PROF2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PROF2_MOUSE
• UniProt AC: Q9JJV2
• Protein Name: Profilin-2
• Gene Name: Pfn2
• Organism: Mus musculus (Mouse).
• Sequence Length: 140
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Description: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG..
• Protein Sequence: MAGWQSYVDNLMCDGCCQEAAIVGYCDAKYVWAATAGGVFQSITPVEIDMIVGKDREGFFTNGLTLGAKKCSVIRDSLYVDGDCTMDIRTKSQGGEPTYNVAVGRAGRVLVFVMGKEGVHGGGLNKKAYSMAKYLRDSGF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGWQSYVD ------CCCHHHHHH	28.12	-
30	Phosphorylation	VGYCDAKYVWAATAG HEEECCEEEEEEECC	11.71	-
91	Ubiquitination	CTMDIRTKSQGGEPT CEEEEEECCCCCCCE	30.82	22790023
98	Phosphorylation	KSQGGEPTYNVAVGR CCCCCCCEEEEEEEC	24.35	22817900
99	Phosphorylation	SQGGEPTYNVAVGRA CCCCCCEEEEEEECC	20.53	22817900
126	Ubiquitination	VHGGGLNKKAYSMAK CCCCCCCHHHHHHHH	43.77	27667366
129	Phosphorylation	GGLNKKAYSMAKYLR CCCCHHHHHHHHHHH	14.09	21920940
133	Ubiquitination	KKAYSMAKYLRDSGF HHHHHHHHHHHHCCC	35.85	22790023
138	Phosphorylation	MAKYLRDSGF----- HHHHHHHCCC-----	35.35	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PROF2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PROF2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PROF2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ROCK2_MOUSE	Rock2	physical	9463375
NCKP1_MOUSE	Nckap1	physical	9463375
DYN1_MOUSE	Dnm1	physical	9463375
SYN1_MOUSE	Syn1	physical	9463375
HS71B_MOUSE	Hspa1b	physical	9463375
SYN2_MOUSE	Syn2	physical	9463375
ACTB_MOUSE	Actb	physical	9463375
CYFP1_MOUSE	Cyfip1	physical	9463375
DYN1_MOUSE	Dnm1	physical	16319076
PROF1_MOUSE	Pfn1	physical	16319076
ENAH_MOUSE	Enah	physical	16319076
VASP_MOUSE	Vasp	physical	16319076
PCLO_MOUSE	Pclo	physical	10508862

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-99, AND MASSSPECTROMETRY.
PubMed: 18034455