dbPTM

E41L2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	E41L2_MOUSE
UniProt AC	O70318
Protein Name	Band 4.1-like protein 2
Gene Name	Epb41l2
Organism	Mus musculus (Mouse).
Sequence Length	988
Subcellular Localization	Cytoplasm, cytoskeleton. Cytoplasm, cell cortex . Cell membrane .
Protein Description	Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase..
Protein Sequence	MTTEVGSASEVKKGSDQAGADASKEKAKEVENEQTPVSEPEEEKGSQPGPPVERQSTPRLRKRGKDPSENRGISRFIPPWLKKQRSYNLVVAKDGGDKKEPTQADVEDQILGKEESLPEEESRAKGDAEEMAQRKHLEVQVEVREAKPALKSSVETQPAEEVRKDKEETIQDTQEEKLEGGAAKRETKEVQTSELKAEVASQKATKKTKTVLAKVTLLDGTEYSCDLEKRAKGQVLFDRVCEHLNLLEKDYFGLLFQDHPEQKNWLDPAKEIKRQLKNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAEHGDYDPEEYDSIDLGDFQFAPAHTKELEEKVSELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKTKFLTLGSKFRYSGRTQAQTREASTLIDRPAPQFERASSKRVSRSLDGAPIGVVDQSPPGEGSVPGPGVISYTTIQDGRRDSKSPTKATPLPAEGKKNTLRVDGDNIYVRHSNLMLEDLDKAQEAILKHQASISELKRNFMASTPEPRPSEWEKRRVTPLPFQPQASSHETLNVVEEKKRAEVGKDESVITEEMNGKEMSPGHGPGETRKVEPVAHKDSTSLSSESSSSSSESEEDVGEYQPHHRVTEGTIREEQEECDEELEEEPGQGAKVVEREAAVPDAVPDRQAGASVLPVETEAQEHVVAQKLPGEKGAHGGTAEQDPREEAEEDPHRVNGEVPHLDLDGLPEIICCSEPPVVKTEMVTISDASQRTEISTKEVPIVQTETKTITYESPQIDGGAGGDSGVLLTAQTITSESASTTTTTHITKTVKGGISETRIEKRIVITGDAALDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEEGEE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MTTEVGSAS ------CCCCCCCHH	31.50	-
2	Phosphorylation	------MTTEVGSAS ------CCCCCCCHH	31.50	29176673
3	Phosphorylation	-----MTTEVGSASE -----CCCCCCCHHH	27.63	29176673
7	Phosphorylation	-MTTEVGSASEVKKG -CCCCCCCHHHCCCC	33.52	26824392
9	Phosphorylation	TTEVGSASEVKKGSD CCCCCCHHHCCCCCC	44.62	21743459
15	Phosphorylation	ASEVKKGSDQAGADA HHHCCCCCCCCCCCC	35.11	27149854
35	Phosphorylation	KEVENEQTPVSEPEE HHHHCCCCCCCCCHH	21.34	23684622
38	Phosphorylation	ENEQTPVSEPEEEKG HCCCCCCCCCHHHCC	48.95	27087446
46	Phosphorylation	EPEEEKGSQPGPPVE CCHHHCCCCCCCCCC	44.24	25619855
56	Phosphorylation	GPPVERQSTPRLRKR CCCCCCCCCHHHHHC	46.75	24719451
57	Phosphorylation	PPVERQSTPRLRKRG CCCCCCCCHHHHHCC	12.23	22817900
68	Phosphorylation	RKRGKDPSENRGISR HHCCCCCCCCCCCCC	58.60	27149854
86	Phosphorylation	PWLKKQRSYNLVVAK HHHHHCCCCCEEEEE	18.84	27087446
87	Phosphorylation	WLKKQRSYNLVVAKD HHHHCCCCCEEEEEC	18.07	27742792
102	Phosphorylation	GGDKKEPTQADVEDQ CCCCCCCCCCCHHHH	37.16	25159016
116	Phosphorylation	QILGKEESLPEEESR HHCCCHHCCCHHHHH	50.76	25521595
122	Phosphorylation	ESLPEEESRAKGDAE HCCCHHHHHHHCCHH	40.60	27742792
152	Phosphorylation	EAKPALKSSVETQPA HHHHHHHHCCCCCCH	40.23	23375375
153	Phosphorylation	AKPALKSSVETQPAE HHHHHHHCCCCCCHH	23.53	19367708
156	Phosphorylation	ALKSSVETQPAEEVR HHHHCCCCCCHHHHH	37.38	-
169	Phosphorylation	VRKDKEETIQDTQEE HHCCHHHHCCHHHHH	25.65	23684622
173	Phosphorylation	KEETIQDTQEEKLEG HHHHCCHHHHHHHCC	22.85	23684622
187	Phosphorylation	GGAAKRETKEVQTSE CCCCCCCCCCCHHHH	36.22	27681418
192	Phosphorylation	RETKEVQTSELKAEV CCCCCCHHHHHHHHH	29.37	21743459
193	Phosphorylation	ETKEVQTSELKAEVA CCCCCHHHHHHHHHH	24.68	25521595
