VPS18_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VPS18_MOUSE
• UniProt AC: Q8R307
• Protein Name: Vacuolar protein sorting-associated protein 18 homolog
• Gene Name: Vps18
• Organism: Mus musculus (Mouse).
• Sequence Length: 973
• Subcellular Localization: Late endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Early endosome . Cytoplasmic vesicle, autophagosome . Cytoplasmic vesicle, clathrin-coated vesicle . Cytopl
• Protein Description: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (By similarity). Required for fusion of endosomes and autophagosomes with lysosomes. [PubMed: 14517315]
• Protein Sequence: MASILDEYEDSLSRSAVLQTGCPSVGIPHSGYVSAHLEKEVPIFTKQRVDFTPSERITSLVVSCNQLCMSLGKDTLLRIDLGKASEPNRVELGRKDDAKVHKMFLDHTGSHLLVALSSTEVLYMNRNGQKARPLARWKGQLVESVGWNKAMGNESSTGPILVGTAQGQIFEAELSASEGGLFGPAPDLYFRPLYVLNEEGGPAPVCSLEAERGPDGRGFVIATTRQRLFQFIGRAVEDTEAQGFAGLFAAYTDHPPPFREFPSNLGYSELAFYTPKLRSAPRAFAWMMGDGVLYGSLDCGRPDSLLSEERVWEYPAGVGPGANPPLAIVLTQFHFLLLLADRVEAVCTLTGQVVLRDHFLEKFGPLRHMVKDSSTGHLWAYTERAVFRYHVQREARDVWRTYLDMNRFDLAKEYCRERPDCLDTVLAREADFCFRQHRYLESARCYALTQSYFEEIALKFLEARQEEALAEFLQRKLAGLKPTERTQATLLTTWLTELYLSRLGALQGDPDALTLYRDTRECFRTFLSSPRHKEWLFASRASIHELLASHGDTEHMVYFAVIMQDYERVVAYHCQHEAYEEALAVLARHRDPQLFYKFSPILIRHIPRQLVDAWIEMGSRLDARQLIPALVNYSQGGEAQQVSQAIRYMEFCVNVLGETEQAIHNYLLSLYARGQPASLLAYLEQAGASPHRVHYDLKYALRLCAEHGHHRACVHVYKVLELYEEAVDLALQVDVDLAKQCADLPEEDEELRKKLWLKIARHVVQEEEDVQTAMACLASCPLLKIEDVLPFFPDFVTIDHFKEAICSSLKAYNHHIQELQREMEEATASAQRIRRDLQELRGRYGTVEPQDKCSTCDFPLLNRPFYLFLCGHMFHADCLLQAVRPGLPAYKQARLEELQRKLGAAPPPTKGSVKAKEAEAGAAAVGPSREQLKADLDELVAAECVYCGELMIRSIDRPFIDPQRYEEEHLSWL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASILDEYE ------CCCHHHHHH	12.79	-
3	Phosphorylation	-----MASILDEYED -----CCCHHHHHHH	23.53	25293948
11	Phosphorylation	ILDEYEDSLSRSAVL HHHHHHHHHCHHHHH	19.12	28973931
13	Phosphorylation	DEYEDSLSRSAVLQT HHHHHHHCHHHHHHH	28.30	30482847
15	Phosphorylation	YEDSLSRSAVLQTGC HHHHHCHHHHHHHCC	21.25	-
32	Phosphorylation	VGIPHSGYVSAHLEK CCCCCCCCCCEEEEC	8.34	29514104
108	Phosphorylation	HKMFLDHTGSHLLVA HHHHHHCCCCCEEEE	39.79	25777480
110	Phosphorylation	MFLDHTGSHLLVALS HHHHCCCCCEEEEEC	16.47	25777480
117	Phosphorylation	SHLLVALSSTEVLYM CCEEEEECCCEEEEE	26.02	25777480
118	Phosphorylation	HLLVALSSTEVLYMN CEEEEECCCEEEEEC	29.45	25777480
119	Phosphorylation	LLVALSSTEVLYMNR EEEEECCCEEEEECC	27.08	25777480
123	Phosphorylation	LSSTEVLYMNRNGQK ECCCEEEEECCCCCC	9.49	25777480
362	Acetylation	LRDHFLEKFGPLRHM ECHHHHHHHCCCCHH	58.74	-
682	Phosphorylation	QPASLLAYLEQAGAS CCHHHHHHHHHCCCC	15.67	29899451
689	Phosphorylation	YLEQAGASPHRVHYD HHHHCCCCCCCCCCC	21.96	22817900
695	Phosphorylation	ASPHRVHYDLKYALR CCCCCCCCCHHHHHH	21.80	29899451
758	Ubiquitination	LRKKLWLKIARHVVQ HHHHHHHHHHHHHHC	23.80	-
810	Ubiquitination	EAICSSLKAYNHHIQ HHHHHHHHHHHHHHH	51.26	-
909	Phosphorylation	LGAAPPPTKGSVKAK HCCCCCCCCCCHHHH	54.53	25338131
910	Ubiquitination	GAAPPPTKGSVKAKE CCCCCCCCCCHHHHH	55.77	27667366
912	Phosphorylation	APPPTKGSVKAKEAE CCCCCCCCHHHHHHH	23.23	25266776
916	Ubiquitination	TKGSVKAKEAEAGAA CCCCHHHHHHHHHCC	52.30	27667366
928	Phosphorylation	GAAAVGPSREQLKAD HCCCCCCCHHHHHCC	42.39	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VPS18_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VPS18_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VPS18_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPE39_HUMAN	VIPAS39	physical	19109425
VP33B_HUMAN	VPS33B	physical	19109425
STX1A_MOUSE	Stx1a	physical	14623309
STX6_MOUSE	Stx6	physical	14623309
STX8_MOUSE	Stx8	physical	14623309
VPS45_MOUSE	Vps45	physical	14623309
HOOK1_MOUSE	Hook1	physical	14668490
VPS41_MOUSE	Vps41	physical	14668490
VPS39_MOUSE	Vps39	physical	14668490
VPS45_MOUSE	Vps45	physical	14668490
STX6_MOUSE	Stx6	physical	14668490
STX12_MOUSE	Stx12	physical	14668490
VAMP8_MOUSE	Vamp8	physical	14668490

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.