HOOK1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HOOK1_MOUSE
• UniProt AC: Q8BIL5
• Protein Name: Protein Hook homolog 1
• Gene Name: Hook1
• Organism: Mus musculus (Mouse).
• Sequence Length: 728
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton . Localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, multivesicular bodies (MVBs), lysosomes, or mitochondria (PubMed:12075009). Often fou
• Protein Description: Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton. [PubMed: 12075009 Component of the FTS/Hook/FHIP complex (FHF complex The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (By similarity]
• Protein Sequence: MEDPQPLPQSELPLCDSLIIWLQTFKTASPCQDVKQLTNGVTMAQVLHQIDVAWFSESWLSRIKDDVGDNWRIKASNLKKVLHGITSYYHEFLGQQISEELIPDLNQITECADPVELGRLLQLILGCAVNCEKKQEHIKNIMTLEESVQHVVMTAIQELMSKEIVISPASDTVGELEQQLKRALEELQEAIAEKEELKQRCQELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTMVAKKYFHVQLQLEQLQEENYRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKLESTVEVYRQKLQDLNDLRKQVKSLQETNMMYMHNTVSLEEELKKANAARAQLETYKRQVQDLHTKLSSESKRADTLAFEMKRLEEKHETLLKEKERLIEQRDTLKETNEELRCSKAQQDHLNQADASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGTENERIEQLQEQLEQKHRKMNELETEQRLSKERIGELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDISQNAQKISELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESECKVAKLRDYEEKLIVSAWYNKSLAFQKLGMESRLVSGASACKDSVAAAPARSFLAQQRHITNTRRNLSVKVPAAASD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEDPQPLP -------CCCCCCCC	13.71	-
167	Phosphorylation	MSKEIVISPASDTVG HHCCCEECCCCCHHH	11.97	26745281
170	Phosphorylation	EIVISPASDTVGELE CCEECCCCCHHHHHH	36.88	26745281
172	Phosphorylation	VISPASDTVGELEQQ EECCCCCHHHHHHHH	28.10	26745281
235	Phosphorylation	KLDQLDGSFDDPNTM HHHHCCCCCCCCCHH	25.76	22817900
293	Phosphorylation	QHRNDELTSLAEETR HHCCHHHHHHHHHHH	21.46	30635358
294	Phosphorylation	HRNDELTSLAEETRA HCCHHHHHHHHHHHH	37.90	30635358
322	Phosphorylation	KANKLESTVEVYRQK HHHHHHHHHHHHHHH	16.00	24719451
326	Phosphorylation	LESTVEVYRQKLQDL HHHHHHHHHHHHHHH	8.20	24719451
450	Phosphorylation	ADASATKSYENLAAE HCHHHCHHHHHHHHH	33.07	26643407
451	Phosphorylation	DASATKSYENLAAEI CHHHCHHHHHHHHHH	15.47	28066266
607	Acetylation	KAMEERYKMYLEKAR HHHHHHHHHHHHHHH	27.56	6568957
636	Acetylation	AEIMLLRKQLAEKER HHHHHHHHHHHHHHH	50.02	8277289
641	Acetylation	LRKQLAEKERRIEIL HHHHHHHHHHHHHHH	51.41	8277299
678	Ubiquitination	NKSLAFQKLGMESRL CHHHHHHHHCCCHHH	40.32	-
690	Phosphorylation	SRLVSGASACKDSVA HHHCCCHHHCCHHHH	37.41	26824392
693	Ubiquitination	VSGASACKDSVAAAP CCCHHHCCHHHHHHH	53.40	-
719	Phosphorylation	TNTRRNLSVKVPAAA CCCCCCEEEECCCCC	24.36	26239621
727	Phosphorylation	VKVPAAASD------ EECCCCCCC------	38.84	12075009

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HOOK1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HOOK1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HOOK1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANK3_MOUSE	Ank3	physical	15823567
VPS18_MOUSE	Vps18	physical	14668490

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.