dbPTM

GNAQ_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GNAQ_MOUSE
UniProt AC	P21279
Protein Name	Guanine nucleotide-binding protein G(q) subunit alpha
Gene Name	Gnaq
Organism	Mus musculus (Mouse).
Sequence Length	359
Subcellular Localization	Nucleus . Membrane . Nucleus membrane . Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes.
Protein Description	Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro)..
Protein Sequence	MTLESIMACCLSEEAKEARRINDEIERQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDKRGFTKLVYQNIFTAMQAMIRAMDTLKIPYKYEHNKAHAQLVREVDVEKVSAFENPYVDAIKSLWNDPGIQECYDRRREYQLSDSTKYYLNDLDRVADPSYLPTQQDVLRVRVPTTGIIEYPFDLQSVIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMYSHLVDYFPEYDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTLESIMAC ------CCHHHHHHH	38.95	25266776
9	S-palmitoylation	TLESIMACCLSEEAK CHHHHHHHHCCHHHH	1.01	28680068
10	S-palmitoylation	LESIMACCLSEEAKE HHHHHHHHCCHHHHH	3.21	28680068
52	Ubiquitination	LGTGESGKSTFIKQM HHCCCCCCHHHHEEE	56.45	-
57	Ubiquitination	SGKSTFIKQMRIIHG CCCHHHHEEEEEECC	33.57	-
65	Phosphorylation	QMRIIHGSGYSDEDK EEEEECCCCCCHHHC	22.01	29899451
67	Phosphorylation	RIIHGSGYSDEDKRG EEECCCCCCHHHCCC	18.04	25521595
98	Ubiquitination	IRAMDTLKIPYKYEH HHHHHHCCCCCCCCC	43.67	22790023
102	Ubiquitination	DTLKIPYKYEHNKAH HHCCCCCCCCCCHHH	38.52	22790023
107	Ubiquitination	PYKYEHNKAHAQLVR CCCCCCCHHHHHHHH	43.38	22790023
120	Ubiquitination	VREVDVEKVSAFENP HHCCCHHHHHCCCCH	41.14	22790023
122	Phosphorylation	EVDVEKVSAFENPYV CCCHHHHHCCCCHHH	38.00	22817900
158	Ubiquitination	YQLSDSTKYYLNDLD EECCCCCCCCCCCHH	35.53	22790023
209	Formation of an isopeptide bond	RMVDVGGQRSERRKW EEECCCCCCCHHHHH	39.54	23022564
252	Ubiquitination	ENRMEESKALFRTII CCCHHHHHHHHHHHH	53.00	-
345	Ubiquitination	RFVFAAVKDTILQLN HHHHHHHHHHHHHHC	44.41	-
350	Phosphorylation	AVKDTILQLNLKEYN HHHHHHHHHCCHHCC	25.18	12799383
356	Phosphorylation	LQLNLKEYNLV---- HHHCCHHCCCC----	16.53	11994281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GNAQ_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GNAQ_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GNAQ_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of GNAQ_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GNAQ_MOUSE

Related Literatures of Post-Translational Modification

Palmitoylation
Reference	PubMed
"Palmitoylation is required for signaling functions and membraneattachment of Gq alpha and Gs alpha."; Wedegaertner P.B., Chu D.H., Wilson P.T., Levis M.J., Bourne H.R.; J. Biol. Chem. 268:25001-25008(1993). Cited for: PALMITOYLATION AT CYS-9 AND CYS-10, AND MUTAGENESIS OF CYS-9 ANDCYS-10.	8227063 [Abstract]