dbPTM

SIK3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SIK3_MOUSE
UniProt AC	Q6P4S6
Protein Name	Serine/threonine-protein kinase SIK3
Gene Name	Sik3
Organism	Mus musculus (Mouse).
Sequence Length	1311
Subcellular Localization	Cytoplasm. Locates to punctate structures within the cytoplasm on binding to YWHAZ..
Protein Description
Protein Sequence	MAARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKSQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICRHKWMKLGDADPNFDRLIAECQQLKEERQSDPLNDDVLLAMEDMGLDKERTLQSLRSDAYDHYSAIYSLLCDRHKKHKTLRPGALPSMPQAMTFQAPVNLQAEQTGTAMNLSVPQVQLINPENQIIEPDGAVNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQGPFLQVAPNMNFTHNLLPMQSLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQRYLANRSKRHTLAMTSPTAEIPPDLQRQLGQQSFRSRVWPPHLVPDQHRSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNSSSIKQLQQECEQLQKMYGGQVDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQVACENQPALLTHQLQRLRIQPSSPPPNHPSNHLFRQPSNSPPPVSSAMITSHGATSPSQFQGLPSHGAIFQQQPENCSPPPSVALTCLGLQQASQSQPVTIQLQEPVDMLSNMAGTAAGSAGRSIPISPSASQIQIQHRASLMAPFSYGHRPLSKQLSADSAEAHSLNMNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFPPTQALKVPPLDQFPTFPPSAQQQPPHYTTSALQQALLSPTPPDYPRHQQVPHILQGLLSPRHSLTGHSDIRLPPAEFAQLIKRQQQHRQQQQQQQQQQEYHELFRHMNQGDAVSLAPSLGGQNMTEHQALSYQNADSYHRHHTSPQHILQIRAQDCISQGPSPTPTHGYAHQPPLMHSESMEEDCLCEGLKEGFPDKSSSTLTKGCHNSPLLLCTSGPGDPEPLLGTVSQARELGIHPYGHQPTATTFSRNKVPSRESVLGNCLERSSPGQAMELPDHNGLGYPVRPLVSEHLRSRTLQRHHTIQNSDDAYVQLDTLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDEEDEECGVSLGHEHPGLGDGSQHLNSSRYPATCVTDIMLSHKHPEVSFSMEQAGV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MAARIGYYEIDRTI -CCCCEEEEEEECCC	8.78	29899451
13	Phosphorylation	GYYEIDRTIGKGNFA EEEEEECCCCCCCEE	30.27	22807455
116	Phosphorylation	RKFKQIVTAVYFCHC HHHHHHHHHHHHHHH	16.43	21183079
152	Phosphorylation	KIADFGFSNLFTPGQ EECCCCCCCCCCHHH	32.76	26745281
156	Phosphorylation	FGFSNLFTPGQLLKT CCCCCCCCHHHHHHH	29.67	26745281
163	Phosphorylation	TPGQLLKTWCGSPPY CHHHHHHHHCCCCCC	26.42	25521595
167	Phosphorylation	LLKTWCGSPPYAAPE HHHHHCCCCCCCCHH	21.40	25521595
170	Phosphorylation	TWCGSPPYAAPELFE HHCCCCCCCCHHHHC	20.84	25521595
279	Acetylation	IAECQQLKEERQSDP HHHHHHHHHHHCCCC	53.87	22826441
308	Phosphorylation	DKERTLQSLRSDAYD CHHHHHHHHHHHHHH	28.94	28973931
361	Phosphorylation	LQAEQTGTAMNLSVP EEEHHHCCCCCCCCC	26.56	23649490
411	Phosphorylation	YLSMRRHTVGVADPR HHHHHCCCCCCCCCC	19.69	25521595
462 (in isoform 2)	Phosphorylation	-	43.73	28285833
472	Phosphorylation	QLEYKEQSLLQPPTL CCEEHHHHCCCCCCH	31.94	28285833
476 (in isoform 2)	Phosphorylation	-	24.66	25521595
493	Phosphorylation	GPLGRRASDGGANIQ CCCCCCCCCCCCHHH	34.67	27087446
514	Phosphorylation	LKRPRGPSPLVTMTP HCCCCCCCCCCEECC	33.42	21659605
518	Phosphorylation	RGPSPLVTMTPAVPA CCCCCCCEECCCCCC	24.02	24925903
520	Phosphorylation	PSPLVTMTPAVPAVT CCCCCEECCCCCCCC	9.95	24925903
527	Phosphorylation	TPAVPAVTPVDEESS CCCCCCCCCCCCCCC	21.50	24925903
533	Phosphorylation	VTPVDEESSDGEPDQ CCCCCCCCCCCCCCH	31.51	25521595
534	Phosphorylation	TPVDEESSDGEPDQE CCCCCCCCCCCCCHH	53.57	25521595
551	Phosphorylation	QRYLANRSKRHTLAM HHHHHHHHHCCEEEE	33.57	22807455
555	Phosphorylation	ANRSKRHTLAMTSPT HHHHHCCEEEECCCC	21.90	27600695
559	Phosphorylation	KRHTLAMTSPTAEIP HCCEEEECCCCCCCC	26.41	25266776
560	Phosphorylation	RHTLAMTSPTAEIPP CCEEEECCCCCCCCH	13.73	22942356
562	Phosphorylation	TLAMTSPTAEIPPDL EEEECCCCCCCCHHH	36.37	22942356
577	Phosphorylation	QRQLGQQSFRSRVWP HHHHCCCCHHHCCCC	18.10	29514104
