UniProt ID | SHAN2_MOUSE | |
---|---|---|
UniProt AC | Q80Z38 | |
Protein Name | SH3 and multiple ankyrin repeat domains protein 2 | |
Gene Name | Shank2 | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 1476 | |
Subcellular Localization | Apical cell membrane. Cytoplasm . Cell junction, synapse . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Cell projection, dendritic spine . Cell projection, growth cone. Colocalizes with cortactin in growth cones in diffe | |
Protein Description | Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction (By similarity).. | |
Protein Sequence | MKSLLNAFTKKEVPFREAPAYSNRRRRPPNTLAAPRVLLRSNSDNNLNAGAPEWAVCSAATSHRSLSPQLLQQTPSKPDGATKSLGSYTPGPRSRSPSLNRLGGTAEDGKRTQPHWHVGSPFTPGANKDSLSTFEYPGPRRKLYSAVPGRLFVAVKPYQPQVDGEIPLHRGDRVKVLSIGEGGFWEGSARGHIGWFPAECVEEVQCKPRDSQAETRADRSKKLFRHYTVGSYDSFDAASDCIIEDKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLILKVVTVTRNLDPDDTARKKAPPPPKRAPTTALTLRSKSMTAELEELGLSLVDKASVRKKKDKPEEIVPASKPSRTAENVAIESRVATIKQRPTSRCFPAASDVNSVYERQGIAVMTPTVPGSPKGPFLGLPRGTMRRQKSIDSRIFLSGITEEERQFLAPPMLKFTRSLSMPDTSEDIPPPPQSVPPSPPPPSPTTYNCPRSPTPRVYGTIKPAFNQNPVVAKVPPATRSDTVATMMREKGMFYRRELDRFSLDSEDVYSRSPAPQAAFRTKRGQMPENPYSEVGKIASKAVYVPAKPARRKGVLVKQSNVEDSPEKTCSIPIPTIIVKEPSTSSSGKSSQGSSMEIDPQATEPGQLRPDDSLTVSSPFAAAIAGAVRDREKRLEARRNSPAFLSTDLGDEDVGLGPPAPRMQASKFPEEGGFGDEDETEQPLLPTPGAAPRELENHFLGGGEAGAQGEAGGPLSSTSKAKGPESGPAAPLKSSSPAGPENYVHPLTGRLLDPSSPLALALSARDRAMQESQQGHKGEAPKADLNKPLYIDTKMRPSVESGFPPVTRQNTRGPLRRQETENKYETDLGKDRRADDKKNMLINIVDTAQQKSAGLLMVHTVDVPMAGPPLEEEEDREDGDTKPDHSPSTVPEGVPKTEGALQISAAPEPAVAPGRTIVAAGSVEEAVILPFRIPPPPLASVDLDEDFLFTEPLPPPLEFANSFDIPDDRAASVPALADLVKQKKNDTSQPPTLNSSQPANSTDSKKPAGISNCLPSSFLPPPESFDAVTDSGIEEVDSRSSSDHHLETTSTISTVSSISTLSSEGGESMDTCTVYADGQAFVVDKPPVPPKPKMKPIVHKSNALYQDTLPEEDTDGFVIPPPAPPPPPGSAQAGVAKVIQPRTSKLWGDVPEVKSPILSGPKANVISELNSILQQMNRGKSVKPGEGLELPVGAKSANLAPRSPEVMSTVSGTRSTTVTFTVRPGTSQPITLQSRPPDYESRTSGPRRAPSPVVSPTELSKEILPTPPPPSATAASPSPTLSDVFSLPSQSPAGDLFGLNPAGRSRSPSPSILQQPISNKPFTTKPVHLWTKPDVADWLESLNLGEHKETFMDNEIDGSHLPNLQKEDLIDLGVTRVGHRMNIERALKQLLDR | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
15 | Phosphorylation | FTKKEVPFREAPAYS HHCCCCCCCCCCCCC | 15.47 | - | |
15 (in isoform 3) | Phosphorylation | - | 15.47 | 22807455 | |
17 (in isoform 3) | Phosphorylation | - | 60.42 | 21183079 | |
26 (in isoform 3) | Phosphorylation | - | 52.82 | 27841257 | |
41 | Phosphorylation | APRVLLRSNSDNNLN CCEEEECCCCCCCCC | 40.43 | 25521595 | |
