dbPTM

FGD6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FGD6_HUMAN
UniProt AC	Q6ZV73
Protein Name	FYVE, RhoGEF and PH domain-containing protein 6
Gene Name	FGD6
Organism	Homo sapiens (Human).
Sequence Length	1430
Subcellular Localization	Cytoplasm . Cytoplasm, cytoskeleton .
Protein Description	May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity)..
Protein Sequence	MTSAAEIKKPPVAPKPKFVVANNKPAPPPIAPKPDIVISSVPQSTKKMKPAIAPKPKVLKTSPVREIGQSPSRKIMLNLEGHKQELAESTDNFNCKYEGNQSNDYISPMCSCSSECIHKLGHRENLCVKQLVLEPLEMNENLENSKIDETLTIKTRSKCDLYGEKAKNQGGVVLKASVLEEELKDALIHQMPPFISAQKHRPTDSPEMNGGCNSNGQFRIEFADLSPSPSSFEKVPDHHSCHLQLPSDECEHFETCQDDSEKSNNCFQSSELEALENGKRSTLISSDGVSKKSEVKDLGPLEIHLVPYTPKFPTPKPRKTRTARLLRQKCVDTPSESTEEPGNSDSSSSCLTENSLKINKISVLHQNVLCKQEQVDKMKLGNKSELNMESNSDAQDLVNSQKAMCNETTSFEKMAPSFDKDSNLSSDSTTVDGSSMSLAVDEGTGFIRCTVSMSLPKQLKLTCNEHLQSGRNLGVSAPQMQKESVIKEENSLRIVPKKPQRHSLPATGVLKKAASEELLEKSSYPSSEEKSSEKSLERNHLQHLCAQNRGVSSSFDMPKRASEKPVWKLPHPILPFSGNPEFLKSVTVSSNSEPSTALTKPRAKSLSAMDVEKCTKPCKDSTKKNSFKKLLSMKLSICFMKSDFQKFWSKSSQLGDTTTGHLSSGEQKGIESDWQGLLVGEEKRSKPIKAYSTENYSLESQKKRKKSRGQTSAANGLRAESLDDQMLSRESSSQAPYKSVTSLCAPEYENIRHYEEIPEYENLPFIMAIRKTQELEWQNSSSMEDADANVYEVEEPYEAPDGQLQLGPRHQHSSSGASQEEQNDLGLGDLPSDEEEIINSSDEDDVSSESSKGEPDPLEDKQDEDNGMKSKVHHIAKEIMSSEKVFVDVLKLLHIDFRDAVAHASRQLGKPVIEDRILNQILYYLPQLYELNRDLLKELEERMLHWTEQQRIADIFVKKGPYLKMYSTYIKEFDKNIALLDEQCKKNPGFAAVVREFEMSPRCANLALKHYLLKPVQRIPQYRLLLTDYLKNLIEDAGDYRDTQDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLNGHHEIVQPGRVFLKEGILMKLSRKVMQPRMFFLFNDALLYTTPVQSGMYKLNNMLSLAGMKVRKPTQEAYQNELKIESVERSFILSASSATERDEWLEAISRAIEEYAKKRITFCPSRSLDEADSENKEEVSPLGSKAPIWIPDTRATMCMICTSEFTLTWRRHHCRACGKIVCQACSSNKYGLDYLKNQPARVCEHCFQELQKLDHQHSPRIGSPGNHKSPSSALSSVLHSIPSGRKQKKIPAALKEVSANTEDSSMSGYLYRSKGNKKPWKHFWFVIKNKVLYTYAASEDVAALESQPLLGFTVIQVKDENSESKVFQLLHKNMLFYVFKAEDAHSAQKWIEAFQEGTIL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MTSAAEIKKP -----CCCHHHCCCC	37.02	-
44	Phosphorylation	VISSVPQSTKKMKPA EEECCCCCCCCCCCC	35.80	25627689
45	Phosphorylation	ISSVPQSTKKMKPAI EECCCCCCCCCCCCC	29.45	26853621
46	Acetylation	SSVPQSTKKMKPAIA ECCCCCCCCCCCCCC	57.00	26051181
61	Phosphorylation	PKPKVLKTSPVREIG CCCCCCCCCCCEECC	33.82	23403867
62	Phosphorylation	KPKVLKTSPVREIGQ CCCCCCCCCCEECCC	21.58	25159151
70	Phosphorylation	PVREIGQSPSRKIML CCEECCCCCCCCEEE	21.45	23403867
72	Phosphorylation	REIGQSPSRKIMLNL EECCCCCCCCEEECC	51.99	23403867
89	Phosphorylation	HKQELAESTDNFNCK HHHHHHHCCCCCCCE	35.14	25627689
90	Phosphorylation	KQELAESTDNFNCKY HHHHHHCCCCCCCEE	26.85	25627689
