KAD5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KAD5_MOUSE
• UniProt AC: Q920P5
• Protein Name: Adenylate kinase isoenzyme 5
• Gene Name: Ak5
• Organism: Mus musculus (Mouse).
• Sequence Length: 562
• Subcellular Localization: Cytoplasm .
• Protein Description: Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity..
• Protein Sequence: MNTNDAKEYLARRDIPQLFESLLNGLMCSKPEDPIEYLETCLQKVKELGGCDKVKWDTFVSQEKKTLPPLNGGQSRRSFLRNVMPENSNFPYRRYDRLPPIHQFSIESDTDLSETAELIEEYEVFDPTRPRPKIILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSASSNRKWSLIAKIITNGELAPQETTITEIKQKLMQIPDEEGIVIDGFPRDVAQALSFEDQICTPDLVVFLACANQRLKERLQKRAEQQGRPDDNLKATQRRLVNFKQNAAPLVKYFQEKGLIVTFDADRDEDAVFHDISVAVDSKLFPNKEAPMDSSDLDPSMMFDAGEIIDTGSDYDNQDDDQLNVFGEDTEGGFMEDLRKCKIIFLMGGPGSGKGTQCEKLAEKYGFTHLSTGELLRQELTSESERSKLIRDIMERGDLVPSGVVLELLKEAMVASLGNTKGFLIDGYPREVKQGEEFGRRIGDPHLVICMDCSADTMTNRLLQRSQSSQRGEDGAKSIAKRLEAYHRASIPVVTYYERKTQLRKVNAEGTPEQVFLQLCTAIDSVF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
78	Phosphorylation	NGGQSRRSFLRNVMP CCCHHHHHHHHHHCC	27.76	51459005
95	Phosphorylation	SNFPYRRYDRLPPIH CCCCCCCCCCCCCCC	9.09	20681895
105	Phosphorylation	LPPIHQFSIESDTDL CCCCCCCEECCCCCH	20.90	18850143
108	Phosphorylation	IHQFSIESDTDLSET CCCCEECCCCCHHHH	44.11	29899451
110	Phosphorylation	QFSIESDTDLSETAE CCEECCCCCHHHHHH	48.39	29899451
113	Phosphorylation	IESDTDLSETAELIE ECCCCCHHHHHHHHH	35.39	29899451
156	Phosphorylation	SLKIAERYGFQYISV HHHHHHHHCCCEEEH	17.50	51459001
181	Phosphorylation	ASSNRKWSLIAKIIT CCCCCCEEEEEEHHH	16.97	22817900
287	Ubiquitination	QNAAPLVKYFQEKGL HCHHHHHHHHHHCCE	48.29	27667366
503	Phosphorylation	RLLQRSQSSQRGEDG HHHHHHHHHHCCCHH	29.68	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KAD5_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KAD5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KAD5_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of KAD5_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.