dbPTM

DLGP4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DLGP4_MOUSE
UniProt AC	B1AZP2
Protein Name	Disks large-associated protein 4
Gene Name	Dlgap4
Organism	Mus musculus (Mouse).
Sequence Length	992
Subcellular Localization	Membrane Peripheral membrane protein.
Protein Description	May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane (By similarity)..
Protein Sequence	MKGLGDSRPRHLSDSLDPPHEPLFAGPDRNPYLLSPTEAFAREARFPGQNTLPGDGLFPLNNQLPPPSSTFPRIHYNSHFEVPEESPFPSHAQATKINRLPANLLDQFEKQLPIHRDGFSTLQFPRGEAKARGESPGRIRHLVHSVQRLFFTKAPSMEGTAGKVGGNGSKKGGLEDGKGRRAKSKERAKAGEPKRRSRSNISGWWSSDDNLDGEGGAFRSGPASGLMTLGRQQERTQPRYFMHAYNTISGHMLKTTKNTTTELTAPPPPPAPPATCPSLGVGTDTNYVKRGSWSTLTLSHAHEVCQKTSATLDKSLLKSKSCHQGLAYHYLQVPGGGGEWSTTLLSPRDMDSTAEGPIPCRRMRSGSYIKAMGDEDSDESGGGSPKPSPKTAARRQSYLRATQQSLGEQSNPRRSLDRLDSVDMLLPSKCPSWEDDYNPISDSLNDSSCISQVFGQASLIPQLFGHDQQVREADLSDQYEAACESACSEAESTTAEALDLPLPSYFRSRSHSYLRAIQAGCSQEEDSVSLQSLSPPPSTGSLSNSRTLPSSSCLVAYKKTPPPVPPRTTSKPFISVTVQSSTESAQDTYLDSQDHKSEVTSQSGLSNSSDSLDSSTRPPSVTRGGITPGPEAPEPPPKHAALKSEQGTLTSSESHSEAIPKRKLSSIGIQVDCIQPVPKEEPSPATKFQSIGIQVEDDWRSSAPSHSMSSRRDTDSDTQDANDSSCKSSERSLPDCTSHPNSISIDAGPRQAPKIAQIKRNLSYGDNSDPALEASSLPPPDPWLETSSSSPAEPAQPGACRRDGYWFLKLLQAETERLEGWCCQMDKETKENNLSEEVLGKVLSAVGSAQLLMSQKFQQFRGLCEQNLNPDANPRPTAQDLAGFWDLLQLSIEDISMKFDELYHLKANSWQLVETPEKRKEEKKPPPPVPKKPAKSKAAVSRDKASDAGDKQRQEARKRLLAAKRAASVRQNSATESADSIEIYVPEAQTRL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	DSRPRHLSDSLDPPH CCCCCCCCCCCCCCC	21.01	27742792
15	Phosphorylation	RPRHLSDSLDPPHEP CCCCCCCCCCCCCCC	31.15	22817900
35	Phosphorylation	DRNPYLLSPTEAFAR CCCCCCCCHHHHHHH	27.47	22817900
37	Phosphorylation	NPYLLSPTEAFAREA CCCCCCHHHHHHHHC	36.25	28066266
120	Phosphorylation	PIHRDGFSTLQFPRG CCCCCCCCCEEECCC	33.46	22817900
121	Phosphorylation	IHRDGFSTLQFPRGE CCCCCCCCEEECCCC	23.47	29899451
126	Methylation	FSTLQFPRGEAKARG CCCEEECCCCHHHCC	57.80	58859373
135	Phosphorylation	EAKARGESPGRIRHL CHHHCCCCCHHHHHH	35.16	22817900
145	Phosphorylation	RIRHLVHSVQRLFFT HHHHHHHHHHHHHHC	16.68	29899451
156	Phosphorylation	LFFTKAPSMEGTAGK HHHCCCCCCCCCCCC	34.03	25521595
160	Phosphorylation	KAPSMEGTAGKVGGN CCCCCCCCCCCCCCC	20.94	22324799
170	Acetylation	KVGGNGSKKGGLEDG CCCCCCCCCCCCCCC	57.76	7712809
199	Phosphorylation	EPKRRSRSNISGWWS CCCCCCCCCCCCCCC	39.50	22324799
202	Phosphorylation	RRSRSNISGWWSSDD CCCCCCCCCCCCCCC	32.39	24925903
206	Phosphorylation	SNISGWWSSDDNLDG CCCCCCCCCCCCCCC	19.85	22324799
207	Phosphorylation	NISGWWSSDDNLDGE CCCCCCCCCCCCCCC	34.95	22324799
228	Phosphorylation	GPASGLMTLGRQQER CCCCCCCCCCCCCCC	30.97	28542873
290	Methylation	TDTNYVKRGSWSTLT CCCCCCCCCCCCCEE	34.04	24129315
292	Phosphorylation	TNYVKRGSWSTLTLS CCCCCCCCCCCEEHH	23.14	22817900