196	Ubiquitination	EVQTSELKAEVASQK CCHHHHHHHHHHHHH	38.15	-
201	Phosphorylation	ELKAEVASQKATKKT HHHHHHHHHHCCHHH	37.07	26824392
205	Phosphorylation	EVASQKATKKTKTVL HHHHHHCCHHHHEEE	39.86	26160508
229	Acetylation	EYSCDLEKRAKGQVL EEECCHHHHHCCCHH	66.02	22826441
229	Ubiquitination	EYSCDLEKRAKGQVL EEECCHHHHHCCCHH	66.02	-
263	Ubiquitination	FQDHPEQKNWLDPAK CCCCHHHCCCCCHHH	48.72	-
348	Phosphorylation	YDPEEYDSIDLGDFQ CCHHHCCCCCCCCCC	19.66	25338131
367	Ubiquitination	HTKELEEKVSELHKT CHHHHHHHHHHHHHH	41.51	-
369	Phosphorylation	KELEEKVSELHKTHR HHHHHHHHHHHHHHC	45.57	27149854
373	Ubiquitination	EKVSELHKTHRGLSP HHHHHHHHHHCCCCH	59.66	-
379	Phosphorylation	HKTHRGLSPAQADSQ HHHHCCCCHHHHHHH	22.48	25521595
385	Phosphorylation	LSPAQADSQFLENAK CCHHHHHHHHHHHHH	26.33	29899451
392	Ubiquitination	SQFLENAKRLSMYGV HHHHHHHHHHHHHCC	66.51	-
395	Phosphorylation	LENAKRLSMYGVDLH HHHHHHHHHHCCCCH	17.62	25521595
397	Phosphorylation	NAKRLSMYGVDLHHA HHHHHHHHCCCCHHC	15.60	25521595
405	Ubiquitination	GVDLHHAKDSEGVDI CCCCHHCCCCCCCCC	58.38	-
449	Phosphorylation	SYKRSNFYIKVRPAE EEECCCEEEEECHHH	12.23	18779572
486	Phosphorylation	KVCVEHHTFYRLVSP HHHHHHCCEEEECCC	25.03	23140645
488	Phosphorylation	CVEHHTFYRLVSPEQ HHHHCCEEEECCCCC	12.28	23140645
492	Phosphorylation	HTFYRLVSPEQPPKT CCEEEECCCCCCCCC	27.58	26824392
503	Phosphorylation	PPKTKFLTLGSKFRY CCCCCEEECCCCCCC	32.00	25521595
506	Phosphorylation	TKFLTLGSKFRYSGR CCEEECCCCCCCCCC	31.56	22324799
507	Acetylation	KFLTLGSKFRYSGRT CEEECCCCCCCCCCC	31.87	23806337
507	Ubiquitination	KFLTLGSKFRYSGRT CEEECCCCCCCCCCC	31.87	-
510	Phosphorylation	TLGSKFRYSGRTQAQ ECCCCCCCCCCCCCC	20.71	21454597
511	Phosphorylation	LGSKFRYSGRTQAQT CCCCCCCCCCCCCCH	19.97	18388127
514	Phosphorylation	KFRYSGRTQAQTREA CCCCCCCCCCCHHHH	31.61	29514104
518	Phosphorylation	SGRTQAQTREASTLI CCCCCCCHHHHHHHC	33.23	29514104
522	Phosphorylation	QAQTREASTLIDRPA CCCHHHHHHHCCCCC	20.99	29514104
523	Phosphorylation	AQTREASTLIDRPAP CCHHHHHHHCCCCCH	34.48	29514104
536	Phosphorylation	APQFERASSKRVSRS CHHHHHHHCCCCHHC	42.48	27600695
537	Phosphorylation	PQFERASSKRVSRSL HHHHHHHCCCCHHCC	24.40	26824392
541	Phosphorylation	RASSKRVSRSLDGAP HHHCCCCHHCCCCCC	21.86	26643407
543	Phosphorylation	SSKRVSRSLDGAPIG HCCCCHHCCCCCCEE	24.25	25521595
555	Phosphorylation	PIGVVDQSPPGEGSV CEEEECCCCCCCCCC	28.71	24925903
561	Phosphorylation	QSPPGEGSVPGPGVI CCCCCCCCCCCCCEE	22.34	24925903
569	Phosphorylation	VPGPGVISYTTIQDG CCCCCEEEEEEEECC	17.64	24925903
570	Phosphorylation	PGPGVISYTTIQDGR CCCCEEEEEEEECCC	9.22	26643407
571	Phosphorylation	GPGVISYTTIQDGRR CCCEEEEEEEECCCC	15.61	26643407
572	Phosphorylation	PGVISYTTIQDGRRD CCEEEEEEEECCCCC	14.38	24453211
580	Phosphorylation	IQDGRRDSKSPTKAT EECCCCCCCCCCCCC	32.97	23684622
582	Phosphorylation	DGRRDSKSPTKATPL CCCCCCCCCCCCCCC	41.58	22942356
584	Phosphorylation	RRDSKSPTKATPLPA CCCCCCCCCCCCCCC	40.16	26160508
587	Phosphorylation	SKSPTKATPLPAEGK CCCCCCCCCCCCCCC	27.24	24899341
597	Phosphorylation	PAEGKKNTLRVDGDN CCCCCCCEEEECCCE	25.48	26824392
606	Phosphorylation	RVDGDNIYVRHSNLM EECCCEEEEECCCEE	9.55	23684622
