ANK3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANK3_MOUSE
• UniProt AC: G5E8K5
• Protein Name: Ankyrin-3
• Gene Name: Ank3
• Organism: Mus musculus (Mouse).
• Sequence Length: 1961
• Subcellular Localization: Cytoplasm, cytoskeleton. Cell projection, axon. Cell membrane, sarcolemma. Cell junction, synapse, postsynaptic cell membrane. Lysosome. In skeletal muscle, localized at costameres and neuromuscular junctions. In bone marrow-derived macrophages, isof
• Protein Description: Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (By similarity). In skeletal muscle, required for costamere localization of DMD and betaDAG1. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption. [PubMed: 23903368]
• Protein Sequence: MSEEPKEKPAKPAHRKRKGKKSDANASYLRAARAGHLEKALDYIKNGVDVNICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVRFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDTNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRSAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKASPNAKALNGFTPLHIACKKNRIRVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLAAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVASLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATSLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLSRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTALHQAAQQGHTHIINVLLQNNASPNELTVNGNTALAIARRLGYISVVDTLKVVTEEIMTTTTITEKHKMNVPETMNEVLDMSDDEVRKASAPEKLSDGEYISDGEEGDKCTWFKIPKVQEVLVKSEDAITGDTDKYLGPQDLKELGDDSLPAEGYVGFSLGARSASLRSFSSDRSYTLNRSSYARDSMMIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPVHSGFLVSFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQFLGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLAELLNGMDEELDSPEELGTKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIRVGLQAQPVPEETVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKGDATPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLASQLYRELICVPYMAKFVVFAKTNDPVESSLRCFCMTDDRVDKTLEQQENFEEVARSKDIEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFLKEPKTTKGLPQTAVCNLNITLPAHKKAEKADRRQSFASLALRKRYSYLTEPSMSPQSPCERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALTSVLTKINRIDIVTLLEGPIFDYGNISGTRSFADENNVFHDPVDGHPSFQVELETPMGLYCTPPNPFQQDDHFSDISSIESPFRTPSRLSDGLVPSQGNIEHPTGGPPVVTAEDTSLEDSKMDDSVTVTDPADPLDVDESQLKDLCQSECAQCWASVPGIPNDGRQAEPLRPQTRKVGMSSEQQEKGKSGPDEEVTEDKVKSLFEDIQLEEVEAEEMTEDQGQAMLNRVQRAELAMSSLAGWQNETPSGSLESPAQARRLTGGLLDRLDDSSDQARDSITSYLTGEPGKIEANGNHTAEVIPEAKAKPYFPESQNDIGKQSIKENLKPKTHGCGRTEEPVSPLTAYQKSLEETSKLVIEDAPKPCVPVGMKKMTRTTADGKARLNLQEEEGSTRSEPKQGEGYKVKTKKEIRNVEKKTH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSEEPKEKP ------CCCCCCCCC		29514104
22	Phosphorylation	RKRKGKKSDANASYL HCCCCCCCHHCHHHH		26824392
27	Phosphorylation	KKSDANASYLRAARA CCCHHCHHHHHHHHH		50351319
28	Phosphorylation	KSDANASYLRAARAG CCHHCHHHHHHHHHH		25777480
39	Ubiquitination	ARAGHLEKALDYIKN HHHHCHHHHHHHHHC		22790023
43	Phosphorylation	HLEKALDYIKNGVDV CHHHHHHHHHCCCCE		29514104
228	Phosphorylation	PLHIAAHYGNINVAT CHHHHHHHCCCCHHH		29514104
247	Phosphorylation	RAAAVDFTARNDITP HHHHCCCCCCCCCCC		22807455
260	Ubiquitination	TPLHVASKRGNANMV CCCHHHCCCCCCCHH		22790023
268	Ubiquitination	RGNANMVKLLLDRGA CCCCCHHHHHHHCCC		-
367	Ubiquitination	CGHYKVAKVLLDKKA CCCHHHHHHHHCCCC		-