365	Phosphorylation	IPCRRMRSGSYIKAM CCCCCCCCCCCEEEC	23.81	23737553
367	Phosphorylation	CRRMRSGSYIKAMGD CCCCCCCCCEEECCC	25.57	29899451
368	Phosphorylation	RRMRSGSYIKAMGDE CCCCCCCCEEECCCC	15.23	29899451
377	Phosphorylation	KAMGDEDSDESGGGS EECCCCCCCCCCCCC	41.03	25521595
380	Phosphorylation	GDEDSDESGGGSPKP CCCCCCCCCCCCCCC	47.96	22324799
384	Phosphorylation	SDESGGGSPKPSPKT CCCCCCCCCCCCHHH	32.78	25521595
388	Phosphorylation	GGGSPKPSPKTAARR CCCCCCCCHHHHHHH	45.19	25521595
397	Phosphorylation	KTAARRQSYLRATQQ HHHHHHHHHHHHHHH	25.07	16452087
402	Phosphorylation	RQSYLRATQQSLGEQ HHHHHHHHHHHHHCC	22.25	22817900
405	Phosphorylation	YLRATQQSLGEQSNP HHHHHHHHHHCCCCC	28.64	25521595
410	Phosphorylation	QQSLGEQSNPRRSLD HHHHHCCCCCCCCCH	44.49	22324799
415	Phosphorylation	EQSNPRRSLDRLDSV CCCCCCCCCHHHHHC	35.58	25521595
421	Phosphorylation	RSLDRLDSVDMLLPS CCCHHHHHCCCCCCC	25.30	25521595
485	Phosphorylation	QYEAACESACSEAES HHHHHHHHHCHHCHH	34.16	29899451
488	Phosphorylation	AACESACSEAESTTA HHHHHHCHHCHHCHH	39.29	29899451
493	Phosphorylation	ACSEAESTTAEALDL HCHHCHHCHHHHHCC	22.87	29899451
494	Phosphorylation	CSEAESTTAEALDLP CHHCHHCHHHHHCCC	31.60	29899451
508	Phosphorylation	PLPSYFRSRSHSYLR CCCHHHHCCCHHHHH	28.39	22817900
510	Phosphorylation	PSYFRSRSHSYLRAI CHHHHCCCHHHHHHH	20.31	29899451
512	Phosphorylation	YFRSRSHSYLRAIQA HHHCCCHHHHHHHHC	27.40	29899451
522	Phosphorylation	RAIQAGCSQEEDSVS HHHHCCCCCCCCCCC	39.44	25293948
527	Phosphorylation	GCSQEEDSVSLQSLS CCCCCCCCCCCCCCC	19.51	25293948
529	Phosphorylation	SQEEDSVSLQSLSPP CCCCCCCCCCCCCCC	25.33	25293948
532	Phosphorylation	EDSVSLQSLSPPPST CCCCCCCCCCCCCCC	35.79	25293948
534	Phosphorylation	SVSLQSLSPPPSTGS CCCCCCCCCCCCCCC	40.38	22817900
538	Phosphorylation	QSLSPPPSTGSLSNS CCCCCCCCCCCCCCC	51.69	25293948
539	Phosphorylation	SLSPPPSTGSLSNSR CCCCCCCCCCCCCCC	36.24	25293948
541	Phosphorylation	SPPPSTGSLSNSRTL CCCCCCCCCCCCCCC	28.81	30635358
543	Phosphorylation	PPSTGSLSNSRTLPS CCCCCCCCCCCCCCC	34.16	30635358
545	Phosphorylation	STGSLSNSRTLPSSS CCCCCCCCCCCCCCC	24.22	30635358
547	O-linked_Glycosylation	GSLSNSRTLPSSSCL CCCCCCCCCCCCCEE	42.73	55413673
558	Acetylation	SSCLVAYKKTPPPVP CCEEEEEECCCCCCC	40.20	19847489
560	Phosphorylation	CLVAYKKTPPPVPPR EEEEEECCCCCCCCC	36.55	25521595
568	Phosphorylation	PPPVPPRTTSKPFIS CCCCCCCCCCCCEEE	40.99	23375375
569	Phosphorylation	PPVPPRTTSKPFISV CCCCCCCCCCCEEEE	35.71	22807455
570	Phosphorylation	PVPPRTTSKPFISVT CCCCCCCCCCEEEEE	37.40	23375375
580	Phosphorylation	FISVTVQSSTESAQD EEEEEEECCCCCHHH	34.59	22817900
581	Phosphorylation	ISVTVQSSTESAQDT EEEEEECCCCCHHHH	21.07	22817900
582	Phosphorylation	SVTVQSSTESAQDTY EEEEECCCCCHHHHC	38.92	19060867
584	Phosphorylation	TVQSSTESAQDTYLD EEECCCCCHHHHCCC	31.17	22807455
589	Phosphorylation	TESAQDTYLDSQDHK CCCHHHHCCCCCCHH	19.46	22817900
