dbPTM

LRRC7_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LRRC7_MOUSE
UniProt AC	Q80TE7
Protein Name	Leucine-rich repeat-containing protein 7
Gene Name	Lrrc7
Organism	Mus musculus (Mouse).
Sequence Length	1490
Subcellular Localization	Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density .
Protein Description	Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression..
Protein Sequence	MTTKRKLIGRLVPCRCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSSLPTSIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFSELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPPTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQRLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQRVLTNYMFPQQPRGDEDFQSDSDSFNPTLWEEQRQQRMTVAFEFEDKKEDDESAGKVKALSCQAPWDRGQRGITLQPARLSGDCCTPWARCDQQIQDMPVPQSDPQLAWGCISGLQQERSMCAPLPVAAQSTTLPSLSGRQVEINLKRYPTPYPEDLKNMVKSVQNLVGKPSHGVRVENSNPTANTEQTVKEKFEHKWPVAPKEITVEDSFVHPANEMRIGELHPSLAETPLYPPKLVLLGKDKKESTDESEVDKTHCLNNSVSSGTYSDYSPSQASSASSNTRMKVGSLQATAKDAVHNSLWGNRIAPPFPQPLDAKPLLSQREAVPPGNIPQRPDRLPMSDAFPDNWTDGSHYDNTGFVSEEAAGENANNNPLLSSKARSVPAHGRRPLIRQERIVGVPLELEQSTHRHTPETEVPPSNPWQNWTRTPSPFEDRTAFPSKLETTPTTSPLPERKDHMKEPTETPGPFSPGVPWEYHDPTPNRSLGNVFSQIHCRPDSSKGVIAISKSTERLSPLMKDIKSNKFKKSQSIDEIDVGTYKVYNIPLENYASGSDHLGSHERPDKFLGPEHGMSSMSRSQSVPMLDDEMLMYGSSKGPPQQKASMTKKVYQFDQSFNPQGAVEVKAEKRIPPPFAHNSEYVQQPSKNIAKDLVSPRAYRGYPPMEQMFSFSQPSVNEDAMVNAQFASQGPRAGFLRRADSLASSTEMAMFRRVSEPHELPPGDRYGRATYRGGLEGQSSISMTDPQFLKRNGRYEDEHPSYQEVKAQAGSFPAKNLTQRRPLSARSYSTESYGASQTRPVSARPTMAALLEKIPSDYNLGNYGDKTSDNSDIKTRPTPVKGEESCGKMPADWRQQLLRHIEARRLDRTPSQQSNILDNGQEDVSPSGQWNPYPLGRRDVPPDTITKKAGSHIQTLMGSQSLQHRSREQQPYEGNINKVTIQQFQSPLPIQIPSSQATRGPQPGRCLIQTKGQRSMDGYPEQFCVRIEKNPGLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPASNLLQPGDKILQANGHSFVHMEHEKAVLLLKSFQNTVDLVIQRELTV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	S-palmitoylation	SVLDYSHCSLQQVPK EEEECCCCCHHHCCH	3.41	28680068
47	Phosphorylation	EVFNFERTLEELYLD HHHCHHHHHHHHHCC	31.18	20415495
52	Phosphorylation	ERTLEELYLDANQIE HHHHHHHHCCHHHHH	13.05	20415495
68	S-palmitoylation	LPKQLFNCQALRKLS HHHHHHCCHHHHHCC	1.64	28680068
75	Phosphorylation	CQALRKLSIPDNDLS CHHHHHCCCCCCCHH	34.80	29899451
82	Phosphorylation	SIPDNDLSSLPTSIA CCCCCCHHHCCHHHH	32.46	22807455
83	Phosphorylation	IPDNDLSSLPTSIAS CCCCCHHHCCHHHHH	45.74	29899451
381	Ubiquitination	NLSDNRLKNLPFSFT ECCCCCHHCCCCCHH	53.88	-
389	Ubiquitination	NLPFSFTKLKELAAL CCCCCHHHHHHHHHH	56.40	-
403	Phosphorylation	LWLSDNQSKALIPLQ HHCCCCCCCCEEECC	26.59	29899451
404	Ubiquitination	WLSDNQSKALIPLQT HCCCCCCCCEEECCC	37.13	-
418	Ubiquitination	TEAHPETKQRVLTNY CCCCHHHHHHHHHHH	34.15	-
439	Phosphorylation	RGDEDFQSDSDSFNP CCCCCCCCCCCCCCH	38.79	25521595
441	Phosphorylation	DEDFQSDSDSFNPTL CCCCCCCCCCCCHHH	40.16	21183079
443	Phosphorylation	DFQSDSDSFNPTLWE CCCCCCCCCCHHHHH	30.76	25521595
472	Phosphorylation	DKKEDDESAGKVKAL CCCCCCCCCCCEEEE	49.68	30387612
500	Phosphorylation	TLQPARLSGDCCTPW EECCCCCCCCCCCCC	27.34	22324799
