KI21A_MOUSE - dbPTM
KI21A_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KI21A_MOUSE
UniProt AC Q9QXL2
Protein Name Kinesin-like protein KIF21A
Gene Name Kif21a
Organism Mus musculus (Mouse).
Sequence Length 1672
Subcellular Localization Cytoplasm, cytoskeleton . Cell projection, dendrite . Cell projection, axon . In neurons, localized to axons and dendrites.
Protein Description Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity..
Protein Sequence MLGAADESSVRVAVRIRPQLAKEKIEGCHICTSVTPGEPQVFLGKDKAFTFDYVFDIDSQQEQIYTQCIEKLIEGCFEGYNATVFAYGQTGAGKTYTMGTGFDVNIMEEEQGIISRAVRHLFKSIDEKKTSAIKNGLPPPEFKVNAQFLELYNEEVLDLFDTTRDIDAKNKKSNIRIHEDSTGGIYTVGVTTRTVNTEPEMMQCLKLGALSRTTASTQMNVQSSRSHAIFTIHVCQTRVCPQTDAENATDNKLISESSPMNEFETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDKSKRATHVPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVMVNQDRASQQINALRSEITRLQMELMEYKTGKRIIDEEGVESINDMFHENAMLQTENNNLRVRIKAMQETVDALRARITQLVSEQANQVLARAGEGNEEISNMIHSYIKEIEDLRAKLLESEAVNENLRKNLTRATARSPYFSASSAFSPTILSSDKETIEIIDLAKKDLEKLKRKEKKKKKRLQKLEESGREERSVAGKDDNADTDQEKKEEKGVSEKENNELDVEENQEVSDHEDEEEEEEDEEEEDDIEGEESSDESDSESDEKANYQADLANITCEIAIKQKLIDELENSQKRLQTLKKQYEEKLMMLQHKIRDTQLERDQVLQNLGSVESYSEEKAKKVKCEYEKKLHAMNKELQRLQTAQKEHARLLKNQSQYEKQLKKLQQDVMEMKKTKVRLMKQMKEEQEKARLTESRRNREIAQLKKDQRKRDHQLRLLEAQKRNQEVVLRRKTEEVTALRRQVRPMSDKVAGKVTRKLSSSESPAPDTGSSAASGEADTSRPGTQQKMRIPVARVQALPTPTTNGTRKKYQRKGFTGRVFTSKTARMKWQLLERRVTDIIMQKMTISNMEADMNRLLRQREELTKRREKLSKRREKIVKESGEGDKSVANIIEEMESLTANIDYINDSIADCQANIMQMEEAKEEGETLDVTAVINACTLTEARYLLDHFLSMGINKGLQAAQKEAQIKVLEGRLKQTEITSATQNQLLFHMLKEKAELNPELDALLGHALQDLDGAPPENEEDSSEEDGPLHSPGSEGSTLSSDLMKLCGEVKPKNKARRRTTTQMELLYADSSEVASDTSAGDASLSGPLAPVAEGQEIGMNTETSGTSARDKELLAPSGLPSKIGSISRQSSLSEKKVPEPSPVTRRKAYEKADKPKAKEHKHSDSGASETSLSPPSSPPSRPRNELNVFNRLTVPQGTPSVQQDKSDESDSSLSEVHRGIINPFPACKGVRASPLQCVHIAEGHTKAVLCVDSTDDLLFTGSKDRTCKVWNLVTGQEIMSLGVHPNNVVSVKYCNYTSLVFTVSTSYIKVWDIRESAKCIRTLTSSGQVTLGEACSASTSRTVAIPSGESQINQIALNPTGTFLYAASGNAVRMWDLKRFQSTGKLTGHLGPVMCLTVDQISNGQDLIITGSKDHYIKMFDVTEGALGTVSPTHNFEPPHYDGIEALAIQGDNLFSGSRDNGIKKWDLAQKGLLQQVPNAHKDWVCALGLVPGHPVLLSGCRGGILKLWNVDTFVPVGEMRGHDSPINAICVNSTHVFTAADDRTVRIWKAHNLQDGQLSDTGDLGEDIASN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MLGAADES
-------CCCCCCHH		35.87-
80PhosphorylationIEGCFEGYNATVFAY
HHHHHCCCCEEEEEE		8.4017203969
87PhosphorylationYNATVFAYGQTGAGK
CCEEEEEECCCCCCC		9.7817203969
211PhosphorylationCLKLGALSRTTASTQ
HHHHCCCCCCCCCCC		27.3522324799
223PhosphorylationSTQMNVQSSRSHAIF
CCCCCCCCCCCCEEE		24.3625521595
224PhosphorylationTQMNVQSSRSHAIFT
CCCCCCCCCCCEEEE		22.2525521595
255PhosphorylationATDNKLISESSPMNE
CCCCCCCCCCCCCHH		41.6927180971
257PhosphorylationDNKLISESSPMNEFE
CCCCCCCCCCCHHHH		32.7129899451
258PhosphorylationNKLISESSPMNEFET
CCCCCCCCCCHHHHH		24.9025521595
265PhosphorylationSPMNEFETLTAKFHF
CCCHHHHHHHEEEEE		34.4324925903
278PhosphorylationHFVDLAGSERLKRTG
EEEECCCCHHHHHCC		17.59-
287O-linked_GlycosylationRLKRTGATGERAKEG
HHHHCCCCCCHHHCC		40.7030059200
454PhosphorylationDALRARITQLVSEQA
HHHHHHHHHHHHHHH		15.42-
516PhosphorylationRATARSPYFSASSAF