600	Phosphorylation	QDHKSEVTSQSGLSN CCHHHHHHCCCCCCC	19.59	25619855
601	Phosphorylation	DHKSEVTSQSGLSNS CHHHHHHCCCCCCCC	27.76	25619855
603	Phosphorylation	KSEVTSQSGLSNSSD HHHHHCCCCCCCCCC	41.28	25619855
606	Phosphorylation	VTSQSGLSNSSDSLD HHCCCCCCCCCCCCC	37.89	25619855
608	Phosphorylation	SQSGLSNSSDSLDSS CCCCCCCCCCCCCCC	31.95	25619855
609	Phosphorylation	QSGLSNSSDSLDSST CCCCCCCCCCCCCCC	35.15	25619855
611	Phosphorylation	GLSNSSDSLDSSTRP CCCCCCCCCCCCCCC	35.70	25619855
614	Phosphorylation	NSSDSLDSSTRPPSV CCCCCCCCCCCCCCC	38.61	25619855
615	Phosphorylation	SSDSLDSSTRPPSVT CCCCCCCCCCCCCCC	28.27	25619855
616	Phosphorylation	SDSLDSSTRPPSVTR CCCCCCCCCCCCCCC	51.66	25619855
620	Phosphorylation	DSSTRPPSVTRGGIT CCCCCCCCCCCCCCC	38.51	25619855
622	Phosphorylation	STRPPSVTRGGITPG CCCCCCCCCCCCCCC	28.12	25619855
644	Phosphorylation	PKHAALKSEQGTLTS CCCCCCCCCCCCCCC	35.68	29899451
650	Phosphorylation	KSEQGTLTSSESHSE CCCCCCCCCCCCHHC	30.00	29899451
651	Phosphorylation	SEQGTLTSSESHSEA CCCCCCCCCCCHHCC	34.91	22807455
652	Phosphorylation	EQGTLTSSESHSEAI CCCCCCCCCCHHCCC	37.57	19060867
654	Phosphorylation	GTLTSSESHSEAIPK CCCCCCCCHHCCCCC	33.97	29899451
656	Phosphorylation	LTSSESHSEAIPKRK CCCCCCHHCCCCCHH	37.69	21082442
665	Phosphorylation	AIPKRKLSSIGIQVD CCCCHHHHHCCEEEE	23.97	25521595
665 (in isoform 2)	Phosphorylation	-	23.97	21183079
666	Phosphorylation	IPKRKLSSIGIQVDC CCCHHHHHCCEEEEE	34.96	22942356
666 (in isoform 2)	Phosphorylation	-	34.96	21183079
676 (in isoform 2)	Phosphorylation	-	25.19	29899451
678 (in isoform 2)	Phosphorylation	-	45.05	29899451
681 (in isoform 2)	Phosphorylation	-	58.15	25521595
683	Phosphorylation	PVPKEEPSPATKFQS CCCCCCCCCCCCCCC	30.37	25521595
702 (in isoform 2)	Phosphorylation	-	35.31	-
707	Phosphorylation	RSSAPSHSMSSRRDT HHCCCCCCCCCCCCC	25.38	-
709	Phosphorylation	SAPSHSMSSRRDTDS CCCCCCCCCCCCCCC	24.57	23375375
710	Phosphorylation	APSHSMSSRRDTDSD CCCCCCCCCCCCCCC	23.77	-
714	Phosphorylation	SMSSRRDTDSDTQDA CCCCCCCCCCCCCCC	35.27	25521595
716	Phosphorylation	SSRRDTDSDTQDAND CCCCCCCCCCCCCCH	44.65	25521595
718	Phosphorylation	RRDTDSDTQDANDSS CCCCCCCCCCCCHHH	32.09	20415495
724	Phosphorylation	DTQDANDSSCKSSER CCCCCCHHHCCCCCC	37.13	20415495
725	Phosphorylation	TQDANDSSCKSSERS CCCCCHHHCCCCCCC	28.55	20415495
728	Phosphorylation	ANDSSCKSSERSLPD CCHHHCCCCCCCCCC	41.58	29899451
732	Phosphorylation	SCKSSERSLPDCTSH HCCCCCCCCCCCCCC	39.95	22817900
736	Glutathionylation	SERSLPDCTSHPNSI CCCCCCCCCCCCCCE	3.87	24333276
737	Phosphorylation	ERSLPDCTSHPNSIS CCCCCCCCCCCCCEE	37.13	28066266
738	Phosphorylation	RSLPDCTSHPNSISI CCCCCCCCCCCCEEE	43.19	28066266
742	Phosphorylation	DCTSHPNSISIDAGP CCCCCCCCEEECCCC	23.36	24719451
