| UniProt ID | NCAM2_MOUSE | |
|---|---|---|
| UniProt AC | O35136 | |
| Protein Name | Neural cell adhesion molecule 2 | |
| Gene Name | Ncam2 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 837 | |
| Subcellular Localization |
Isoform Long: Cell membrane Single-pass type I membrane protein. Isoform Short: Cell membrane Lipid-anchor, GPI-anchor. |
|
| Protein Description | May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.. | |
| Protein Sequence | MSLLLSFYLLGLLVRSGQALLQVTISLSKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVMLQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTIPDNRFAVLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAIMMPQKSFNATAERGEEMTLTCKASGSPDPTISWFRNGKLIEENEKYILKGSNTELTVRNIINKDGGSYVCKATNKAGEDQKQAFLQVFVQPHILQLKNETTSENGHVTLVCEAEGEPVPEITWKRAIDGVMFSEGDKSPDGRIEVKGQHGRSSLHIRDVKLSDSGRYDCEAASRIGGHQRSMHLDIEYAPKFVSNQTMYYSWEGNPINISCDVTANPPASIHWRREKLLLPAKNTTHLKTHSVGRKMILEIAPTSDNDFGRYNCTATNRIGTRFQEYILELADVPSSPHGVKIIELSQTTAKISFNKPESHGGVPIHHYQVDVKEVASETWKIVRSHGVQTMVVLSSLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIHGQPSSGKSFKISITKQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHIILEHLQWTMGYEVQITAANRLGYSEPTVYEFSMPPKPNIIKDTLFNGLGLGAIIGLGVAALLLILVVTDVSCFFIRQCGLLMCITRRMCGKKSGSSGKSKELEEGKAAYLKDGSKEPIVEMRTEDERITNHEDGSPVNEPNETTPLTEPEKLPLKEENGKEVLNAETIEIKVSNDIIQSKEDDIKA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 50 | Phosphorylation | TAIGEPESIDWYNPQ EECCCCCCCCCCCCC | 36.24 | 22871156 | |
| 63 | Phosphorylation | PQGEKIISTQRVMLQ CCCCEEEEEEEEEEH | 23.20 | 30482847 | |
| 64 | Phosphorylation | QGEKIISTQRVMLQK CCCEEEEEEEEEEHH | 15.24 | 22871156 | |
| 177 | N-linked_Glycosylation | NLQILNINKSDEGIY CEEEEECCCCCCCEE | 36.38 | - | |
| 217 | Phosphorylation | AIMMPQKSFNATAER HHCCCCCCCCCCCCC | 20.63 | - | |
| 219 | N-linked_Glycosylation | MMPQKSFNATAERGE CCCCCCCCCCCCCCC | 43.39 | - | |
| 221 | Phosphorylation | PQKSFNATAERGEEM CCCCCCCCCCCCCCE | 30.10 | - | |
| 284 | Phosphorylation | GSYVCKATNKAGEDQ CEEEEEEECCCCHHH | 23.81 | 22817900 | |
| 309 | N-linked_Glycosylation | PHILQLKNETTSENG CEEEEEECCEECCCC | 61.51 | - | |
| 406 | N-linked_Glycosylation | YAPKFVSNQTMYYSW ECCHHCCCCEEEEEE | 35.72 | - | |
| 419 | N-linked_Glycosylation | SWEGNPINISCDVTA EECCCEEEEEEEECC | 22.75 | - | |
| 445 | N-linked_Glycosylation | KLLLPAKNTTHLKTH ECCCCCCCCCCCEEC | 52.93 | - | |
| 474 | N-linked_Glycosylation | DNDFGRYNCTATNRI CCCCCCCCCCCCCCC | 18.46 | - | |
| 547 | Phosphorylation | ETWKIVRSHGVQTMV HHHHHHHHCCCEEEE | 17.44 | - | |
| 562 | N-linked_Glycosylation | VLSSLEPNTTYEIRV EEECCCCCCEEEEEE | 35.36 | - | |
| 612 | Phosphorylation | SGKSFKISITKQDDG CCCCEEEEEEECCCC | 25.46 | 24719451 | |
| 703 (in isoform 2) | GPI-anchor | - | 8.68 | - | |
| 757 | Ubiquitination | SKELEEGKAAYLKDG CCCHHCCCEEEECCC | 32.88 | 22790023 | |
| 760 | Phosphorylation | LEEGKAAYLKDGSKE HHCCCEEEECCCCCC | 21.10 | 29899451 | |
| 765 | Phosphorylation | AAYLKDGSKEPIVEM EEEECCCCCCCCEEE | 43.93 | 25521595 | |
| 774 | Phosphorylation | EPIVEMRTEDERITN CCCEEEECCCCCCCC | 46.61 | 25521595 | |
| 780 | Phosphorylation | RTEDERITNHEDGSP ECCCCCCCCCCCCCC | 36.42 | 25521595 | |
| 786 | Phosphorylation | ITNHEDGSPVNEPNE CCCCCCCCCCCCCCC | 37.69 | 25521595 | |
| 794 | Phosphorylation | PVNEPNETTPLTEPE CCCCCCCCCCCCCCC | 40.11 | 25521595 | |
| 795 | Phosphorylation | VNEPNETTPLTEPEK CCCCCCCCCCCCCCC | 15.32 | 25521595 | |
| 831 | Ubiquitination | SNDIIQSKEDDIKA- ECHHHHCCHHHCCC- | 49.11 | 22790023 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NCAM2_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NCAM2_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NCAM2_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of NCAM2_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-780, AND MASSSPECTROMETRY. | |