385	Phosphorylation	AKALNGFTPLHIACK CHHHCCCCHHHHHHH		25367039
392	Ubiquitination	TPLHIACKKNRIRVM CHHHHHHHCCHHHHH		-
484	Phosphorylation	AKAKDDQTPLHISAR EECCCCCCCHHHHHC		45564093
507	Phosphorylation	QLLQQGASPNAATTS HHHHCCCCCCCCCCC		30458943
557	Ubiquitination	TPLHVAAKYGKLEVA CHHHHHHHHCCHHHH		-
606	Phosphorylation	LLLDQGASPHAAAKN EEECCCCCHHHHHHC		22324799
623	Ubiquitination	TPLHIAAKKNQMDIA CHHHHHHHHCCCHHH		-
727 (in isoform 6)	Phosphorylation	-		25338131
729 (in isoform 6)	Phosphorylation	-		25338131
732 (in isoform 6)	Phosphorylation	-		30352176
736	Phosphorylation	VNFLLQHSAKVNAKT HHHHHHHCCCCCCCC		29899451
791	Phosphorylation	AIARRLGYISVVDTL HHHHHHCCEEEEEHH		29899451
793	Phosphorylation	ARRLGYISVVDTLKV HHHHCCEEEEEHHHH		55443769
822	Phosphorylation	HKMNVPETMNEVLDM HCCCCCHHHHHHHCC		21183079
822 (in isoform 2)	Phosphorylation	-		29899451
822 (in isoform 3)	Phosphorylation	-		29899451
830	Phosphorylation	MNEVLDMSDDEVRKA HHHHHCCCHHHHHHC		26239621
830 (in isoform 2)	Phosphorylation	-		30352176
830 (in isoform 3)	Phosphorylation	-		30352176
838	Phosphorylation	DDEVRKASAPEKLSD HHHHHHCCCCCCCCC		29514104
844	Phosphorylation	ASAPEKLSDGEYISD CCCCCCCCCCCCCCC		26239621
845 (in isoform 2)	Phosphorylation	-		22807455
845 (in isoform 3)	Phosphorylation	-		22807455
848	Phosphorylation	EKLSDGEYISDGEEG CCCCCCCCCCCCCCC		-
850	Phosphorylation	LSDGEYISDGEEGDK CCCCCCCCCCCCCCC		26239621
852	Phosphorylation	DGEYISDGEEGDKCT CCCCCCCCCCCCCCE		-
863	Phosphorylation	DKCTWFKIPKVQEVL CCCEEEECCCCEEEE		-
873	Phosphorylation	VQEVLVKSEDAITGD CEEEEECCHHHCCCC		21183079
881	Phosphorylation	EDAITGDTDKYLGPQ HHHCCCCCCCCCCHH		-
884	Phosphorylation	ITGDTDKYLGPQDLK CCCCCCCCCCHHHHH		29514104
897	Phosphorylation	LKELGDDSLPAEGYV HHHHCCCCCCCCCCC		41301663
912	Phosphorylation	GFSLGARSASLRSFS EEECCCCCCCCCCCC		21743459
914	Phosphorylation	SLGARSASLRSFSSD ECCCCCCCCCCCCCC		30352176
917	Phosphorylation	ARSASLRSFSSDRSY CCCCCCCCCCCCCCE		30352176
919	Phosphorylation	SASLRSFSSDRSYTL CCCCCCCCCCCCEEE		23737553
920	Phosphorylation	ASLRSFSSDRSYTLN CCCCCCCCCCCEEEC		23737553
923	Phosphorylation	RSFSSDRSYTLNRSS CCCCCCCCEEECCCH		21183079
924	Phosphorylation	SFSSDRSYTLNRSSY CCCCCCCEEECCCHH		29514104
925	Phosphorylation	FSSDRSYTLNRSSYA CCCCCCEEECCCHHC		29514104
929	Phosphorylation	RSYTLNRSSYARDSM CCEEECCCHHCCHHC		29514104
930	Phosphorylation	SYTLNRSSYARDSMM CEEECCCHHCCHHCC		29514104
931	Phosphorylation	YTLNRSSYARDSMMI EEECCCHHCCHHCCE		21183079
935	Phosphorylation	RSSYARDSMMIEELL CCHHCCHHCCEEEHH		21183079
946	Ubiquitination	EELLVPSKEQHLTFT EEHHCCCHHHCCEEE		22790023
958	Phosphorylation	TFTREFDSDSLRHYS EEEEECCCCCCHHCC		22324799
960	Phosphorylation	TREFDSDSLRHYSWA EEECCCCCCHHCCEE		27087446
970	Phosphorylation	HYSWAADTLDNVNLV HCCEEHHCCCCEEEC		21183079
978	Phosphorylation	LDNVNLVSSPVHSGF CCCEEECCCCCCCCE		21183079
979	Phosphorylation	DNVNLVSSPVHSGFL CCEEECCCCCCCCEE		21183079
1030	Ubiquitination	CRLVKRHKLANPPPM HHHHHHHCCCCCCCC		22790023
1114	Phosphorylation	GMDEELDSPEELGTK CCCHHCCCHHHHCCH		18056256
1120	Phosphorylation	DSPEELGTKRICRII CCHHHHCCHHHHHHH		22807455
1174	Ubiquitination	FPEGALTKRIRVGLQ CCCCCCCCCEEEEEE		22790023
1197	Ubiquitination	VKKILGNKATFSPIV HHHHHCCCCCCCCCE		22790023
