HOME2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HOME2_MOUSE
• UniProt AC: Q9QWW1
• Protein Name: Homer protein homolog 2 {ECO:0000305}
• Gene Name: Homer2 {ECO:0000312|MGI:MGI:1347354}
• Organism: Mus musculus (Mouse).
• Sequence Length: 354
• Subcellular Localization: Cytoplasm . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Cell projection, stereocilium . Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate recep
• Protein Description: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2 (By similarity). Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (By similarity) Required for normal hearing. [PubMed: 25816005 Negatively regulates T cell activation through negative regulation of IL2 expression by inhibiting calcineurin-NFAT pathway activation through interaction with NFATC2 (By similarity]
• Protein Sequence: MGEQPIFTTRAHVFQIDPSTKKNWVPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSELQLTKFAEKFQEVREAARLARDKSQEKTETSSNHSQESGCETPSSTQASSVNGTDDEKASHASPADTHLKSENDKLKIALTQSAANVKKWEMELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRSKIEELEEQCSEINREKEKNTQLKRRIEELESEVRDKEMELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKGELKSFLEVLDGKIDDLHDFRRGLSKLGTDN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
117	Phosphorylation	ARLARDKSQEKTETS HHHHHHHHHHCCCCC	48.11	-
123	Phosphorylation	KSQEKTETSSNHSQE HHHHCCCCCCCCCCC	42.56	-
131	Phosphorylation	SSNHSQESGCETPSS CCCCCCCCCCCCCCC	40.90	-
156	Phosphorylation	DEKASHASPADTHLK CCHHCCCCCCHHCCC	18.39	29899451
216	Phosphorylation	EQWKRQFSICRDEND HHHHHHHHHHCCCHH	16.67	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
216	S	Phosphorylation	Kinase	CAMK2A	P11798	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HOME2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HOME2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RHOA_MOUSE	Rhoa	physical	10493740
RAC1_MOUSE	Rac1	physical	10493740
CDC42_MOUSE	Cdc42	physical	10493740
CAZA1_MOUSE	Capza1	physical	10493740
GRM1_MOUSE	Grm1	physical	10493740
DLG4_MOUSE	Dlg4	physical	10493740
SYPH_MOUSE	Syp	physical	10493740
GRM5_MOUSE	Grm5	physical	9808458
HOME1_RAT	Homer1	physical	9808458

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.