PQBP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PQBP1_MOUSE
• UniProt AC: Q91VJ5
• Protein Name: Polyglutamine-binding protein 1
• Gene Name: Pqbp1
• Organism: Mus musculus (Mouse).
• Sequence Length: 263
• Subcellular Localization: Nucleus . Nucleus speckle . Cytoplasmic granule . Colocalizes with SRSF2 in nuclear speckles (PubMed:23512658). Colocalized with POU3F2. Colocalized with ATXN1 in nuclear inclusion bodies. Localizes to cytoplasmic stress granules (By similarity).
• Protein Description: Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development (By similarity). Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species. [PubMed: 23512658 May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner (By similarity Can activate transcription directly or via association with the transcription machinery (By similarity May be involved in ATXN1 mutant-induced cell death (By similarity The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit (By similarity Involved in the assembly of cytoplasmic stress granule, possibly by participating to the transport of neuronal RNA granules (By similarity Also acts as an innate immune sensor of infection by retroviruses, by detecting the presence of reverse-transcribed DNA in the cytosol (By similarity Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production (By similarity]
• Protein Sequence: MPLPVALQTRLAKRGILKHLEPEPEEEIIAEDYDDDPVDYEATRIEGLPPSWYKVFDPSCGLPYYWNVETDLVSWLSPHDPNFVVTKSAKKVRNNNADAEDKSDRNLEKVDRNHEKSDRSHEKPDRSHEKADRNHEKNDRERERNYDKVDRERDRDRERERAFDKADREEGKDRRHHRREELAPYPKNKKATSRKDEELDPMDPSSYSDAPRGTWSTGLPKRNEAKTGADTTAAGPLFQQRPYPSPGAVLRANAEASRTKQQD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	EEIIAEDYDDDPVDY HHCCCCCCCCCCCCH	16.87	25159016
214	Phosphorylation	YSDAPRGTWSTGLPK CCCCCCCCCCCCCCC	19.95	20495213
231	Phosphorylation	EAKTGADTTAAGPLF CCCCCCCCCCCCHHH	20.14	26643407
232	Phosphorylation	AKTGADTTAAGPLFQ CCCCCCCCCCCHHHH	18.30	26643407
243	Phosphorylation	PLFQQRPYPSPGAVL HHHHCCCCCCCCHHH	20.66	26239621
245	Phosphorylation	FQQRPYPSPGAVLRA HHCCCCCCCCHHHHH	30.07	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PQBP1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PQBP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PQBP1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RED_HUMAN	IK	physical	26496610
MFAP1_HUMAN	MFAP1	physical	26496610
SNUT1_HUMAN	SART1	physical	26496610
PRP4_HUMAN	PRPF4	physical	26496610
PRPF3_HUMAN	PRPF3	physical	26496610
U5S1_HUMAN	EFTUD2	physical	26496610
SNR40_HUMAN	SNRNP40	physical	26496610
TOPRS_HUMAN	TOPORS	physical	26496610
PRP8_HUMAN	PRPF8	physical	26496610
LSM6_HUMAN	LSM6	physical	26496610
WBP4_HUMAN	WBP4	physical	26496610
U520_HUMAN	SNRNP200	physical	26496610
PRP6_HUMAN	PRPF6	physical	26496610
PRP31_HUMAN	PRPF31	physical	26496610
CFA20_HUMAN	CFAP20	physical	26496610
WBP11_HUMAN	WBP11	physical	26496610
SMU1_HUMAN	SMU1	physical	26496610
DEN4C_HUMAN	DENND4C	physical	26496610
RBM22_HUMAN	RBM22	physical	26496610
ASF1B_HUMAN	ASF1B	physical	26496610
UBL5_HUMAN	UBL5	physical	26496610
TOE1_HUMAN	TOE1	physical	26496610
TOP1M_HUMAN	TOP1MT	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.