505	Phosphorylation	RLSGDCCTPWARCDQ CCCCCCCCCCHHCCH	28.35	22324799
568	Phosphorylation	VEINLKRYPTPYPED EEEEEEECCCCCHHH	15.18	23984901
570	Phosphorylation	INLKRYPTPYPEDLK EEEEECCCCCHHHHH	26.90	23608596
572	Phosphorylation	LKRYPTPYPEDLKNM EEECCCCCHHHHHHH	23.02	23984901
666	Phosphorylation	LGKDKKESTDESEVD ECCCCCCCCCHHHCC	50.46	22324799
667	Phosphorylation	GKDKKESTDESEVDK CCCCCCCCCHHHCCH	44.89	22324799
670	Phosphorylation	KKESTDESEVDKTHC CCCCCCHHHCCHHHH	45.81	22324799
690	Phosphorylation	SSGTYSDYSPSQASS CCCCCCCCCHHHCCC	19.28	-
708	Phosphorylation	NTRMKVGSLQATAKD CCCCCCCCEEHHHHH	21.94	22324799
712	Phosphorylation	KVGSLQATAKDAVHN CCCCEEHHHHHHHHH	22.68	22324799
737	Ubiquitination	FPQPLDAKPLLSQRE CCCCCCCCCCCCCCC	35.55	-
801	Phosphorylation	LLSSKARSVPAHGRR CCCHHCCCCCCCCCC	36.99	29899451
826	Phosphorylation	VPLELEQSTHRHTPE CCCEEECCCCCCCCC	19.46	22324799
827	Phosphorylation	PLELEQSTHRHTPET CCEEECCCCCCCCCC	23.71	19060867
831	Phosphorylation	EQSTHRHTPETEVPP ECCCCCCCCCCCCCC	23.83	19060867
834	Phosphorylation	THRHTPETEVPPSNP CCCCCCCCCCCCCCC	43.41	21183079
848	Phosphorylation	PWQNWTRTPSPFEDR CCCCCCCCCCCCCCC	22.27	22324799
850	Phosphorylation	QNWTRTPSPFEDRTA CCCCCCCCCCCCCCC	41.42	22324799
856	Phosphorylation	PSPFEDRTAFPSKLE CCCCCCCCCCCCCCC	45.00	29899451
860	Phosphorylation	EDRTAFPSKLETTPT CCCCCCCCCCCCCCC	43.34	29899451
864	Phosphorylation	AFPSKLETTPTTSPL CCCCCCCCCCCCCCC	48.81	25521595
865	Phosphorylation	FPSKLETTPTTSPLP CCCCCCCCCCCCCCC	14.84	25521595
867	Phosphorylation	SKLETTPTTSPLPER CCCCCCCCCCCCCCC	37.50	25521595
868	Phosphorylation	KLETTPTTSPLPERK CCCCCCCCCCCCCCC	29.56	25521595
869	Phosphorylation	LETTPTTSPLPERKD CCCCCCCCCCCCCCC	27.24	22324799
904	O-linked_Glycosylation	HDPTPNRSLGNVFSQ CCCCCCCCCCCCCCE	47.47	55412519
918	Phosphorylation	QIHCRPDSSKGVIAI EEECCCCCCCCEEEE	36.31	29899451
919	Phosphorylation	IHCRPDSSKGVIAIS EECCCCCCCCEEEEE	40.59	29899451
926	Phosphorylation	SKGVIAISKSTERLS CCCEEEEECCCCCCC	16.13	23737553
928	Phosphorylation	GVIAISKSTERLSPL CEEEEECCCCCCCHH	28.80	22324799
929	Phosphorylation	VIAISKSTERLSPLM EEEEECCCCCCCHHH	28.94	22324799
933	Phosphorylation	SKSTERLSPLMKDIK ECCCCCCCHHHHHHH	23.39	22324799
947	Phosphorylation	KSNKFKKSQSIDEID HCCCCCCCCCCCEEC	29.74	25521595
949	Phosphorylation	NKFKKSQSIDEIDVG CCCCCCCCCCEECCC	38.81	25521595
970	Phosphorylation	IPLENYASGSDHLGS EECCCCCCCCCCCCC	28.59	29899451
972	Phosphorylation	LENYASGSDHLGSHE CCCCCCCCCCCCCCC	21.25	29899451
977	Phosphorylation	SGSDHLGSHERPDKF CCCCCCCCCCCCCCC	28.65	29899451
992	Phosphorylation	LGPEHGMSSMSRSQS CCCCCCCCCCCCCCC	27.73	29899451
993	Phosphorylation	GPEHGMSSMSRSQSV CCCCCCCCCCCCCCC	16.34	29899451
995	O-linked_Glycosylation	EHGMSSMSRSQSVPM CCCCCCCCCCCCCCC	30.63	55412511
997	Phosphorylation	GMSSMSRSQSVPMLD CCCCCCCCCCCCCCC	21.35	29899451
999	Phosphorylation	SSMSRSQSVPMLDDE CCCCCCCCCCCCCHH	29.45	29899451
1028	Phosphorylation	ASMTKKVYQFDQSFN HHHCCEEEEECCCCC	16.61	29899451
1072	Phosphorylation	NIAKDLVSPRAYRGY CHHHHHCCCCHHCCC	18.90	22324799
