ANR28_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANR28_MOUSE
• UniProt AC: Q505D1
• Protein Name: Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
• Gene Name: Ankrd28
• Organism: Mus musculus (Mouse).
• Sequence Length: 1053
• Subcellular Localization: Nucleus, nucleoplasm. Seems to be excluded from nucleoli..
• Protein Description: Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation (By similarity)..
• Protein Sequence: MAFLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQILLKHSADVNARDKNWQTPLHIAAANKAVKCAESLVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGANVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYVLKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSATSVDANPAVVDNHGYTALHWACYNGHETCVELLLEQDVFQKIDGNAFSPLHCAVINDNEGAAEMLIDSLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSQNAQVNSADSTGKTPLMMAAENGQTNTVEMLVSSASADLTLQDKSKNTALHLACGKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILATMMPVSSSSPLTSLTFNAINRYTNTSKTVSFEALPIMRNEASSYCSFNNIGGEQEYLYTDVDELNDSDSETY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
84	Phosphorylation	PLHRAVASCSEEAVQ HHHHHHHCCCHHHHH	16.16	17203969
308	Phosphorylation	MKSKDGKTPLHMTAL CCCCCCCCCCHHEEE	36.29	22871156
313	Phosphorylation	GKTPLHMTALHGRFS CCCCCHHEEECCCCC	18.47	22871156
528	Phosphorylation	LQLIASETPLDVLME HHHHHCCCCCHHHHH	27.02	21183079
671	Phosphorylation	GHTDCVYSLLNKGAN CCCHHHHHHHHCCCC	13.14	29899451
1007	Phosphorylation	INRYTNTSKTVSFEA HHCCCCCCCEEEEEE	28.53	-
1008	Ubiquitination	NRYTNTSKTVSFEAL HCCCCCCCEEEEEEE	51.40	22790023
1009	Phosphorylation	RYTNTSKTVSFEALP CCCCCCCEEEEEEEC	22.58	22324799
1009	O-linked_Glycosylation	RYTNTSKTVSFEALP CCCCCCCEEEEEEEC	22.58	55410887
1011	Phosphorylation	TNTSKTVSFEALPIM CCCCCEEEEEEECCC	23.70	23527152

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANR28_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANR28_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANR28_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PPP6_HUMAN	PPP6C	physical	26496610
ARHG2_HUMAN	ARHGEF2	physical	26496610
NGAP_HUMAN	RASAL2	physical	26496610
PP6R2_HUMAN	PPP6R2	physical	26496610
PP6R1_HUMAN	PPP6R1	physical	26496610
PP6R3_HUMAN	PPP6R3	physical	26496610
KDEL1_HUMAN	KDELC1	physical	26496610
ANR52_HUMAN	ANKRD52	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-84, AND MASSSPECTROMETRY.
PubMed: 17203969