HHHHCCCCCCCCCCC		16.0629899451
518PhosphorylationTARSPYFSASSAFSP
HHCCCCCCCCCCCCC		22.7729899451
520PhosphorylationRSPYFSASSAFSPTI
CCCCCCCCCCCCCEE		22.4720415495
521PhosphorylationSPYFSASSAFSPTIL
CCCCCCCCCCCCEEC		32.8020415495
524PhosphorylationFSASSAFSPTILSSD
CCCCCCCCCEECCCC		22.3525521595
526PhosphorylationASSAFSPTILSSDKE
CCCCCCCEECCCCHH		33.0924925903
529PhosphorylationAFSPTILSSDKETIE
CCCCEECCCCHHHHH		32.4226060331
530PhosphorylationFSPTILSSDKETIEI
CCCEECCCCHHHHHH		49.6229472430
534PhosphorylationILSSDKETIEIIDLA
ECCCCHHHHHHHHHH		29.6529899451
558 (in isoform 2)Phosphorylation-51.7529899451
558 (in isoform 3)Phosphorylation-51.7529899451
568 (in isoform 2)Phosphorylation-62.3825521595
568 (in isoform 3)Phosphorylation-62.3825521595
571PhosphorylationESGREERSVAGKDDN
HCCHHHHHHCCCCCC		21.4323684622
581PhosphorylationGKDDNADTDQEKKEE
CCCCCCCCHHHHHHH		36.8525521595
669PhosphorylationLIDELENSQKRLQTL
HHHHHHHHHHHHHHH		27.92-
749UbiquitinationKEHARLLKNQSQYEK
HHHHHHHHCHHHHHH		58.49-
843PhosphorylationRRQVRPMSDKVAGKV
HHHHCCCCHHHCHHH		36.6429514104
851PhosphorylationDKVAGKVTRKLSSSE
HHHCHHHHHCCCCCC		26.1029109428
855PhosphorylationGKVTRKLSSSESPAP
HHHHHCCCCCCCCCC		34.5527742792
856PhosphorylationKVTRKLSSSESPAPD
HHHHCCCCCCCCCCC		48.8625521595
857PhosphorylationVTRKLSSSESPAPDT
HHHCCCCCCCCCCCC		38.4225521595
859PhosphorylationRKLSSSESPAPDTGS
HCCCCCCCCCCCCCC		28.4527742792
864PhosphorylationSESPAPDTGSSAASG
CCCCCCCCCCCCCCC		37.5925777480
866PhosphorylationSPAPDTGSSAASGEA
CCCCCCCCCCCCCCC		20.9225777480
867PhosphorylationPAPDTGSSAASGEAD
CCCCCCCCCCCCCCC		29.2425777480
870PhosphorylationDTGSSAASGEADTSR
CCCCCCCCCCCCCCC		36.5625777480
875PhosphorylationAASGEADTSRPGTQQ
CCCCCCCCCCCCCCH		33.4125777480
876PhosphorylationASGEADTSRPGTQQK
CCCCCCCCCCCCCHH		36.7025777480
880PhosphorylationADTSRPGTQQKMRIP
CCCCCCCCCHHCCCC		30.4325777480
909AcetylationTRKKYQRKGFTGRVF
CCHHHCCCCCCCCEE		42.7419852257
1060UbiquitinationKGLQAAQKEAQIKVL
HHHHHHHHHHHHHHH		50.74-
1101 (in isoform 2)Phosphorylation-19.8129899451
1102 (in isoform 2)Phosphorylation-6.1729899451
1110 (in isoform 2)Phosphorylation-4.1722324799
1113 (in isoform 2)Phosphorylation-19.0122324799
1116 (in isoform 2)Phosphorylation-75.9922324799
1117 (in isoform 2)Phosphorylation-64.8322324799
1119 (in isoform 2)Phosphorylation-74.8322324799
1120 (in isoform 2)Phosphorylation-51.8129899451
1121PhosphorylationPPENEEDSSEEDGPL
CCCCCCCCCCCCCCC		42.8222807455
1122PhosphorylationPENEEDSSEEDGPLH
CCCCCCCCCCCCCCC		58.2821183079
1130PhosphorylationEEDGPLHSPGSEGST
CCCCCCCCCCCCCCC		38.3421183079
1133PhosphorylationGPLHSPGSEGSTLSS
CCCCCCCCCCCCCCH		42.0129899451
1136PhosphorylationHSPGSEGSTLSSDLM
CCCCCCCCCCCHHHH		23.3229899451
1139PhosphorylationGSEGSTLSSDLMKLC
CCCCCCCCHHHHHHH		23.1521183079
1140PhosphorylationSEGSTLSSDLMKLCG
CCCCCCCHHHHHHHC		37.5629899451
1159PhosphorylationKNKARRRTTTQMELL
CCHHCCCCCCCEEEE		32.17-
1160PhosphorylationNKARRRTTTQMELLY
CHHCCCCCCCEEEEE		17.14-
1161PhosphorylationKARRRTTTQMELLYA
HHCCCCCCCEEEEEC		25.88-
1205 (in isoform 2)Phosphorylation-30.9821183079
1207 (in isoform 2)Phosphorylation-25.4921183079
