CACB3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CACB3_MOUSE
• UniProt AC: P54285
• Protein Name: Voltage-dependent L-type calcium channel subunit beta-3
• Gene Name: Cacnb3
• Organism: Mus musculus (Mouse).
• Sequence Length: 484
• Protein Description: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting..
• Protein Sequence: MYDDSYVPGFEDSEAGSADSYTSRPSLDSDVSLEEDRESARREVESQAQQQLERAKHKPVAFAVRTNVSYCGVLDEECPVQGSGVNFEAKDFLHIKEKYSNDWWIGRLVKEGGDIAFIPSPQRLESIRLKQEQKARRSGNPSSLGDIGNRRSPPPSLAKQKQKQAEHVPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADLSLAKRSVLNNPGKRTIIERSSARSSIAEVQSEIERIFELAKSLQLVVLDADTINHPAQLAKTSLAPIIVFVKVSSPKVLQRLIRSRGKSQMKHLTVQMMAYDKLVQCPPESFDVILDENQLEDACEHLAEYLEVYWRATHHPAPGPGLLGPPSAIPGLQNQQLLGERVEEHSPLERDSLMPSDEASESSRQAWTGSSQRSSRHLEEDYADAYQDLYQPHRQHTSGLPSANGHDPQDRLLAQDSEHDHNDRNWQRNRPWPKDSY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
138	Phosphorylation	QEQKARRSGNPSSLG HHHHHHHCCCCCCCC	37.05	29899451
142	Phosphorylation	ARRSGNPSSLGDIGN HHHCCCCCCCCCCCC	42.04	29899451
143	Phosphorylation	RRSGNPSSLGDIGNR HHCCCCCCCCCCCCC	37.31	26643407
152	Phosphorylation	GDIGNRRSPPPSLAK CCCCCCCCCCHHHHH	37.19	25521595
156	Phosphorylation	NRRSPPPSLAKQKQK CCCCCCHHHHHHHHH	46.89	30372032
186	Phosphorylation	PVVLVGPSLKGYEVT CEEEECCCCCCCCHH	36.46	-
393	Phosphorylation	GERVEEHSPLERDSL CHHHHHCCCCCCCCC	34.16	25521595
399	Phosphorylation	HSPLERDSLMPSDEA CCCCCCCCCCCCCHH	32.56	20415495
403	Phosphorylation	ERDSLMPSDEASESS CCCCCCCCCHHCHHH	33.83	25521595
407	Phosphorylation	LMPSDEASESSRQAW CCCCCHHCHHHHHHH	35.64	25521595
409	Phosphorylation	PSDEASESSRQAWTG CCCHHCHHHHHHHHC	28.46	20415495
410	Phosphorylation	SDEASESSRQAWTGS CCHHCHHHHHHHHCC	25.10	21082442
415	Phosphorylation	ESSRQAWTGSSQRSS HHHHHHHHCCCHHHH	30.15	29899451
417	Phosphorylation	SRQAWTGSSQRSSRH HHHHHHCCCHHHHHH	18.87	29899451
418	Phosphorylation	RQAWTGSSQRSSRHL HHHHHCCCHHHHHHH	30.84	29899451
421	Phosphorylation	WTGSSQRSSRHLEED HHCCCHHHHHHHCHH	24.88	29899451
422	Phosphorylation	TGSSQRSSRHLEEDY HCCCHHHHHHHCHHH	26.38	29899451
429	Phosphorylation	SRHLEEDYADAYQDL HHHHCHHHHHHHHHH	15.06	29899451
464	Phosphorylation	DRLLAQDSEHDHNDR HCHHHCCCCCCCCCC	25.42	22324799
464	O-linked_Glycosylation	DRLLAQDSEHDHNDR HCHHHCCCCCCCCCC	25.42	31438931
483	Phosphorylation	NRPWPKDSY------ CCCCCCCCC------	38.58	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CACB3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CACB3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CACB3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CACB3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.