610	Phosphorylation	DNIYVRHSNLMLEDL CEEEEECCCEEHHCH	22.54	25521595
630	Phosphorylation	AILKHQASISELKRN HHHHHHCCHHHHHHH	21.78	25521595
632	Phosphorylation	LKHQASISELKRNFM HHHHCCHHHHHHHHH	34.09	28725479
641	Phosphorylation	LKRNFMASTPEPRPS HHHHHHHCCCCCCCC	32.48	24719451
642	Phosphorylation	KRNFMASTPEPRPSE HHHHHHCCCCCCCCH	23.33	26643407
656	Phosphorylation	EWEKRRVTPLPFQPQ HHHHCCCCCCCCCCC	19.80	26824392
665	Phosphorylation	LPFQPQASSHETLNV CCCCCCCCCCCCCHH	27.29	20469934
666	Phosphorylation	PFQPQASSHETLNVV CCCCCCCCCCCCHHH	28.49	27087446
669	Phosphorylation	PQASSHETLNVVEEK CCCCCCCCCHHHHHH	20.43	25168779
689	Phosphorylation	GKDESVITEEMNGKE CCCCCCEEEECCCCC	24.60	22942356
698	Phosphorylation	EMNGKEMSPGHGPGE ECCCCCCCCCCCCCC	28.90	25521595
706	Phosphorylation	PGHGPGETRKVEPVA CCCCCCCCCEEECCC	41.53	25159016
717	Phosphorylation	EPVAHKDSTSLSSES ECCCCCCCCCCCCCC	25.38	25338131
718	Phosphorylation	PVAHKDSTSLSSESS CCCCCCCCCCCCCCC	43.77	25338131
719	Phosphorylation	VAHKDSTSLSSESSS CCCCCCCCCCCCCCC	30.15	26525534
721	Phosphorylation	HKDSTSLSSESSSSS CCCCCCCCCCCCCCC	31.65	23984901
722	Phosphorylation	KDSTSLSSESSSSSS CCCCCCCCCCCCCCC	46.95	23984901
724	Phosphorylation	STSLSSESSSSSSES CCCCCCCCCCCCCCC	37.15	23984901
725	Phosphorylation	TSLSSESSSSSSESE CCCCCCCCCCCCCCH	30.13	23984901
726	Phosphorylation	SLSSESSSSSSESEE CCCCCCCCCCCCCHH	43.44	23984901
727	Phosphorylation	LSSESSSSSSESEED CCCCCCCCCCCCHHH	39.57	23984901
728	Phosphorylation	SSESSSSSSESEEDV CCCCCCCCCCCHHHC	39.82	23984901
729	Phosphorylation	SESSSSSSESEEDVG CCCCCCCCCCHHHCC	47.27	23984901
731	Phosphorylation	SSSSSSESEEDVGEY CCCCCCCCHHHCCCC	48.51	23984901
738	Phosphorylation	SEEDVGEYQPHHRVT CHHHCCCCCCCCCCC	22.78	-
745	Phosphorylation	YQPHHRVTEGTIREE CCCCCCCCCCCCHHH	28.75	25619855
748	Phosphorylation	HHRVTEGTIREEQEE CCCCCCCCCHHHHHH	15.61	25619855
849	Glutathionylation	DGLPEIICCSEPPVV CCCCEEEEECCCCEE	2.28	24333276
864	Phosphorylation	KTEMVTISDASQRTE EEEEEECCCHHHCCC	20.12	29514104
889	Phosphorylation	TETKTITYESPQIDG EEEEEEEEECCCCCC	15.57	22817900
933	Phosphorylation	KTVKGGISETRIEKR EECCCCCCCCEEEEE	35.87	22324799
935	Phosphorylation	VKGGISETRIEKRIV CCCCCCCCEEEEEEE	30.10	29550500
970	Phosphorylation	REQHPDMSVTRVVVH HHHCCCCCEEEEEEE	27.93	30387612

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of E41L2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of E41L2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of E41L2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of E41L2_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of E41L2_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-38 AND TYR-606, AND MASSSPECTROMETRY.	19131326 [Abstract]
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-38; SER-582 AND SER-698,AND MASS SPECTROMETRY.	19144319 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86; SER-610 AND SER-630,AND MASS SPECTROMETRY.	19367708 [Abstract]
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-38, AND MASSSPECTROMETRY.	16452087 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-745, AND MASSSPECTROMETRY.	17242355 [Abstract]