PHAR1_MOUSE - dbPTM
PHAR1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PHAR1_MOUSE
UniProt AC Q2M3X8
Protein Name Phosphatase and actin regulator 1
Gene Name Phactr1
Organism Mus musculus (Mouse).
Sequence Length 580
Subcellular Localization Cytoplasm. Cell junction, synapse. Nucleus. Enriched at synapses (By similarity). Cytoplasmic in resting cells, and is imported into the nucleus upon serum stimulation. Interaction with actin prevents nuclear import..
Protein Description Binds actin monomers (G actin) and plays a role in the reorganization of the actin cytoskeleton and in formation of actin stress fibers. Plays a role in the formation of tubules by endothelial cells. Regulates PPP1CA activity. Required for normal cell survival (By similarity). Plays a role in cell motility..
Protein Sequence MDYPKMDYFLDVESAHRLLDVESAQRFFYSQGAQARRATLLLPPTLMAASSEDDIDRRPIRRVRSKSDTPYLAEARISFNLGAAEEVERLAAMRSDSLVPGTHTPPIRRRSKFANLGRIFKPWKWRKKKSEKFKHTSAALERKISMRQSREELIKRGVLKEIYDKDGELSISNEDDSLENGQSLSSSQLSLPALSEMEPVPMPRDPCSYEVLQASDIMDGPDPGAPVKLPCLPVKLSPPLPPKKVLICMPVGGPELTLASYAAQKSSQQAVAQHHHTVLPSQMQHQLQYGSHGQHLPSSTGTLPMHPSGCRMIDELNKTLAMTMQRLESSEQRVPCSTSYHSSGLHSSDGITKAGPMGLPEIRQVPTVVIECDDNKENVPHEPDYEDSPCLYGREEEEEEEDEDDDASLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQEEKREIKRRLTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRADKPWTRLTAADKAAIRKELNEFKSTEMEVHELSRHLTRFHRP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
39PhosphorylationGAQARRATLLLPPTL
HHHHHHHHEECCCCH		19.0019060867
45PhosphorylationATLLLPPTLMAASSE
HHEECCCCHHCCCCC		27.5020415495
65PhosphorylationRPIRRVRSKSDTPYL
CCCHHCCCCCCCCCE		33.3819060867
67PhosphorylationIRRVRSKSDTPYLAE
CHHCCCCCCCCCEEE		48.2225521595
69PhosphorylationRVRSKSDTPYLAEAR
HCCCCCCCCCEEEEH		22.4119060867
71PhosphorylationRSKSDTPYLAEARIS
CCCCCCCCEEEEHHE		22.1923335269
78PhosphorylationYLAEARISFNLGAAE
CEEEEHHEECCCCHH		11.5219060867
95PhosphorylationERLAAMRSDSLVPGT
HHHHHHCCCCCCCCC		20.6129899451
97PhosphorylationLAAMRSDSLVPGTHT
HHHHCCCCCCCCCCC		32.2929899451
102PhosphorylationSDSLVPGTHTPPIRR
CCCCCCCCCCCCCCC		19.2619060867
104PhosphorylationSLVPGTHTPPIRRRS
CCCCCCCCCCCCCCH		30.5121082442
145PhosphorylationAALERKISMRQSREE
HHHHHHHHHHHCHHH		15.7923608596
149PhosphorylationRKISMRQSREELIKR
HHHHHHHCHHHHHHC		31.1522324799
170PhosphorylationYDKDGELSISNEDDS
HCCCCCEECCCCCCC		21.4821183079
190PhosphorylationSLSSSQLSLPALSEM
CCCHHHCCCCCHHCC		25.3529899451
215PhosphorylationSYEVLQASDIMDGPD
CCEEEHHHHCCCCCC		18.0829899451
237PhosphorylationPCLPVKLSPPLPPKK
CEEECCCCCCCCCCE		20.8227180971
299PhosphorylationHGQHLPSSTGTLPMH
CCCCCCCCCCCCCCC		28.9922807455
329PhosphorylationMTMQRLESSEQRVPC
HHHHHHHCCCCCCCC		43.71-
337O-linked_GlycosylationSEQRVPCSTSYHSSG
CCCCCCCCCCCCCCC		17.8322645316
385PhosphorylationNVPHEPDYEDSPCLY
CCCCCCCCCCCCCCC		32.1421183079
423PhosphorylationMKVCRKDSLAIKLSN
HHHHCCCCHHHHCCC		23.8021183079
467PhosphorylationTKLTRRLSQRPTAEE
HHHHHHHHCCCCHHH		23.4927742792
471PhosphorylationRRLSQRPTAEELEQR
HHHHCCCCHHHHHHC		49.2225266776
501PhosphorylationREIKRRLTRKLSQRP
HHHHHHHHHHHHCCC		24.77-
505PhosphorylationRRLTRKLSQRPTVEE
HHHHHHHHCCCCHHH		27.4627841257
509PhosphorylationRKLSQRPTVEELRER
HHHHCCCCHHHHHHC		42.6229899451
525PhosphorylationILIRFSDYVEVADAQ
EEEECHHCEEECCHH		9.4129514104
562PhosphorylationKELNEFKSTEMEVHE
HHHHHHHCCHHHHHH		34.6129899451
563PhosphorylationELNEFKSTEMEVHEL
HHHHHHCCHHHHHHH		39.6829899451
576DimethylationELSRHLTRFHRP---
HHHHHHHHHCCC---		31.56-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PHAR1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PHAR1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PHAR1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PHAR1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PHAR1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations.";
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.;
Mol. Cell. Proteomics 5:914-922(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-104, AND MASSSPECTROMETRY.

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