580	Phosphorylation	LGQQSFRSRVWPPHL HCCCCHHHCCCCCCC	29.22	29514104
591	Phosphorylation	PPHLVPDQHRSTYKD CCCCCCCCCCCCCCC	28.02	24719451
606	Phosphorylation	SNTLHLPTERFSPVR CCCCCCCCCCCCCCC	46.26	26824392
610	Phosphorylation	HLPTERFSPVRRFSD CCCCCCCCCCCCCCC	28.80	26824392
616	Phosphorylation	FSPVRRFSDGAASIQ CCCCCCCCCCHHHHH	33.07	25521595
621	Phosphorylation	RFSDGAASIQAFKAH CCCCCHHHHHHHHHH	18.07	28833060
635	Phosphorylation	HLEKMGNSSSIKQLQ HHHHCCCCHHHHHHH	21.52	26160508
636	Phosphorylation	LEKMGNSSSIKQLQQ HHHCCCCHHHHHHHH	39.83	25266776
637	Phosphorylation	EKMGNSSSIKQLQQE HHCCCCHHHHHHHHH	33.36	24453211
668	Phosphorylation	LEKTQQQHMLYQQEQ HHHHHHHHHHHHHHH	12.13	24719451
693	Phosphorylation	DSICPPQPSPPLQVA HHCCCCCCCCCCCHH	55.36	24719451
720	Phosphorylation	QRLRIQPSSPPPNHP HHCCCCCCCCCCCCC	38.82	30352176
721	Phosphorylation	RLRIQPSSPPPNHPS HCCCCCCCCCCCCCC	48.38	26824392
728	Phosphorylation	SPPPNHPSNHLFRQP CCCCCCCCCCCCCCC	29.36	23737553
778	Phosphorylation	QPENCSPPPSVALTC CCCCCCCCCCHHHHH	19.94	24719451
822	Phosphorylation	AAGSAGRSIPISPSA CCCCCCCCCCCCCCH	31.62	28833060
826	Phosphorylation	AGRSIPISPSASQIQ CCCCCCCCCCHHHCE	13.88	28833060
828	Phosphorylation	RSIPISPSASQIQIQ CCCCCCCCHHHCEEE	33.49	22322096
830	Phosphorylation	IPISPSASQIQIQHR CCCCCCHHHCEEEEC	31.96	28066266
856	Phosphorylation	RPLSKQLSADSAEAH CCHHHCCCCCHHHHH	27.77	25521595
859	Phosphorylation	SKQLSADSAEAHSLN HHCCCCCHHHHHCCC	27.94	22942356
864	Phosphorylation	ADSAEAHSLNMNRFS CCHHHHHCCCCCCCC	28.61	28833060
889	O-linked_Glycosylation	PHLFSDQSRGSPSSY HHHCCCCCCCCCCCC	43.53	55413483
914	Phosphorylation	TQALKVPPLDQFPTF CCCCCCCCHHHCCCC	52.11	24719451
964	Phosphorylation	HILQGLLSPRHSLTG HHHHHHCCCCCCCCC	25.57	26824392
968	Phosphorylation	GLLSPRHSLTGHSDI HHCCCCCCCCCCCCC	28.98	26824392
970	Phosphorylation	LSPRHSLTGHSDIRL CCCCCCCCCCCCCCC	35.54	28066266
973	Phosphorylation	RHSLTGHSDIRLPPA CCCCCCCCCCCCCHH	35.76	28066266
976	Methylation	LTGHSDIRLPPAEFA CCCCCCCCCCHHHHH	46.24	24129315
1048	Phosphorylation	DSYHRHHTSPQHILQ CCCCCCCCCHHHHHH	35.66	27841257
1049	Phosphorylation	SYHRHHTSPQHILQI CCCCCCCCHHHHHHH	20.43	25266776
1067	Phosphorylation	DCISQGPSPTPTHGY HHHHCCCCCCCCCCC	48.51	29899451
1083	Phosphorylation	HQPPLMHSESMEEDC CCCCCCCCCCHHHHH	19.87	30352176
1114	Phosphorylation	LTKGCHNSPLLLCTS CCCCCCCCCEEEEEC	8.02	28066266
1120	Phosphorylation	NSPLLLCTSGPGDPE CCCEEEEECCCCCCC	36.37	28066266
1121	Phosphorylation	SPLLLCTSGPGDPEP CCEEEEECCCCCCCC	41.83	28066266
1160	Phosphorylation	FSRNKVPSRESVLGN CCCCCCCCHHHHHHH	52.23	26824392
1163	Phosphorylation	NKVPSRESVLGNCLE CCCCCHHHHHHHHHH	22.87	26824392
1208	Phosphorylation	RTLQRHHTIQNSDDA HHHHHHHCCCCCCCC	20.38	19060867
1212	Phosphorylation	RHHTIQNSDDAYVQL HHHCCCCCCCCEEEC	22.08	21183079
1216	Phosphorylation	IQNSDDAYVQLDTLP CCCCCCCEEECCCCC	8.84	22807455
1221	Phosphorylation	DAYVQLDTLPGMSLV CCEEECCCCCCCHHH	43.37	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
493	S	Phosphorylation	Kinase	PKACA	P05132	PSP
551	S	Phosphorylation	Kinase	PKACA	P05132	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
163	T	Phosphorylation		21183079
Phosphorylated at Thr-163 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SIK3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SIK3_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SIK3_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-493 AND SER-616, ANDMASS SPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-533 AND SER-534, ANDMASS SPECTROMETRY.	17242355 [Abstract]

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