102	Phosphorylation	CKYEGNQSNDYISPM CEECCCCCCCCCCCC	35.35	29759185
105	Phosphorylation	EGNQSNDYISPMCSC CCCCCCCCCCCCCCC	13.93	27642862
111	Phosphorylation	DYISPMCSCSSECIH CCCCCCCCCCHHHHH	15.69	28348404
113	Phosphorylation	ISPMCSCSSECIHKL CCCCCCCCHHHHHHH	16.93	30576142
114	Phosphorylation	SPMCSCSSECIHKLG CCCCCCCHHHHHHHC	40.59	28348404
162	Phosphorylation	TRSKCDLYGEKAKNQ ECCCCCCCCHHCCCC	15.24	-
165	Acetylation	KCDLYGEKAKNQGGV CCCCCCHHCCCCCCE	61.37	20167786
177	Phosphorylation	GGVVLKASVLEEELK CCEEEEEHHHHHHHH	26.16	19664994
196	Phosphorylation	HQMPPFISAQKHRPT HHCCCCCCCCCCCCC	25.65	25159151
205	Phosphorylation	QKHRPTDSPEMNGGC CCCCCCCCCCCCCCC	25.82	28985074
226	Phosphorylation	RIEFADLSPSPSSFE EEEECCCCCCCCCCC	24.71	22199227
228	Phosphorylation	EFADLSPSPSSFEKV EECCCCCCCCCCCCC	33.76	22199227
230	Phosphorylation	ADLSPSPSSFEKVPD CCCCCCCCCCCCCCC	52.58	25159151
231	Phosphorylation	DLSPSPSSFEKVPDH CCCCCCCCCCCCCCC	40.59	25159151
281	Phosphorylation	ALENGKRSTLISSDG HHHCCCCCEEECCCC	30.93	-
285	Phosphorylation	GKRSTLISSDGVSKK CCCCEEECCCCCCCC	26.03	29396449
286	Phosphorylation	KRSTLISSDGVSKKS CCCEEECCCCCCCCH	31.24	29396449
290	Phosphorylation	LISSDGVSKKSEVKD EECCCCCCCCHHCCC	39.64	29396449
308	Phosphorylation	LEIHLVPYTPKFPTP EEEEEEECCCCCCCC	28.35	27642862
333	Phosphorylation	LRQKCVDTPSESTEE HHHHCCCCCCCCCCC	14.33	30576142
335	Phosphorylation	QKCVDTPSESTEEPG HHCCCCCCCCCCCCC	46.39	30576142
337	Phosphorylation	CVDTPSESTEEPGNS CCCCCCCCCCCCCCC	45.52	30576142
338	Phosphorylation	VDTPSESTEEPGNSD CCCCCCCCCCCCCCC	40.07	30576142
346	Phosphorylation	EEPGNSDSSSSCLTE CCCCCCCCCCCCCCC	31.76	30576142
408	Phosphorylation	QKAMCNETTSFEKMA HHHHHCCCCCHHHHC	17.47	23090842
409	Phosphorylation	KAMCNETTSFEKMAP HHHHCCCCCHHHHCC	25.82	23090842
410	Phosphorylation	AMCNETTSFEKMAPS HHHCCCCCHHHHCCC	38.54	21815630
417	Phosphorylation	SFEKMAPSFDKDSNL CHHHHCCCCCCCCCC	36.22	25056879
454	Phosphorylation	IRCTVSMSLPKQLKL EEEEEEECCCCCCEE	33.73	28348404
460	Methylation	MSLPKQLKLTCNEHL ECCCCCCEEHHHHHH	38.98	-
491	Phosphorylation	SVIKEENSLRIVPKK HHCCCCCCEEECCCC	23.46	27251275
503	Phosphorylation	PKKPQRHSLPATGVL CCCCCCCCCCCCCHH	37.93	23403867
507	Phosphorylation	QRHSLPATGVLKKAA CCCCCCCCCHHHHHH	26.36	23403867
511	Methylation	LPATGVLKKAASEEL CCCCCHHHHHHCHHH	37.65	-
512	Methylation	PATGVLKKAASEELL CCCCHHHHHHCHHHH	45.05	-
515	Phosphorylation	GVLKKAASEELLEKS CHHHHHHCHHHHHHC	36.14	25159151
552	Phosphorylation	CAQNRGVSSSFDMPK HHHCCCCCCCCCCCC	24.08	22777824
553	Phosphorylation	AQNRGVSSSFDMPKR HHCCCCCCCCCCCCC	32.39	25159151
