VPS45_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VPS45_MOUSE
• UniProt AC: P97390
• Protein Name: Vacuolar protein sorting-associated protein 45
• Gene Name: Vps45
• Organism: Mus musculus (Mouse).
• Sequence Length: 570
• Subcellular Localization: Golgi apparatus membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Associated with Golgi/endosomal vesicles and the trans-Golgi network.
• Protein Description: May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network..
• Protein Sequence: MNVVFAVKQYISKMIEDSGPGMKVLLMDKETTGIVSMVYTQSEILQKEVYLFERIDSQNREIMKHLKAICFLRPTKENVEYLIQELRRPKYSIYFIYFSNVISKSDVKSLAEADEQEVVAEVQEFYGDYIAVNPHLFSLNILGCCQGRNWDPAQLSRTTQGLTALLLSLKKCPMIRYQLSSEAAKRLGECVKQVISKEYELFEFRRTEVPPLLLILDRCDDAITPLLNQWTYQAMVHELLGINNNRIDLSRVPGISKDLREVVLSAENDEFYANNMYLNFAEIGSNIKNLMEDFQKKRPKEQQKLESIADMKAFVENYPQFKKMSGTVSKHVTVVGELSRLVSERNLLEVSEVEQELACQNDHSSALQNVKRLLQNPKVTEFDAVRLVMLYALHYERHSSNSLPGLIVDLRSKGVAEKYRKLVSAVVEYGGKRVRGSDLFSPKDAVAITKQFLKGLKGVENVYTQHQPFLHETLDHLIKGRLKENLYPYLGPSTLRDRPQDIIVFIIGGATYEEALTVYNLNRTTPGVRIVLGGTTIHNTKSFLEEVLASGLHSRSRESSQATSRSANRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	ISKMIEDSGPGMKVL HHHHHHHCCCCCEEE	33.81	29233185
23	Ubiquitination	EDSGPGMKVLLMDKE HHCCCCCEEEEECCC	35.33	22790023
31	Phosphorylation	VLLMDKETTGIVSMV EEEECCCCCCEEEEE	35.74	21659604
32	Phosphorylation	LLMDKETTGIVSMVY EEECCCCCCEEEEEE	26.46	21659604
42	Phosphorylation	VSMVYTQSEILQKEV EEEEEEHHHHHHHHH	20.85	21659604
57	Phosphorylation	YLFERIDSQNREIMK HHHHHCHHCCHHHHH	27.30	-
172	S-nitrosylation	LLLSLKKCPMIRYQL HHHHHCCCCCHHHHC	2.36	21278135
172	S-nitrosocysteine	LLLSLKKCPMIRYQL HHHHHCCCCCHHHHC	2.36	-
192	Ubiquitination	KRLGECVKQVISKEY HHHHHHHHHHHHHCH	50.97	22790023
257	Ubiquitination	SRVPGISKDLREVVL HHCCCCCHHHHHHHH	59.88	22790023
307	Phosphorylation	KEQQKLESIADMKAF HHHHHHHHHHHHHHH	33.25	30352176
318	Phosphorylation	MKAFVENYPQFKKMS HHHHHHHCHHHHHCC	5.72	29514104
412	Phosphorylation	GLIVDLRSKGVAEKY CEEEECHHCCHHHHH	40.85	28609623
418	Acetylation	RSKGVAEKYRKLVSA HHCCHHHHHHHHHHH	40.39	6571547
418	Malonylation	RSKGVAEKYRKLVSA HHCCHHHHHHHHHHH	40.39	26320211
421	Malonylation	GVAEKYRKLVSAVVE CHHHHHHHHHHHHHH	50.58	32601280
432	Acetylation	AVVEYGGKRVRGSDL HHHHCCCEECCCCCC	43.27	7713979
441	Phosphorylation	VRGSDLFSPKDAVAI CCCCCCCCHHHHHHH	38.03	22324799
443	Ubiquitination	GSDLFSPKDAVAITK CCCCCCHHHHHHHHH	58.06	27667366
450	Ubiquitination	KDAVAITKQFLKGLK HHHHHHHHHHHHHCC	32.70	22790023
454	Ubiquitination	AITKQFLKGLKGVEN HHHHHHHHHCCCCCC	64.58	27667366
483	Ubiquitination	HLIKGRLKENLYPYL HHHHCHHHHCCCCCC	43.10	22790023
487	Phosphorylation	GRLKENLYPYLGPST CHHHHCCCCCCCHHH	11.04	21082442
493	Phosphorylation	LYPYLGPSTLRDRPQ CCCCCCHHHCCCCCC	37.97	21082442
494	Phosphorylation	YPYLGPSTLRDRPQD CCCCCHHHCCCCCCC	29.01	21082442
556	Phosphorylation	ASGLHSRSRESSQAT HCCCHHCCHHHHHCH	43.33	23684622
559	Phosphorylation	LHSRSRESSQATSRS CHHCCHHHHHCHHHH	27.00	23684622

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VPS45_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VPS45_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VPS45_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of VPS45_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.