STX12_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STX12_MOUSE
• UniProt AC: Q9ER00
• Protein Name: Syntaxin-12
• Gene Name: Stx12
• Organism: Mus musculus (Mouse).
• Sequence Length: 274
• Subcellular Localization: Endosome membrane; Single-pass type IV membrane protein . Golgi apparatus membrane; Single-pass type IV membrane protein . Endomembrane system ; Single-pass type IV membrane protein ; Cytoplasmic side . Early endosome membrane ; Single-pass type IV membra
• Protein Description: SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity)..
• Protein Sequence: MSYGPLDMYRNPGPSGPQPRDFNSIIQTCSGNIQRISQATAQIKNLMSQLGTKQDSSKLQENLQQLQHSTNQLAKETNELLKELGSLPLPLSASEQRQQKLQKERLMNDFSSALNNFQVVQRKVSEKEKESIARARAGSRLSAEDRQREEQLVSFDSHEEWNQMQSQEEEAAITEQDLELIKERETAIRQLEADILDVNQIFKDLAMMIHDQGDLIDSIEANVESSEVHVERATDQLQRAAYYQKKSRKKMCILVLVLSVIVTVLVVVIWVASK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSYGPLDMY ------CCCCCCCCC	38.50	-
2	Phosphorylation	------MSYGPLDMY ------CCCCCCCCC	38.50	26239621
3	Phosphorylation	-----MSYGPLDMYR -----CCCCCCCCCC	22.82	28066266
9	Phosphorylation	SYGPLDMYRNPGPSG CCCCCCCCCCCCCCC	13.60	29514104
15	Phosphorylation	MYRNPGPSGPQPRDF CCCCCCCCCCCCCCH	69.85	26239621
44	Ubiquitination	SQATAQIKNLMSQLG HHHHHHHHHHHHHHC	31.76	-
53	Ubiquitination	LMSQLGTKQDSSKLQ HHHHHCCCCCHHHHH	50.76	-
58	Ubiquitination	GTKQDSSKLQENLQQ CCCCCHHHHHHHHHH	59.13	-
82	Ubiquitination	KETNELLKELGSLPL HHHHHHHHHHCCCCC	64.61	-
92	Phosphorylation	GSLPLPLSASEQRQQ CCCCCCCCHHHHHHH	28.01	22817900
94	Phosphorylation	LPLPLSASEQRQQKL CCCCCCHHHHHHHHH	30.77	20415495
139	Phosphorylation	IARARAGSRLSAEDR HHHHHHHCCCCHHHH	29.12	26824392
142	Phosphorylation	ARAGSRLSAEDRQRE HHHHCCCCHHHHHHH	28.62	26824392
218	Phosphorylation	DQGDLIDSIEANVES CCCCHHHHHHHHCCC	18.48	19144319
225	Phosphorylation	SIEANVESSEVHVER HHHHHCCCCCHHHHH	27.76	19144319
245	Ubiquitination	QRAAYYQKKSRKKMC HHHHHHHHHCHHHHH	36.27	27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STX12_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STX12_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STX12_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of STX12_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-139; SER-142 ANDSER-218, AND MASS SPECTROMETRY.
PubMed: 19144319