43 | Phosphorylation | RVLLRSNSDNNLNAG EEEECCCCCCCCCCC | 42.85 | 26643407 | |
65 | Phosphorylation | SAATSHRSLSPQLLQ HHHCCCCCCCHHHHH | 27.98 | 26643407 | |
67 | Phosphorylation | ATSHRSLSPQLLQQT HCCCCCCCHHHHHCC | 16.31 | 26239621 | |
88 | Phosphorylation | ATKSLGSYTPGPRSR CCCCCCCCCCCCCCC | 18.37 | 23984901 | |
89 | Phosphorylation | TKSLGSYTPGPRSRS CCCCCCCCCCCCCCC | 24.38 | 23984901 | |
94 | Phosphorylation | SYTPGPRSRSPSLNR CCCCCCCCCCCCCCC | 40.00 | 29514104 | |
96 | Phosphorylation | TPGPRSRSPSLNRLG CCCCCCCCCCCCCCC | 21.78 | 29899451 | |
144 | Phosphorylation | PGPRRKLYSAVPGRL CCCCHHHEEECCCCE | 9.53 | - | |
160 | Phosphorylation | VAVKPYQPQVDGEIP EEECCCCCCCCCCCC | 30.25 | - | |
160 (in isoform 3) | Phosphorylation | - | 30.25 | 22807455 | |
162 | Phosphorylation | VKPYQPQVDGEIPLH ECCCCCCCCCCCCCC | 15.07 | - | |
162 (in isoform 3) | Phosphorylation | - | 15.07 | 25521595 | |
164 (in isoform 3) | Phosphorylation | - | 35.56 | 22324799 | |
175 (in isoform 3) | Phosphorylation | - | 38.05 | 29899451 | |
227 | Phosphorylation | SKKLFRHYTVGSYDS HHHHHHHCCCCCCCC | 10.00 | 29899451 | |
228 | Phosphorylation | KKLFRHYTVGSYDSF HHHHHHCCCCCCCCC | 16.56 | 29899451 | |
231 | Phosphorylation | FRHYTVGSYDSFDAA HHHCCCCCCCCCCCH | 22.79 | 29899451 | |
232 | Phosphorylation | RHYTVGSYDSFDAAS HHCCCCCCCCCCCHH | 15.07 | 29899451 | |
234 | Phosphorylation | YTVGSYDSFDAASDC CCCCCCCCCCCHHCE | 19.45 | 19060867 | |
363 | Phosphorylation | PPPKRAPTTALTLRS CCCCCCCCCEEHHCC | 24.58 | 20415495 | |
367 | Phosphorylation | RAPTTALTLRSKSMT CCCCCEEHHCCCCCC | 20.05 | 20415495 | |
370 | Phosphorylation | TTALTLRSKSMTAEL CCEEHHCCCCCCHHH | 31.99 | 19060867 | |
370 (in isoform 2) | Phosphorylation | - | 31.99 | 22807455 | |
372 | Phosphorylation | ALTLRSKSMTAELEE EEHHCCCCCCHHHHH | 23.70 | 19060867 | |
372 (in isoform 2) | Phosphorylation | - | 23.70 | 25521595 | |
374 | Phosphorylation | TLRSKSMTAELEELG HHCCCCCCHHHHHHC | 24.87 | 19060867 | |
374 (in isoform 2) | Phosphorylation | - | 24.87 | 22324799 | |
385 (in isoform 2) | Phosphorylation | - | 6.79 | 29899451 | |
404 | O-linked_Glycosylation | PEEIVPASKPSRTAE CHHHCCCCCCCCCHH | 38.74 | 30059200 | |
427 | O-linked_Glycosylation | ATIKQRPTSRCFPAA EECCCCCCCCCCCCH | 30.87 | 30059200 | |
450 | Phosphorylation | RQGIAVMTPTVPGSP HCCEEEECCCCCCCC | 14.81 | 28066266 | |
452 | Phosphorylation | GIAVMTPTVPGSPKG CEEEECCCCCCCCCC | 30.11 | 26643407 | |
456 | Phosphorylation | MTPTVPGSPKGPFLG ECCCCCCCCCCCCCC | 19.85 | 25521595 | |
