dbPTM

NRCAM_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NRCAM_MOUSE
UniProt AC	Q810U4
Protein Name	Neuronal cell adhesion molecule
Gene Name	Nrcam
Organism	Mus musculus (Mouse).
Sequence Length	1256
Subcellular Localization	Cell membrane Single-pass type I membrane protein . Cell projection, axon . Secreted . Detected at nodes of Ranvier (PubMed:14602817, PubMed:20188654, PubMed:24719088).
Protein Description	Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. [PubMed: 11564762 Plays a role in mediating cell-cell contacts between Schwann cells and axons]
Protein Sequence	MQLKIMPKKKHLSAGGVPLILFLCQMISALDVPLDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGSGTLVINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKERLEPIVLQNGQSLVLPCRPPIGLPPAIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISLKVISVDELNDTIAANLSDTEFYGAKSSKERPPTFLTPEGNESHKEELRGNVLSLECIAEGLPTPIIYWIKEDGMLPANRTFYRNFKKTLQITHVSEADSGNYQCIAKNALGAVHHTISVTVKAAPYWIVAPQNLVLSPGENGTLICRANGNPKPRISWLTNGVPIEIALDDPSRKIDGDTIIFSNVQESSSAVYQCNASNKYGYLLANAFVNVLAEPPRILTSANTLYQVIANRPALLDCAFFGSPMPTIEWFKGTKGSALHEDIYVLHDNGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTRIIKQPEYAVVQRGSKVSFECRVKHDHTLIPTIMWLKDNGELPNDERFSTDKDHLVVSDVKDDDGGTYTCTANTTLDSASASAVLRVVAPTPTPAPIYDVPNPPFDLELTNQLDKSVQLTWTPGDDNNSPITKFIIEYEDAMHDAGLWRHQAEVSGTQTTAQLKLSPYVNYSFRVMAENSIGRSMPSEASEQYLTKAAEPDQNPMAVEGLGTEPDNLVITWKPLNGFQSNGPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALNDVGFAPEPAAVMGHSGEDLPMVAPGNVRVSVVNSTLAEVHWDPVPPKSVRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGTKTHGMLPGLQPYSHYALNVRVVNGKGEGPASTDRGFHTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSHPNGILTEYILQYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSVGPGSQITEEAITTVDEAGIPPPDVGAGKGKEEWRKEIVNGSRSFFGLKGLMPGTAYKVRVGAEGDSGFVSSEDVFETGPAMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGKYPVKEKEDAHADPEIQPMKEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGVNGQFNEDGSFIGQYSGKKEKEPAEGNESSEAPSPVNAMNSFV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
77	N-linked_Glycosylation	PSFSWTRNGTHFDID CCCCCCCCCCCCCCC	52.95	-
217	N-linked_Glycosylation	YICYARFNHTQTIQQ EEEEEECCCCCEECC	31.57	-
239	N-linked_Glycosylation	VISVDELNDTIAANL EEEHHHCCCEEECCC	42.19	-
245	N-linked_Glycosylation	LNDTIAANLSDTEFY CCCEEECCCCCCCCC	30.93	-
270	N-linked_Glycosylation	TFLTPEGNESHKEEL CEECCCCCHHHHHHH	46.03	-
308	N-linked_Glycosylation	EDGMLPANRTFYRNF CCCCCCCCHHHHHHH	41.40	-
371	N-linked_Glycosylation	LVLSPGENGTLICRA EEECCCCCCEEEEEC	55.45	-
410	Phosphorylation	SRKIDGDTIIFSNVQ CCCCCCCEEEECCCC	22.85	17242355
419	Phosphorylation	IFSNVQESSSAVYQC EECCCCCCCCCEEEE	16.70	17242355
420	Phosphorylation	FSNVQESSSAVYQCN ECCCCCCCCCEEEEC	22.89	17242355
421	Phosphorylation	SNVQESSSAVYQCNA CCCCCCCCCEEEECC	30.91	17242355
