPDGGAAPVAPATPAESESEGSRDPAAEPASEAVPATTAESASGAAPVTQVEPAAAAVSATLAEPAARAAPITPKEPTTRAVPSARAHPAAGAVPGAPAMSASARAAAARAAYAGPLVWGARSLSATPAARASLPARAAAAARAASAARAVAAGRSASAAPSRAHLRPPSPEIQVADPPTPRPPPRPTAWPDKYERGRSCCRYEASSGICEIESSSDESEEGATGCFQWLLRRNRRPGLPRSHTVGSNPVRNFFTRAFGSCFGLSECTRSRSLSPGKAKDPMEERRKQMRKEAIEMREQKRADKKRSKLIDKQLEEEKMDYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPNFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
218	Phosphorylation	NAGFREDYSPPPEES CCCCCCCCCCCCHHC	20.51	24759943
239	Phosphorylation	GEEFGGDSPPPGLPR CCCCCCCCCCCCCCC	42.45	24759943
367	Phosphorylation	EAAEMEGSPTTATAV HHHHHCCCCCCCEEE	13.03	24759943
370	Phosphorylation	EMEGSPTTATAVEGK HHCCCCCCCEEEECC	25.95	29899451
380	Phosphorylation	AVEGKVPSPERGDGS EEECCCCCCCCCCCC	42.24	27841257
432	Phosphorylation	SDAGEDGTAPGTPSD CCCCCCCCCCCCHHH	41.84	-
436	Phosphorylation	EDGTAPGTPSDLQSD CCCCCCCCHHHHHCC	20.68	-
438	Phosphorylation	GTAPGTPSDLQSDPE CCCCCCHHHHHCCHH	51.28	-
528	Phosphorylation	AARAAPITPKEPTTR HHHCCCCCCCCCCCC	27.52	24759943
533	Phosphorylation	PITPKEPTTRAVPSA CCCCCCCCCCCCCCC	29.97	24759943
556	Phosphorylation	VPGAPAMSASARAAA CCCCCCCCHHHHHHH	22.60	24759943
558	Phosphorylation	GAPAMSASARAAAAR CCCCCCHHHHHHHHH	15.81	24759943
568	Phosphorylation	AAAARAAYAGPLVWG HHHHHHHHHCCCEEC	15.88	29514104
578	Phosphorylation	PLVWGARSLSATPAA CCEECCCCCCCCHHH	26.58	24759943
580	Phosphorylation	VWGARSLSATPAARA EECCCCCCCCHHHHH	31.20	24759943
582	Phosphorylation	GARSLSATPAARASL CCCCCCCCHHHHHCC	15.30	24759943
588	Phosphorylation	ATPAARASLPARAAA CCHHHHHCCHHHHHH	29.36	24719451
613	Phosphorylation	VAAGRSASAAPSRAH HHHCCCCCCCCCCCC	26.64	27841257
625	Phosphorylation	RAHLRPPSPEIQVAD CCCCCCCCCCCCCCC	37.54	-
699	Phosphorylation	PGLPRSHTVGSNPVR CCCCCCCCCCCCHHH	28.01	24719451
710	Phosphorylation	NPVRNFFTRAFGSCF CHHHHHHHHHHHHHH	19.56	24719451
715	Phosphorylation	FFTRAFGSCFGLSEC HHHHHHHHHHCHHHH	10.38	24759943
727	Phosphorylation	SECTRSRSLSPGKAK HHHHCCCCCCCCCCC	34.15	24759943
729	Phosphorylation	CTRSRSLSPGKAKDP HHCCCCCCCCCCCCH	32.62	23737553
790	Phosphorylation	LLLGAGESGKSTIVK HHHCCCCCCCHHHHE	51.07	20415495
792 (in isoform 2)	Phosphorylation	-	54.42	27841257
792 (in isoform 3)	Phosphorylation	-	54.42	27841257
793	Phosphorylation	GAGESGKSTIVKQMR CCCCCCCHHHHEEEE	27.22	29899451
794	Phosphorylation	AGESGKSTIVKQMRI CCCCCCHHHHEEEEE	33.02	-
821 (in isoform 3)	Phosphorylation	-	35.64	27841257
913	Glutathionylation	NEYQLIDCAQYFLDK CCCCHHHHHHHHHHH	1.70	24333276
913	S-palmitoylation	NEYQLIDCAQYFLDK CCCCHHHHHHHHHHH	1.70	28526873
916	Phosphorylation	QLIDCAQYFLDKIDV CHHHHHHHHHHHCHH	6.38	20415495
940	ADP-ribosylation	DQDLLRCRVLTSGIF CHHHHHHEEECCCCC	21.75	-
940	ADP-ribosylation	DQDLLRCRVLTSGIF CHHHHHHEEECCCCC	21.75	-
943	Phosphorylation	LLRCRVLTSGIFETK HHHHEEECCCCCEEE	23.27	29899451
944	Phosphorylation	LRCRVLTSGIFETKF HHHEEECCCCCEEEE	26.23	-
1050	Phosphorylation	GKSKIEDYFPEFARY CCHHHHHHCHHHHCC	14.29	-
1059	Phosphorylation	PEFARYTTPEDATPE HHHHCCCCCCCCCCC	18.75	-
1074	Phosphorylation	PGEDPRVTRAKYFIR CCCCCCCCEEEEEEC	26.62	-
1088	Phosphorylation	RDEFLRISTASGDGR CCCHHEEEECCCCCC	16.10	26643407
1089	Phosphorylation	DEFLRISTASGDGRH CCHHEEEECCCCCCC	23.59	26239621
1091	Phosphorylation	FLRISTASGDGRHYC HHEEEECCCCCCCCE	37.19	25521595
1097	Phosphorylation	ASGDGRHYCYPHFTC CCCCCCCCEECCCEE	7.72	23984901
1099	Phosphorylation	GDGRHYCYPHFTCAV CCCCCCEECCCEEEE	7.80	21183079
1103	Phosphorylation	HYCYPHFTCAVDTEN CCEECCCEEEECHHH	9.12	23984901
1104	S-palmitoylation	YCYPHFTCAVDTENI CEECCCEEEECHHHH	3.21	28680068
1130	Phosphorylation	QRMHLRQYELL---- HHHHHHHHHCC----	11.34	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GNAS1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GNAS1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GNAS1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GNAS1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.