554	Phosphorylation	QNRGVSSSFDMPKRA HCCCCCCCCCCCCCC	20.12	25159151
605	Phosphorylation	LTKPRAKSLSAMDVE CCCCCCCCCCCCCHH	26.94	29255136
607	Phosphorylation	KPRAKSLSAMDVEKC CCCCCCCCCCCHHHC	28.74	29255136
615	Phosphorylation	AMDVEKCTKPCKDST CCCHHHCCCCCCCCC	49.44	26074081
621	Phosphorylation	CTKPCKDSTKKNSFK CCCCCCCCCCCCCHH	27.85	26074081
622	Phosphorylation	TKPCKDSTKKNSFKK CCCCCCCCCCCCHHH	57.05	26074081
632	Phosphorylation	NSFKKLLSMKLSICF CCHHHHHHCHHHHHH	25.06	20068231
636	Phosphorylation	KLLSMKLSICFMKSD HHHHCHHHHHHCCHH	16.28	20068231
642	Phosphorylation	LSICFMKSDFQKFWS HHHHHCCHHHHHHHH	31.69	20068231
650	Ubiquitination	DFQKFWSKSSQLGDT HHHHHHHHCCCCCCC	44.73	33845483
651	Phosphorylation	FQKFWSKSSQLGDTT HHHHHHHCCCCCCCC	20.15	22777824
652	Phosphorylation	QKFWSKSSQLGDTTT HHHHHHCCCCCCCCC	32.91	25159151
663	Phosphorylation	DTTTGHLSSGEQKGI CCCCCCCCCCCCCCC	30.53	25627689
664	Phosphorylation	TTTGHLSSGEQKGIE CCCCCCCCCCCCCCC	53.35	-
683	Ubiquitination	GLLVGEEKRSKPIKA CEECCCCCCCCCCEE	58.64	29967540
691	Phosphorylation	RSKPIKAYSTENYSL CCCCCEECCCCCCCH	15.89	21945579
692	Phosphorylation	SKPIKAYSTENYSLE CCCCEECCCCCCCHH	33.82	21945579
693	Phosphorylation	KPIKAYSTENYSLES CCCEECCCCCCCHHH	18.64	21945579
696	Phosphorylation	KAYSTENYSLESQKK EECCCCCCCHHHHHH	14.38	21945579
697	Phosphorylation	AYSTENYSLESQKKR ECCCCCCCHHHHHHH	36.92	21945579
700	Phosphorylation	TENYSLESQKKRKKS CCCCCHHHHHHHHHH	53.22	21945579
707	Phosphorylation	SQKKRKKSRGQTSAA HHHHHHHHHCCCHHH	44.68	22210691
711	Phosphorylation	RKKSRGQTSAANGLR HHHHHCCCHHHHCCC	24.13	28102081
712	Phosphorylation	KKSRGQTSAANGLRA HHHHCCCHHHHCCCH	19.93	28102081
721	Phosphorylation	ANGLRAESLDDQMLS HHCCCHHHHCHHHHC	35.79	23927012
728	Phosphorylation	SLDDQMLSRESSSQA HHCHHHHCCCCCCCC	28.76	23403867
739	Phosphorylation	SSQAPYKSVTSLCAP CCCCCCCHHHHHCCC	25.45	27642862
741	Phosphorylation	QAPYKSVTSLCAPEY CCCCCHHHHHCCCCC	24.07	26356563
742	Phosphorylation	APYKSVTSLCAPEYE CCCCHHHHHCCCCCC	21.21	26356563
748	Phosphorylation	TSLCAPEYENIRHYE HHHCCCCCCCCCCHH	17.14	27259358
754	Phosphorylation	EYENIRHYEEIPEYE CCCCCCCHHHCCCCC	12.86	27259358
760	Phosphorylation	HYEEIPEYENLPFIM CHHHCCCCCCCCCEE	12.55	27259358
791	Phosphorylation	EDADANVYEVEEPYE HHCCCCEEEECCCEE	17.67	27642862
797	Phosphorylation	VYEVEEPYEAPDGQL EEEECCCEECCCCCC	28.18	22468782
813	Phosphorylation	LGPRHQHSSSGASQE CCCCCCCCCCCCCHH	21.45	22468782
814	Phosphorylation	GPRHQHSSSGASQEE CCCCCCCCCCCCHHH	30.57	22468782
869	Acetylation	QDEDNGMKSKVHHIA CCCCCCHHHHHHHHH	48.82	12650419