427	N-linked_Glycosylation	SSAVYQCNASNKYGY CCCEEEECCCCCHHE	30.77	-
501	N-linked_Glycosylation	DIYVLHDNGTLEIPV CEEEEECCCEEEEEC	34.30	-
613	N-linked_Glycosylation	GTYTCTANTTLDSAS CEEEEECCCEECCCC	18.55	-
706	Phosphorylation	TTAQLKLSPYVNYSF EEEEEEECCCCCCEE	16.76	28059163
710	N-linked_Glycosylation	LKLSPYVNYSFRVMA EEECCCCCCEEEEEE	22.38	-
720	Phosphorylation	FRVMAENSIGRSMPS EEEEEECCCCCCCCC	20.23	28059163
796	N-linked_Glycosylation	WTSVVVANVSKYIVS CEEEEEEEEEEEEEC	27.30	-
811	Phosphorylation	GTPTFVPYLIKVQAL CCCCCHHEEEEEEEC	18.76	28576409
852	N-linked_Glycosylation	NVRVSVVNSTLAEVH CEEEEEECCCCEEEE	27.41	-
987	N-linked_Glycosylation	ILQYQPINSTHELGP HHHHCCCCCCCCCCC	47.76	-
1003	N-linked_Glycosylation	VDLKIPANKTRWTLK EEEECCCCCCEEEEE	40.66	-
1013	N-linked_Glycosylation	RWTLKNLNFSTRYKF EEEEECCCCCCCEEE	37.91	-
1067	N-linked_Glycosylation	EWRKEIVNGSRSFFG HHHHHHHCCCCCCCC	48.67	-
1168	Ubiquitination	DPEIQPMKEDDGTFG CCCCCCCCCCCCCCC	65.75	22790023
1168 (in isoform 3)	Ubiquitination	-	65.75	22790023
1173	Phosphorylation	PMKEDDGTFGEYSDA CCCCCCCCCCCCCCC	35.15	24925903
1177	Phosphorylation	DDGTFGEYSDAEDHK CCCCCCCCCCCCCCC	16.54	24925903
1178	Phosphorylation	DGTFGEYSDAEDHKP CCCCCCCCCCCCCCC	26.49	25521595
1179 (in isoform 3)	Phosphorylation	-	53.74	20415495
1182 (in isoform 3)	Phosphorylation	-	57.75	20415495
1190	Phosphorylation	HKPLKKGSRTPSDRT CCCCCCCCCCCCCCC	41.69	29899451
1192	Phosphorylation	PLKKGSRTPSDRTVK CCCCCCCCCCCCCCC	28.92	29899451
1194	Phosphorylation	KKGSRTPSDRTVKKE CCCCCCCCCCCCCHH	38.83	29899451
1197	Phosphorylation	SRTPSDRTVKKEDSD CCCCCCCCCCHHHCC	41.49	22324799
1203	Phosphorylation	RTVKKEDSDDSLVDY CCCCHHHCCCCCCCC	44.39	19060867
1206	Phosphorylation	KKEDSDDSLVDYGEG CHHHCCCCCCCCCCC	34.97	19060867
1210	Phosphorylation	SDDSLVDYGEGVNGQ CCCCCCCCCCCCCCC	15.03	29899451
1223	Phosphorylation	GQFNEDGSFIGQYSG CCCCCCCCCCCCCCC	26.47	19060867
1228	Phosphorylation	DGSFIGQYSGKKEKE CCCCCCCCCCCCCCC	17.74	-
1242	Phosphorylation	EPAEGNESSEAPSPV CCCCCCCCCCCCCCC	37.16	25521595
1243	Phosphorylation	PAEGNESSEAPSPVN CCCCCCCCCCCCCCC	31.44	25521595
1247	Phosphorylation	NESSEAPSPVNAMNS CCCCCCCCCCCCCCC	48.83	25521595
1254	Phosphorylation	SPVNAMNSFV----- CCCCCCCCCC-----	17.82	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NRCAM_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NRCAM_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NRCAM_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
DLG4_MOUSE	Dlg4	physical	16882004
DLG1_MOUSE	Dlg1	physical	16882004

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NRCAM_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1178, AND MASSSPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-421, AND MASSSPECTROMETRY.	17242355 [Abstract]
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1247, AND MASSSPECTROMETRY.	17114649 [Abstract]