744	Phosphorylation	TSHPNSISIDAGPRQ CCCCCCEEECCCCCC	17.78	22817900
763	Phosphorylation	AQIKRNLSYGDNSDP HHHHHHHCCCCCCCH	30.53	22942356
764	Phosphorylation	QIKRNLSYGDNSDPA HHHHHHCCCCCCCHH	31.50	26643407
768	Phosphorylation	NLSYGDNSDPALEAS HHCCCCCCCHHHHHH	50.11	26643407
775	Phosphorylation	SDPALEASSLPPPDP CCHHHHHHCCCCCCC	24.04	25293948
776	Phosphorylation	DPALEASSLPPPDPW CHHHHHHCCCCCCCC	52.52	25293948
786	Phosphorylation	PPDPWLETSSSSPAE CCCCCCCCCCCCCCC	31.57	25293948
787	Phosphorylation	PDPWLETSSSSPAEP CCCCCCCCCCCCCCC	20.88	25293948
788	Phosphorylation	DPWLETSSSSPAEPA CCCCCCCCCCCCCCC	42.10	25293948
789	Phosphorylation	PWLETSSSSPAEPAQ CCCCCCCCCCCCCCC	39.86	25293948
790	Phosphorylation	WLETSSSSPAEPAQP CCCCCCCCCCCCCCC	30.03	25293948
827	Acetylation	GWCCQMDKETKENNL HHHHCCCHHHHHCCC	63.04	22826441
841	Acetylation	LSEEVLGKVLSAVGS CCHHHHHHHHHHHHH	35.52	19844823
856	Acetylation	AQLLMSQKFQQFRGL HHHHHHHHHHHHHCH	37.52	19844835
909	Phosphorylation	LYHLKANSWQLVETP HHHHHCCCEEEECCH	22.51	23984901
915	Phosphorylation	NSWQLVETPEKRKEE CCEEEECCHHHHHHC	29.30	25521595
946	Phosphorylation	AVSRDKASDAGDKQR HHCHHHHCHHCHHHH	33.46	24899341
968	Phosphorylation	LAAKRAASVRQNSAT HHHHHHHHHHHCCCC	19.49	23608596
973	Phosphorylation	AASVRQNSATESADS HHHHHHCCCCCCCCC	28.38	25521595
975	Phosphorylation	SVRQNSATESADSIE HHHHCCCCCCCCCEE	30.23	25521595
977	Phosphorylation	RQNSATESADSIEIY HHCCCCCCCCCEEEE	32.78	24723360
980	Phosphorylation	SATESADSIEIYVPE CCCCCCCCEEEECCH	23.10	23684622
984	Phosphorylation	SADSIEIYVPEAQTR CCCCEEEECCHHHHC	9.36	26643407
990	Phosphorylation	IYVPEAQTRL----- EECCHHHHCC-----	100.00	23429704

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DLGP4_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DLGP4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DLGP4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DMD_HUMAN	DMD	physical	26496610
TYK2_HUMAN	TYK2	physical	26496610
ZNF35_HUMAN	ZNF35	physical	26496610
MCA3_HUMAN	EEF1E1	physical	26496610
TBB4B_HUMAN	TUBB4B	physical	26496610
TRM6_HUMAN	TRMT6	physical	26496610
FGD6_HUMAN	FGD6	physical	26496610

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DLGP4_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-665, AND MASSSPECTROMETRY.	19367708 [Abstract]
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-421 AND THR-915, ANDMASS SPECTROMETRY.	17114649 [Abstract]
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-367; SER-377; SER-397AND SER-512, AND MASS SPECTROMETRY.	16452087 [Abstract]
"Phosphoproteomic analysis of the developing mouse brain."; Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.; Mol. Cell. Proteomics 3:1093-1101(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-973, AND MASSSPECTROMETRY.	15345747 [Abstract]