SEPT3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SEPT3_MOUSE
• UniProt AC: Q9Z1S5
• Protein Name: Neuronal-specific septin-3
• Gene Name: 3-Sep
• Organism: Mus musculus (Mouse).
• Sequence Length: 350
• Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, synapse.
• Protein Description: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)..
• Protein Sequence: MSKGLPEARTDAAMSELVPEPRPKPAVPMKPVSINSNLLGYIGIDTIIEQMRKKTMKTGFDFNIMVVGQSGLGKSTLVNTLFKSQVSRKASSWNREEKIPKTVEIKAIGHVIEEGGVKMKLTVIDTPGFGDQINNENCWEPIEKYINEQYEKFLKEEVNIARKKRIPDTRVHCCLYFISPTGHSLRPLDLEFMKHLSKVVNIIPVIAKADTMTLEEKSEFKQRVRKELEVNGIEFYPQKEFDEDLEDKTENDKIRQESMPFAVVGSDKEYQVNGKRVLGRKTPWGIIEVENLNHCEFALLRDFVIRTHLQDLKEVTHNIHYETYRAKRLNDNGGLPPVSVDTEESHDSNP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Ubiquitination	GLPEARTDAAMSELV CCCHHHHHHHHHHCC	27.12	27667366
24	Ubiquitination	LVPEPRPKPAVPMKP CCCCCCCCCCCCCCC	47.06	27667366
91	Phosphorylation	SQVSRKASSWNREEK HHHHHHCCCCCCCCC	38.63	29899451
92	Phosphorylation	QVSRKASSWNREEKI HHHHHCCCCCCCCCC	32.98	29899451
98	Ubiquitination	SSWNREEKIPKTVEI CCCCCCCCCCCEEEE	60.60	22790023
101	Ubiquitination	NREEKIPKTVEIKAI CCCCCCCCEEEEEEE	69.54	22790023
118	Ubiquitination	VIEEGGVKMKLTVID EHHHCCEEEEEEEEE	33.32	22790023
142	Ubiquitination	NENCWEPIEKYINEQ CCCCCHHHHHHHHHH	4.90	27667366
155	Ubiquitination	EQYEKFLKEEVNIAR HHHHHHHHHHHHHHH	55.77	22790023
169	Phosphorylation	RKKRIPDTRVHCCLY HHCCCCCCCEEEEEE	29.27	30387612
213	Ubiquitination	IAKADTMTLEEKSEF HHCCCCCCHHHHHHH	32.86	27667366
218	Phosphorylation	TMTLEEKSEFKQRVR CCCHHHHHHHHHHHH	52.09	23737553
226	Ubiquitination	EFKQRVRKELEVNGI HHHHHHHHHHHHCCE	64.89	22790023
262	Ubiquitination	RQESMPFAVVGSDKE HHHHCCEEEECCCCE	6.82	27667366
268	Ubiquitination	FAVVGSDKEYQVNGK EEEECCCCEEEECCE	61.08	22790023
274	Ubiquitination	DKEYQVNGKRVLGRK CCEEEECCEEECCCC	21.93	27667366
275	Ubiquitination	KEYQVNGKRVLGRKT CEEEECCEEECCCCC	33.84	27667366
345	Phosphorylation	VSVDTEESHDSNP-- CCCCCCCCCCCCC--	26.77	29899451
455	Phosphorylation	---------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SEPT3_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
91	S	Phosphorylation	Phosphorylated by PKG on Ser-91 (By similarity).	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SEPT3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SEPT3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.