870	Phosphorylation	DEDNGMKSKVHHIAK CCCCCHHHHHHHHHH	30.90	26074081
871	Acetylation	EDNGMKSKVHHIAKE CCCCHHHHHHHHHHH	39.82	12650431
881	Phosphorylation	HIAKEIMSSEKVFVD HHHHHHHCCCHHHHH	40.79	26074081
882	Phosphorylation	IAKEIMSSEKVFVDV HHHHHHCCCHHHHHH	24.85	26074081
962	Phosphorylation	IFVKKGPYLKMYSTY HEECCCCCHHHHHHH	27.85	29759185
966	Phosphorylation	KGPYLKMYSTYIKEF CCCCHHHHHHHHHHH	9.04	29759185
967	Phosphorylation	GPYLKMYSTYIKEFD CCCHHHHHHHHHHHH	15.96	29759185
968	Phosphorylation	PYLKMYSTYIKEFDK CCHHHHHHHHHHHHH	16.27	22461510
969	Phosphorylation	YLKMYSTYIKEFDKN CHHHHHHHHHHHHHC	12.21	22461510
1040	Phosphorylation	LIEDAGDYRDTQDAL HHHHHCCCCCHHHHH	14.96	27067055
1191	Phosphorylation	EYAKKRITFCPSRSL HHHHHCCCCCCCCCC	24.18	23403867
1195	Phosphorylation	KRITFCPSRSLDEAD HCCCCCCCCCCCHHH	35.36	23403867
1197	Phosphorylation	ITFCPSRSLDEADSE CCCCCCCCCCHHHHC	44.50	30266825
1203	Phosphorylation	RSLDEADSENKEEVS CCCCHHHHCCCCCCC	50.55	23403867
1210	Phosphorylation	SENKEEVSPLGSKAP HCCCCCCCCCCCCCC	20.07	21815630
1214	Phosphorylation	EEVSPLGSKAPIWIP CCCCCCCCCCCEECC	33.07	24719451
1238	Phosphorylation	CTSEFTLTWRRHHCR ECCEEEEEEHHHHHC	17.54	-
1256	Phosphorylation	KIVCQACSSNKYGLD CEEEHHHHCCCCCHH	39.71	29083192
1257	Phosphorylation	IVCQACSSNKYGLDY EEEHHHHCCCCCHHH	36.91	29083192
1288	Phosphorylation	QKLDHQHSPRIGSPG HHCCCCCCCCCCCCC	14.87	25056879
1293	Phosphorylation	QHSPRIGSPGNHKSP CCCCCCCCCCCCCCH	27.54	28152594
1299	Phosphorylation	GSPGNHKSPSSALSS CCCCCCCCHHHHHHH	23.59	28152594
1301	Phosphorylation	PGNHKSPSSALSSVL CCCCCCHHHHHHHHH	35.02	28152594
1302	Phosphorylation	GNHKSPSSALSSVLH CCCCCHHHHHHHHHH	36.29	28152594
1305	Phosphorylation	KSPSSALSSVLHSIP CCHHHHHHHHHHHCC	20.37	22199227
1306	Phosphorylation	SPSSALSSVLHSIPS CHHHHHHHHHHHCCC	29.55	22199227
1310	Phosphorylation	ALSSVLHSIPSGRKQ HHHHHHHHCCCCCHH	31.84	22199227
1313	Phosphorylation	SVLHSIPSGRKQKKI HHHHHCCCCCHHCCC	49.95	25159151
1395	Ubiquitination	KDENSESKVFQLLHK CCCCCCCHHHHHHHH	42.91	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of FGD6_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FGD6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FGD6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KI13B_HUMAN	KIF13B	physical	27173435
CING_HUMAN	CGN	physical	27173435
ZBT21_HUMAN	ZBTB21	physical	27173435
CBY1_HUMAN	CBY1	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FGD6_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-721, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-515 AND SER-721, ANDMASS SPECTROMETRY.	18669648 [Abstract]