STX8_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STX8_MOUSE
• UniProt AC: O88983
• Protein Name: Syntaxin-8
• Gene Name: Stx8
• Organism: Mus musculus (Mouse).
• Sequence Length: 236
• Subcellular Localization: Membrane; Single-pass type IV membrane protein. Preferentially associated with the early endosome. To a lesser extent, also present in late endosome, the plasma membrane and coated pits (By similarity)..
• Protein Description: Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER..
• Protein Sequence: MAPDPWFSTYDSTCQIAQEIAEKIQERNQCERRGEKTPKLTLTIRTLLKNLKVKIDLLKDLLLRAVSTRQITQLEGDRRQNLLDDLVTRERLLLASFKNEGAEPDLIRSSLMSEEAKRGTPNPWLCEEPEETRGLGFDEIRQQQQKIIQEQDAGLDALSSIISRQKQMGQEIGNELDEQNEIIDDLANLVENTDEKLRTEARRVTLVDRKSTSCGMIMVILLLLVAIVVVAVWPTN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	S-palmitoylation	FSTYDSTCQIAQEIA CCCCHHHHHHHHHHH	2.97	28680068
14	Glutathionylation	FSTYDSTCQIAQEIA CCCCHHHHHHHHHHH	2.97	24333276
41	Phosphorylation	GEKTPKLTLTIRTLL CCCCCCHHHHHHHHH	28.16	29472430
43	Phosphorylation	KTPKLTLTIRTLLKN CCCCHHHHHHHHHHH	11.81	29472430
52	Acetylation	RTLLKNLKVKIDLLK HHHHHHCCHHHHHHH	51.37	19850831
59	Ubiquitination	KVKIDLLKDLLLRAV CHHHHHHHHHHHHHH	54.34	22790023
59	Acetylation	KVKIDLLKDLLLRAV CHHHHHHHHHHHHHH	54.34	19850839
96	Phosphorylation	RERLLLASFKNEGAE HHHHHHHHHCCCCCC	36.40	26824392
98	Ubiquitination	RLLLASFKNEGAEPD HHHHHHHCCCCCCHH	52.15	22790023
109	Phosphorylation	AEPDLIRSSLMSEEA CCHHHHHHHHCCHHH	22.34	25338131
117	Ubiquitination	SLMSEEAKRGTPNPW HHCCHHHHCCCCCCC	55.42	27667366
120	Phosphorylation	SEEAKRGTPNPWLCE CHHHHCCCCCCCCCC	24.75	22817900
122	Ubiquitination	EAKRGTPNPWLCEEP HHHCCCCCCCCCCCC	39.97	27667366
146	Ubiquitination	EIRQQQQKIIQEQDA HHHHHHHHHHHHHHH	37.12	22790023
159	Phosphorylation	DAGLDALSSIISRQK HHHHHHHHHHHHHHH	22.63	26745281
160	Phosphorylation	AGLDALSSIISRQKQ HHHHHHHHHHHHHHH	25.45	19144319
163	Phosphorylation	DALSSIISRQKQMGQ HHHHHHHHHHHHHHH	27.30	19144319

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Hectd3	Q3U487	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STX8_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STX8_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of STX8_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.