474 | Phosphorylation | GTMRRQKSIDSRIFL CCCCCCCCCCHHHHH | 24.24 | 22324799 | |
477 | Phosphorylation | RRQKSIDSRIFLSGI CCCCCCCHHHHHCCC | 26.13 | 22324799 | |
482 | Phosphorylation | IDSRIFLSGITEEER CCHHHHHCCCCHHHH | 19.87 | 22324799 | |
485 | O-linked_Glycosylation | RIFLSGITEEERQFL HHHHCCCCHHHHHHH | 40.65 | 145269 | |
485 | Phosphorylation | RIFLSGITEEERQFL HHHHCCCCHHHHHHH | 40.65 | 22324799 | |
502 | Phosphorylation | PMLKFTRSLSMPDTS CCHHHHCCCCCCCCC | 23.03 | 19060867 | |
509 | Phosphorylation | SLSMPDTSEDIPPPP CCCCCCCCCCCCCCC | 40.42 | 24759943 | |
518 | Phosphorylation | DIPPPPQSVPPSPPP CCCCCCCCCCCCCCC | 42.22 | 21183079 | |
522 | Phosphorylation | PPQSVPPSPPPPSPT CCCCCCCCCCCCCCC | 43.92 | 22807455 | |
529 | Phosphorylation | SPPPPSPTTYNCPRS CCCCCCCCCCCCCCC | 46.37 | 28576409 | |
542 | Phosphorylation | RSPTPRVYGTIKPAF CCCCCCCCCEECCHH | 15.16 | 29899451 | |
562 | O-linked_Glycosylation | VAKVPPATRSDTVAT EEECCCCCCCHHHHH | 36.16 | 30059200 | |
566 | Phosphorylation | PPATRSDTVATMMRE CCCCCCHHHHHHHHH | 17.18 | 25521595 | |
586 | Phosphorylation | RRELDRFSLDSEDVY EHHCCCCCCCCHHCC | 31.96 | 25521595 | |
589 | Phosphorylation | LDRFSLDSEDVYSRS CCCCCCCCHHCCCCC | 40.78 | 26239621 | |
593 | Phosphorylation | SLDSEDVYSRSPAPQ CCCCHHCCCCCCCCH | 15.64 | 24925903 | |
594 | Phosphorylation | LDSEDVYSRSPAPQA CCCHHCCCCCCCCHH | 26.57 | 24925903 | |
615 | Phosphorylation | GQMPENPYSEVGKIA CCCCCCCHHHHHHHC | 29.10 | 29899451 | |
616 | Phosphorylation | QMPENPYSEVGKIAS CCCCCCHHHHHHHCC | 27.36 | 26643407 | |
643 | Phosphorylation | KGVLVKQSNVEDSPE CCEEEECCCCCCCCC | 36.81 | 20415495 | |
648 | Phosphorylation | KQSNVEDSPEKTCSI ECCCCCCCCCCCCCC | 22.81 | 25521595 | |
652 | Phosphorylation | VEDSPEKTCSIPIPT CCCCCCCCCCCCCCE | 15.15 | 20415495 | |
654 | Phosphorylation | DSPEKTCSIPIPTII CCCCCCCCCCCCEEE | 36.31 | 20415495 | |
659 | Phosphorylation | TCSIPIPTIIVKEPS CCCCCCCEEEEECCC | 24.85 | 20415495 | |
668 | Phosphorylation | IVKEPSTSSSGKSSQ EEECCCCCCCCCCCC | 27.18 | 29899451 | |
673 | Phosphorylation | STSSSGKSSQGSSME CCCCCCCCCCCCCCE | 31.27 | 29899451 | |
674 | Phosphorylation | TSSSGKSSQGSSMEI CCCCCCCCCCCCCEE | 41.89 | 29899451 | |
678 | Phosphorylation | GKSSQGSSMEIDPQA CCCCCCCCCEECCCC | 27.53 | 29899451 | |
724 | Phosphorylation | RLEARRNSPAFLSTD HHHHHHCCCCCCCCC | 18.78 | 24925903 | |
729 | Phosphorylation | RNSPAFLSTDLGDED HCCCCCCCCCCCCCC | 17.27 | 25521595 | |
730 | Phosphorylation | NSPAFLSTDLGDEDV CCCCCCCCCCCCCCC | 37.07 | 25521595 | |
