PPM1E_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPM1E_MOUSE
• UniProt AC: Q80TL0
• Protein Name: Protein phosphatase 1E
• Gene Name: Ppm1e
• Organism: Mus musculus (Mouse).
• Sequence Length: 749
• Subcellular Localization: Nucleus . Cytoplasm . A truncated form, major form, with the C-terminal part missing, is mostly found in the cytoplasm and a little in the nucleus. The full-length, minor form, is found in the nucleus.
• Protein Description: Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2. Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42 (By similarity). Dephosphorylates PRKAA2..
• Protein Sequence: MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPEPESEPEPEPEAELVAAEAAEASGEEPGEDAATVEATEEGEQDQDPEPEDEAVEEETATEGEEEEEEEAAAPGHSAVPPPPQPQLPPLPPLPRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARATSDEVLQSDLSAHCIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQIYYETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASVHLHVNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAEHKPYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLVASARDAGSSDNITVIVVFLRDMNKAVNVSEESEWTENSFQGGQEDGGDDKETHGECKRPWPQHQCSAPADLGYEGRVDSFTDRTSLSPGPQINVLEDPDYLDLTQIEASKPHSTQFLPPVEMIGPGAPKKDLNELIMEERSVKSSLPERSGAGEPRVSFNLGSTGQQICRMENLSPVSSGLENEQFKSRGKTASRLYHLRHHYSKRQRGFRFNPKFYSFLSAREPSHKIGISLSSLTRSGKRNKMLRSSLPWRENSWEGYSGNVKIRKRNDIPCPDFPWSYKI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
176	Phosphorylation	EVLQSDLSAHCIPKE HHHHHHHHHCCCCCC	22.43	29899451
197	Ubiquitination	TVEIETVKLARSVFS EEEEEHHHHHHHHHH	43.80	-
393	Phosphorylation	GAWRVNGSLSVSRAI ECCEECCEEEEHHHC	16.56	29899451
397	Phosphorylation	VNGSLSVSRAIGDAE ECCEEEEHHHCCCCC	16.78	21082442
495	Phosphorylation	MNKAVNVSEESEWTE CCCCCCCCCCCCCCC	30.37	25521595
498	Phosphorylation	AVNVSEESEWTENSF CCCCCCCCCCCCCCC	34.09	25521595
501	Phosphorylation	VSEESEWTENSFQGG CCCCCCCCCCCCCCC	22.64	20415495
504	Phosphorylation	ESEWTENSFQGGQED CCCCCCCCCCCCCCC	16.83	29899451
518	Phosphorylation	DGGDDKETHGECKRP CCCCCCCCCCCCCCC	40.70	29899451
532	Phosphorylation	PWPQHQCSAPADLGY CCCCCCCCCCCCCCC	30.62	25521595
539	Phosphorylation	SAPADLGYEGRVDSF CCCCCCCCCCCCCCC	23.62	27742792
545	Phosphorylation	GYEGRVDSFTDRTSL CCCCCCCCCCCCCCC	27.47	22324799
547	Phosphorylation	EGRVDSFTDRTSLSP CCCCCCCCCCCCCCC	28.64	22324799
609	Acetylation	IMEERSVKSSLPERS HHHHHHHHHCCCCCC	35.26	15624829
654	Phosphorylation	LENEQFKSRGKTASR CCCHHHHHCCCHHHH	47.78	19367708
658	Phosphorylation	QFKSRGKTASRLYHL HHHHCCCHHHHHHHH	32.46	28059163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PPM1E_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPM1E_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPM1E_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PPM1E_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.