1210 (in isoform 2)Phosphorylation-48.8021183079
1212 (in isoform 2)Phosphorylation-53.9922807455
1213 (in isoform 2)Phosphorylation-6.4322807455
1215 (in isoform 2)Phosphorylation-14.6129899451
1224PhosphorylationSGLPSKIGSISRQSS
CCCCHHHHCCCCCCC		23.74-
1225PhosphorylationGLPSKIGSISRQSSL
CCCHHHHCCCCCCCC		22.3623984901
1227PhosphorylationPSKIGSISRQSSLSE
CHHHHCCCCCCCCCC		26.4323737553
1228PhosphorylationSKIGSISRQSSLSEK
HHHHCCCCCCCCCCC		38.44-
1230PhosphorylationIGSISRQSSLSEKKV
HHCCCCCCCCCCCCC		31.9422324799
1231PhosphorylationGSISRQSSLSEKKVP
HCCCCCCCCCCCCCC		27.8122324799
1233PhosphorylationISRQSSLSEKKVPEP
CCCCCCCCCCCCCCC		49.6823984901
1241PhosphorylationEKKVPEPSPVTRRKA
CCCCCCCCCCCHHHH		30.2725521595
1244PhosphorylationVPEPSPVTRRKAYEK
CCCCCCCCHHHHHHH		28.3021082442
1263PhosphorylationKAKEHKHSDSGASET
CCCCCCCCCCCCCCC		37.9722871156
1265PhosphorylationKEHKHSDSGASETSL
CCCCCCCCCCCCCCC		38.9929472430
1268PhosphorylationKHSDSGASETSLSPP
CCCCCCCCCCCCCCC		44.9529472430
1270PhosphorylationSDSGASETSLSPPSS
CCCCCCCCCCCCCCC		32.2629899451
1271PhosphorylationDSGASETSLSPPSSP
CCCCCCCCCCCCCCC		23.8529472430
1273PhosphorylationGASETSLSPPSSPPS
CCCCCCCCCCCCCCC		34.2327818261
1276PhosphorylationETSLSPPSSPPSRPR
CCCCCCCCCCCCCCC		59.8829472430
1277PhosphorylationTSLSPPSSPPSRPRN
CCCCCCCCCCCCCCC		46.7521082442
1280PhosphorylationSPPSSPPSRPRNELN
CCCCCCCCCCCCCCC		59.3022817900
1306PhosphorylationPSVQQDKSDESDSSL
CCCCCCCCCCCCCCH		55.7029899451
1309PhosphorylationQQDKSDESDSSLSEV
CCCCCCCCCCCHHHH		48.0229899451
1311PhosphorylationDKSDESDSSLSEVHR
CCCCCCCCCHHHHHH		42.3229899451
1314PhosphorylationDESDSSLSEVHRGII
CCCCCCHHHHHHHCC		39.25-
1393PhosphorylationNNVVSVKYCNYTSLV
CCEEEEEECCCEEEE		5.4726643407
1396PhosphorylationVSVKYCNYTSLVFTV
EEEEECCCEEEEEEE		8.3126643407
1397PhosphorylationSVKYCNYTSLVFTVS
EEEECCCEEEEEEEE		11.1226643407
1398PhosphorylationVKYCNYTSLVFTVST
EEECCCEEEEEEEEC		16.5126643407
1402PhosphorylationNYTSLVFTVSTSYIK
CCEEEEEEEECCEEE		13.1826643407
1404PhosphorylationTSLVFTVSTSYIKVW
EEEEEEEECCEEEEE		14.4726643407
1405PhosphorylationSLVFTVSTSYIKVWD
EEEEEEECCEEEEEE		22.6326643407
1406PhosphorylationLVFTVSTSYIKVWDI
EEEEEECCEEEEEEH		19.8426643407
1407PhosphorylationVFTVSTSYIKVWDIR
EEEEECCEEEEEEHH		12.5926643407
1625PhosphorylationGEMRGHDSPINAICV
HHHCCCCCCCCEEEE		23.2329899451
1660PhosphorylationNLQDGQLSDTGDLGE
CCCCCCCCCCCCCCH		25.8225521595
1662PhosphorylationQDGQLSDTGDLGEDI
CCCCCCCCCCCCHHH		29.2624925903
1671PhosphorylationDLGEDIASN------
CCCHHHHCC------		43.3225521595
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KI21A_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KI21A_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KI21A_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of KI21A_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KI21A_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1660 AND SER-1671, ANDMASS SPECTROMETRY.
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-80 AND TYR-87, AND MASSSPECTROMETRY.

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