817 | Phosphorylation | GPAAPLKSSSPAGPE CCCCCCCCCCCCCCC | 43.67 | 26643407 | |
818 | Phosphorylation | PAAPLKSSSPAGPEN CCCCCCCCCCCCCCC | 38.46 | 26643407 | |
819 | Phosphorylation | AAPLKSSSPAGPENY CCCCCCCCCCCCCCC | 26.34 | 26643407 | |
838 | Phosphorylation | TGRLLDPSSPLALAL CCCCCCCCCHHHHHH | 44.23 | - | |
839 | Phosphorylation | GRLLDPSSPLALALS CCCCCCCCHHHHHHH | 29.35 | - | |
881 | Phosphorylation | IDTKMRPSVESGFPP EECCCCCCHHHCCCC | 28.31 | 21189417 | |
884 | Phosphorylation | KMRPSVESGFPPVTR CCCCCHHHCCCCCCC | 43.51 | 24759943 | |
890 | O-linked_Glycosylation | ESGFPPVTRQNTRGP HHCCCCCCCCCCCCC | 32.10 | 55413759 | |
890 | Phosphorylation | ESGFPPVTRQNTRGP HHCCCCCCCCCCCCC | 32.10 | - | |
894 | Phosphorylation | PPVTRQNTRGPLRRQ CCCCCCCCCCCCCHH | 28.76 | - | |
903 | Phosphorylation | GPLRRQETENKYETD CCCCHHHHCCHHCCC | 36.20 | 25521595 | |
907 | Phosphorylation | RQETENKYETDLGKD HHHHCCHHCCCCCCC | 35.33 | 25521595 | |
980 | O-linked_Glycosylation | VPEGVPKTEGALQIS CCCCCCCCCCCEEEE | 33.31 | 30059200 | |
999 | Phosphorylation | PAVAPGRTIVAAGSV CCCCCCCEEEECCCC | 26.22 | - | |
1005 | Phosphorylation | RTIVAAGSVEEAVIL CEEEECCCCEEEEEE | 22.94 | 18056256 | |
1055 | Phosphorylation | IPDDRAASVPALADL CCCCHHHHHHHHHHH | 27.87 | 29899451 | |
1107 | Phosphorylation | SFLPPPESFDAVTDS HHCCCCHHHCCCCCC | 33.91 | 29899451 | |
1112 | Phosphorylation | PESFDAVTDSGIEEV CHHHCCCCCCCCCCC | 26.60 | 29899451 | |
1191 | Phosphorylation | SNALYQDTLPEEDTD CCCCCCCCCCCCCCC | 28.78 | 24759943 | |
1226 | Phosphorylation | AKVIQPRTSKLWGDV EEHHCCCCHHHCCCC | 36.58 | 21082442 | |
1227 | Phosphorylation | KVIQPRTSKLWGDVP EHHCCCCHHHCCCCC | 27.34 | 22807455 | |
1238 | Phosphorylation | GDVPEVKSPILSGPK CCCCCCCCCHHCCCC | 23.50 | 29899451 | |
1242 | Phosphorylation | EVKSPILSGPKANVI CCCCCHHCCCCHHHH | 54.49 | 23984901 | |
1264 | Phosphorylation | QQMNRGKSVKPGEGL HHHHCCCCCCCCCCC | 37.89 | 25521595 | |
1286 | Phosphorylation | SANLAPRSPEVMSTV CCCCCCCCHHHHHEE | 25.09 | 28066266 | |
1291 | O-linked_Glycosylation | PRSPEVMSTVSGTRS CCCHHHHHEECCCCE | 30.72 | 8522215 | |
1291 | Phosphorylation | PRSPEVMSTVSGTRS CCCHHHHHEECCCCE | 30.72 | - | |
1292 | O-linked_Glycosylation | RSPEVMSTVSGTRST CCHHHHHEECCCCEE | 10.70 | 30059200 | |
1292 | Phosphorylation | RSPEVMSTVSGTRST CCHHHHHEECCCCEE | 10.70 | - | |
1294 | O-linked_Glycosylation | PEVMSTVSGTRSTTV HHHHHEECCCCEEEE | 34.24 | 8522223 | |
1294 | Phosphorylation | PEVMSTVSGTRSTTV HHHHHEECCCCEEEE | 34.24 | - | |
