dbPTM

ALEX_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ALEX_MOUSE
UniProt AC	Q6R0H6
Protein Name	Protein ALEX
Gene Name	Gnas {ECO:0000312\|MGI:MGI:95777}
Organism	Mus musculus (Mouse).
Sequence Length	725
Subcellular Localization	Cell membrane Peripheral membrane protein. Cell projection, ruffle. Predominantly associated with cell membrane ruffles..
Protein Description	May inhibit the adenylyl cyclase-stimulating activity of guanine nucleotide-binding protein G(s) subunit alpha which is produced from the same locus in a different open reading frame..
Protein Sequence	MSPSPTRLAVRSVDPQKTPNLTSKAPARPSRKSEWVETTAHLRRKPCHSRHNSPAWEISGPPWSSQDHLGPHQASKPSTQRFWSPGPPLARAQAWEPIPPHQKKLCHLSSTSLPRETIASLPCKSQTLRQEVRKHWSPELFPRSPGTSDLKTLASEKTTALPLKNLCHFRSVEKNSGAIAHPQDSRESSHKSALAASSRQSRSRVRSASLPPRTRLPSGSEAPLTDHSARLSDLLLTSHATAPRWRSPDPCLRLAEPPLGSTTTPLSIWTAPQSQVMARPSKSREPQIRASAQRDPQLSEKQPRWKEALPPPLRWKEKSPLRREGTDLPPSLKQWMPSQPLLPKPSLPDLMLELLRIPRCSQIARAMPEKTGQPQERLQISSRILKNSKKPQLSAPILTEGQPQSPQPLLPSPSLKAAEIQPPSQPPRQSLPPRPSLPPGQPLSPRWSPQPRQSLPPWRSLPPGQPLSPPRSPLPGQSPLLEPIRPLEQSLAPQQCQPLLGQLPLGQPMQVHWSGEPGHSQLLPPLGHPFLPAQQLPPGQPLLPAQSLLAGQPLPPPAGPILDPPAPRSRLLTRLLRGLLRGRLPGLTSTSGAEAAAGTRHRLASARSSPPVMSRKKGPPAASSGFCGETAALACPGATRSGATQSATSSPEPSEAASVYPSVPDHDPSAPGRPRILWRRGANRCAKKPLRCESRSAQIRNAASSSTSNWRRRRWTTCVHTACCF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	PTRLAVRSVDPQKTP CCEEEEECCCCCCCC	25.03	21454597
23	Phosphorylation	QKTPNLTSKAPARPS CCCCCCCCCCCCCCC	29.95	21454597
609	Phosphorylation	RLASARSSPPVMSRK HHHHHHCCCCCHHCC	27.89	22982522
614	Phosphorylation	RSSPPVMSRKKGPPA HCCCCCHHCCCCCCC	40.98	22982522

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ALEX_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ALEX_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ALEX_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ALEX_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ALEX_MOUSE

Related Literatures of Post-Translational Modification