DLG3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DLG3_MOUSE
• UniProt AC: P70175
• Protein Name: Disks large homolog 3
• Gene Name: Dlg3
• Organism: Mus musculus (Mouse).
• Sequence Length: 849
• Protein Description: Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling..
• Protein Sequence: MHKHQHCCKCPECYEVTRLAALRRLEPPGYGDWQVPDPYGPSGGNGASSGYGGYSSQTLPSQAGATPTPRTKAKLIPTGRDVGPVPPKPVPGKSTPKLNGSGPGWWPECTCTNRDWYEQASPAPLLVNPEALEPSLSVNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSIHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVTYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHARTGMIESNRDFPGLSDDYYGAKNLKGVTSNTSDSESSSKGQEDAILSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQANKIFDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPSPEKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
95	Phosphorylation	KPVPGKSTPKLNGSG CCCCCCCCCCCCCCC	28.12	-
157	Phosphorylation	IVLERGNSGLGFSIA EEEECCCCCCCCEEE	37.91	22817900
286	Ubiquitination	IEGGAAQKDGRLQIG EECCCCCCCCCCEEC	58.38	-
324	Phosphorylation	KNTSDMVYLKVAKPG CCCCCCEEEEECCCC	8.31	-
383	Phosphorylation	APPQVPPTRYSPIPR CCCCCCCCCCCCCCH	35.85	29899451
385	Phosphorylation	PQVPPTRYSPIPRHM CCCCCCCCCCCCHHH	22.68	21454597
386	Phosphorylation	QVPPTRYSPIPRHML CCCCCCCCCCCHHHC	17.05	30372032
505	Phosphorylation	LREQMMNSSMSSGSG HHHHHHHCCCCCCCC	14.99	29899451
506	Phosphorylation	REQMMNSSMSSGSGS HHHHHHCCCCCCCCC	20.06	29899451
508	Phosphorylation	QMMNSSMSSGSGSLR HHHHCCCCCCCCCCC	33.23	29899451
509	Phosphorylation	MMNSSMSSGSGSLRT HHHCCCCCCCCCCCC	28.47	25521595
511	Phosphorylation	NSSMSSGSGSLRTSE HCCCCCCCCCCCCHH	27.44	25521595
513	Phosphorylation	SMSSGSGSLRTSEKR CCCCCCCCCCCHHCC	19.17	25521595
521	Phosphorylation	LRTSEKRSLYVRALF CCCHHCCHHHHHHHC	34.81	-
523	Phosphorylation	TSEKRSLYVRALFDY CHHCCHHHHHHHCCC	6.80	25521595
533	Phosphorylation	ALFDYDRTRDSCLPS HHCCCCCCCCCCCCC	35.61	25521595
557	Phosphorylation	ILHVINASDDEWWQA EEEEEECCCCCCEEE	40.90	22817900
581	Phosphorylation	EQIGVIPSKKRVEKK HHCCCCCCCCCCCHH	39.42	22817900
607	Phosphorylation	ARTGMIESNRDFPGL HHCCCCCCCCCCCCC	26.66	-
615	Phosphorylation	NRDFPGLSDDYYGAK CCCCCCCCCCCCCCC	34.06	-
628	Phosphorylation	AKNLKGVTSNTSDSE CCCCCCCCCCCCCCC	25.57	29899451
629	Phosphorylation	KNLKGVTSNTSDSES CCCCCCCCCCCCCCC	35.39	29899451
631	Phosphorylation	LKGVTSNTSDSESSS CCCCCCCCCCCCCCC	33.41	29550500
632	Phosphorylation	KGVTSNTSDSESSSK CCCCCCCCCCCCCCC	43.31	25521595
634	Phosphorylation	VTSNTSDSESSSKGQ CCCCCCCCCCCCCCC	38.86	20415495
636	Phosphorylation	SNTSDSESSSKGQED CCCCCCCCCCCCCCC	43.81	20415495
637	Phosphorylation	NTSDSESSSKGQEDA CCCCCCCCCCCCCCE	31.83	19060867
638	Phosphorylation	TSDSESSSKGQEDAI CCCCCCCCCCCCCEE	50.51	29899451
647	Phosphorylation	GQEDAILSYEPVTRQ CCCCEEEEECCCCHH	22.72	29899451
705	Phosphorylation	NEVDGQDYHFVVSRE CCCCCCEEEEEEEHH	6.83	27899381
761	Ubiquitination	DVSGNAIKRLQQAQL ECCCHHHHHHHHCCC	44.65	-
791	Phosphorylation	MEMNRRQTYEQANKI HHHHHHHHHHHHHHH	27.49	29514104
845	Phosphorylation	GHYIWVPSPEKL--- CCEEEECCCCCC---	35.75	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DLG3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DLG3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DLG3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NEDD4_MOUSE	Nedd4	physical	21920314
PP1G_MOUSE	Ppp1cc	physical	21920314
TJAP1_MOUSE	Tjap1	physical	21920314
DC1I1_MOUSE	Dync1i1	physical	21920314
DLG2_MOUSE	Dlg2	physical	21920314
N4BP3_MOUSE	N4bp3	physical	21920314

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-705, AND MASSSPECTROMETRY.
PubMed: 18034455