1227	Phosphorylation	TIPVPPPSGEGVSNG EEECCCCCCCCCCCC		29514104
1232	Phosphorylation	PPSGEGVSNGYKGDA CCCCCCCCCCCCCCC		29514104
1235	Phosphorylation	GEGVSNGYKGDATPN CCCCCCCCCCCCCCC		29514104
1405	Phosphorylation	FSIKIRDTSQEPCGR EEEEEECCCCCCCCC		29899451
1406	Phosphorylation	SIKIRDTSQEPCGRL EEEEECCCCCCCCCE		29899451
1451	Phosphorylation	EKADRRQSFASLALR HHCHHHHHHHHHHHH		26824392
1454	Phosphorylation	DRRQSFASLALRKRY HHHHHHHHHHHHHHH		26160508
1461	Phosphorylation	SLALRKRYSYLTEPS HHHHHHHHHHHCCCC		26239621
1462	Phosphorylation	LALRKRYSYLTEPSM HHHHHHHHHHCCCCC		26239621
1463	Phosphorylation	ALRKRYSYLTEPSMS HHHHHHHHHCCCCCC		26239621
1465	Phosphorylation	RKRYSYLTEPSMSPQ HHHHHHHCCCCCCCC		26239621
1468	Phosphorylation	YSYLTEPSMSPQSPC HHHHCCCCCCCCCCC		28066266
1470	Phosphorylation	YLTEPSMSPQSPCER HHCCCCCCCCCCCCC		26239621
1473	Phosphorylation	EPSMSPQSPCERTDI CCCCCCCCCCCCCCH		27087446
1520	O-linked_Glycosylation	ENPNSLISQSFMLLK CCCCCHHHHHHHHHH		19458039
1555 (in isoform 2)	Phosphorylation	-		25338131
1557 (in isoform 2)	Phosphorylation	-		25338131
1560 (in isoform 2)	Phosphorylation	-		30352176
1569	Phosphorylation	IFDYGNISGTRSFAD CCCCCCCCCCCCCCC		101546053
1599	Phosphorylation	QVELETPMGLYCTPP EEEEECCCEEEECCC		-
1627	Phosphorylation	SIESPFRTPSRLSDG HCCCCCCCCCCCCCC		29472430
1629	Phosphorylation	ESPFRTPSRLSDGLV CCCCCCCCCCCCCCC		29472430
1632	Phosphorylation	FRTPSRLSDGLVPSQ CCCCCCCCCCCCCCC		28464351
1638	Phosphorylation	LSDGLVPSQGNIEHP CCCCCCCCCCCCCCC		29472430
1646	Phosphorylation	QGNIEHPTGGPPVVT CCCCCCCCCCCCEEE		29472430
1657	Phosphorylation	PVVTAEDTSLEDSKM CEEECCCCCCCCCCC		30352176
1658	Phosphorylation	VVTAEDTSLEDSKMD EEECCCCCCCCCCCC		30352176
1779	Phosphorylation	QRAELAMSSLAGWQN HHHHHHHHHHCCCCC		22324799
1780	Phosphorylation	RAELAMSSLAGWQNE HHHHHHHHHCCCCCC		22324799
1788	Phosphorylation	LAGWQNETPSGSLES HCCCCCCCCCCCCCC		22324799
1790	Phosphorylation	GWQNETPSGSLESPA CCCCCCCCCCCCCHH		22324799
1792	Phosphorylation	QNETPSGSLESPAQA CCCCCCCCCCCHHHH		24759943
1795	Phosphorylation	TPSGSLESPAQARRL CCCCCCCCHHHHHHH		22324799
1803	Phosphorylation	PAQARRLTGGLLDRL HHHHHHHHHCHHHHC		28973931
1813	Phosphorylation	LLDRLDDSSDQARDS HHHHCCCCCHHHHHH		28464351
1814	Phosphorylation	LDRLDDSSDQARDSI HHHCCCCCHHHHHHH		28464351
1851	Phosphorylation	PEAKAKPYFPESQND CHHHCCCCCCCCCCC		29514104
1855	Phosphorylation	AKPYFPESQNDIGKQ CCCCCCCCCCCCCHH		29899451
1863	Phosphorylation	QNDIGKQSIKENLKP CCCCCHHHHHHHCCC		25338131
1872	Phosphorylation	KENLKPKTHGCGRTE HHHCCCCCCCCCCCC		29899451
1883	Phosphorylation	GRTEEPVSPLTAYQK CCCCCCCCHHHHHHH		26824392
1886	Phosphorylation	EEPVSPLTAYQKSLE CCCCCHHHHHHHHHH		25619855
1888	Phosphorylation	PVSPLTAYQKSLEET CCCHHHHHHHHHHHH		29514104
1891	Phosphorylation	PLTAYQKSLEETSKL HHHHHHHHHHHHHCC		27357545
1895	Phosphorylation	YQKSLEETSKLVIED HHHHHHHHHCCEECC		27357545
1935	Phosphorylation	LQEEEGSTRSEPKQG CCCCCCCCCCCCCCC		41301655
1937	Phosphorylation	EEEGSTRSEPKQGEG CCCCCCCCCCCCCCC		41301659

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANK3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANK3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANK3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HOOK1_MOUSE	Hook1	physical	15823567

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.