1296 | O-linked_Glycosylation | VMSTVSGTRSTTVTF HHHEECCCCEEEEEE | 17.59 | 8522207 | |
1296 | Phosphorylation | VMSTVSGTRSTTVTF HHHEECCCCEEEEEE | 17.59 | - | |
1302 | O-linked_Glycosylation | GTRSTTVTFTVRPGT CCCEEEEEEEECCCC | 16.11 | 30059200 | |
1334 | Phosphorylation | SGPRRAPSPVVSPTE CCCCCCCCCCCCHHH | 29.37 | 25521595 | |
1338 | Phosphorylation | RAPSPVVSPTELSKE CCCCCCCCHHHHHHC | 26.74 | 25521595 | |
1340 | Phosphorylation | PSPVVSPTELSKEIL CCCCCCHHHHHHCCC | 41.89 | 25521595 | |
1343 | Phosphorylation | VVSPTELSKEILPTP CCCHHHHHHCCCCCC | 23.24 | 24925903 | |
1359 | Phosphorylation | PPSATAASPSPTLSD CCCCCCCCCCCCHHH | 24.36 | 29899451 | |
1361 | Phosphorylation | SATAASPSPTLSDVF CCCCCCCCCCHHHHH | 28.20 | 29899451 | |
1365 | Phosphorylation | ASPSPTLSDVFSLPS CCCCCCHHHHHCCCC | 33.92 | 29899451 | |
1388 | Phosphorylation | GLNPAGRSRSPSPSI CCCCCCCCCCCCCCH | 35.87 | 21743459 | |
1390 | Phosphorylation | NPAGRSRSPSPSILQ CCCCCCCCCCCCHHC | 30.86 | 21743459 | |
1392 | Phosphorylation | AGRSRSPSPSILQQP CCCCCCCCCCHHCCC | 32.31 | 21743459 | |
1394 | Phosphorylation | RSRSPSPSILQQPIS CCCCCCCCHHCCCCC | 40.02 | 21743459 | |
1401 | Phosphorylation | SILQQPISNKPFTTK CHHCCCCCCCCCCCC | 45.55 | 20469934 | |
1468 | Methylation | GHRMNIERALKQLLD HHHHCHHHHHHHHHC | 41.23 | 18959257 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SHAN2_MOUSE !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SHAN2_MOUSE !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SHAN2_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
Oops, there are no PPI records of SHAN2_MOUSE !! |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
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O-linked Glycosylation | |
Reference | PubMed |
"O-linked N-acetylglucosamine proteomics of postsynaptic densitypreparations using lectin weak affinity chromatography and massspectrometry."; Vosseller K., Trinidad J.C., Chalkley R.J., Specht C.G.,Thalhammer A., Lynn A.J., Snedecor J.O., Guan S., Medzihradszky K.F.,Maltby D.A., Schoepfer R., Burlingame A.L.; Mol. Cell. Proteomics 5:923-934(2006). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT THR-1292, AND MASSSPECTROMETRY. | |
Phosphorylation | |
Reference | PubMed |
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1334 AND SER-1338, ANDMASS SPECTROMETRY. | |
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-586; THR-730; THR-903AND SER-1338, AND MASS SPECTROMETRY. | |
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1340, AND MASSSPECTROMETRY. |