1118	Phosphorylation	GFLRRADSLASSTEM CHHHHHHHHCCCHHH	25.50	25521595
1121	Phosphorylation	RRADSLASSTEMAMF HHHHHHCCCHHHHHH	42.98	25521595
1122	Phosphorylation	RADSLASSTEMAMFR HHHHHCCCHHHHHHH	23.84	29899451
1123	Phosphorylation	ADSLASSTEMAMFRR HHHHCCCHHHHHHHC	27.56	25521595
1132	Phosphorylation	MAMFRRVSEPHELPP HHHHHCCCCCCCCCC	43.53	18056256
1147	Phosphorylation	GDRYGRATYRGGLEG CCCCCCCEECCCCCC	16.64	29899451
1148	Phosphorylation	DRYGRATYRGGLEGQ CCCCCCEECCCCCCC	13.28	29899451
1149	Methylation	RYGRATYRGGLEGQS CCCCCEECCCCCCCC	28.48	24129315
1156	Phosphorylation	RGGLEGQSSISMTDP CCCCCCCCCCCCCCH	40.26	29899451
1157	Phosphorylation	GGLEGQSSISMTDPQ CCCCCCCCCCCCCHH	15.70	25521595
1159	Phosphorylation	LEGQSSISMTDPQFL CCCCCCCCCCCHHHH	19.99	25521595
1161	Phosphorylation	GQSSISMTDPQFLKR CCCCCCCCCHHHHHH	37.42	25521595
1188	Phosphorylation	EVKAQAGSFPAKNLT HHHHHCCCCCCCCCC	30.95	29899451
1204	Phosphorylation	RRPLSARSYSTESYG CCCCCCCCCCCCCCC	24.13	20415495
1205	Phosphorylation	RPLSARSYSTESYGA CCCCCCCCCCCCCCC	17.66	20415495
1206	Phosphorylation	PLSARSYSTESYGAS CCCCCCCCCCCCCCC	27.26	19060867
1207	Phosphorylation	LSARSYSTESYGASQ CCCCCCCCCCCCCCC	22.25	29899451
1209	Phosphorylation	ARSYSTESYGASQTR CCCCCCCCCCCCCCC	29.02	20415495
1219	Phosphorylation	ASQTRPVSARPTMAA CCCCCCCCCCHHHHH	22.65	29899451
1233	Phosphorylation	ALLEKIPSDYNLGNY HHHHHCCCCCCCCCC	57.08	19060867
1235	Phosphorylation	LEKIPSDYNLGNYGD HHHCCCCCCCCCCCC	19.34	29899451
1240	Phosphorylation	SDYNLGNYGDKTSDN CCCCCCCCCCCCCCC	25.54	29899451
1245	Phosphorylation	GNYGDKTSDNSDIKT CCCCCCCCCCCCCCC	40.30	29899451
1248	Phosphorylation	GDKTSDNSDIKTRPT CCCCCCCCCCCCCCC	45.78	-
1252	Phosphorylation	SDNSDIKTRPTPVKG CCCCCCCCCCCCCCC	42.06	-
1286	Phosphorylation	EARRLDRTPSQQSNI HHHCCCCCHHHHCCC	27.27	29899451
1288	Phosphorylation	RRLDRTPSQQSNILD HCCCCCHHHHCCCCC	39.99	29899451
1291	Phosphorylation	DRTPSQQSNILDNGQ CCCHHHHCCCCCCCC	20.43	29899451
1302	Phosphorylation	DNGQEDVSPSGQWNP CCCCCCCCCCCCCCC	26.18	22807455
1328	Phosphorylation	TITKKAGSHIQTLMG HHHHHCHHHHHHHHC	23.44	21183079
1336	Phosphorylation	HIQTLMGSQSLQHRS HHHHHHCCHHHHCCC	11.57	22324799
1338	Phosphorylation	QTLMGSQSLQHRSRE HHHHCCHHHHCCCCC	31.52	22324799
1343	Phosphorylation	SQSLQHRSREQQPYE CHHHHCCCCCCCCCC	37.74	25521595
1349	Phosphorylation	RSREQQPYEGNINKV CCCCCCCCCCCCCEE	31.93	-
1392	Phosphorylation	IQTKGQRSMDGYPEQ EEECCCCCCCCCCCC	17.21	25521595
1396	Phosphorylation	GQRSMDGYPEQFCVR CCCCCCCCCCCEEEE	10.18	22807455

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LRRC7_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LRRC7_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LRRC7_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of LRRC7_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LRRC7_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-850; THR-865; SER-949AND SER-1392, AND MASS SPECTROMETRY.	17114649 [Abstract]
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-850; SER-933; SER-949AND SER-1392, AND MASS SPECTROMETRY.	16452087 [Abstract]