MPP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MPP2_MOUSE
• UniProt AC: Q9WV34
• Protein Name: MAGUK p55 subfamily member 2
• Gene Name: Mpp2 {ECO:0000312|MGI:MGI:1858257}
• Organism: Mus musculus (Mouse).
• Sequence Length: 552
• Subcellular Localization: Cell projection, dendrite . Cell projection, dendritic spine membrane . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Cytoplasm, cytoskeleton . Membrane . Prominently expressed in the post-synaptic densities of dendritic
• Protein Description: Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (By similarity). In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression. [PubMed: 26880549 Seems to negatively regulate SRC function in epithelial cells (By similarity]
• Protein Sequence: MPVAATNSESAMQQVLDNLGSLPNATGAAELDLIFLRGIMESPIVRSLAKAHERLEETKLEAVRDNNLELVQEILRDLAELAEQSSTAAELARILQEPHFQSLLETHDSVASKTYETPPPSPGLDPTFSNQPVPPDAVRMVGIRKTAGEHLGVTFRVEGGELVIARILHGGMVAQQGLLHVGDIIKEVNGQPVGSDPRALQELLRSASGSVILKILPSYQEPHLPRQVFVKCHFDYDPARDSLSPCKEAGLRFNAGDLLQIVNQDDANWWQACHVEGGSAGLIPSQLLEEKRKAFVKRDLELTPTSGTLCGSLSGKKKKRMMYLTTKNAEFDRHELLIYEEVARMPPFRRKTLVLIGAQGVGRRSLKNKLILWDPDRYGTTVPYTSRRPKDSEREGQGYSFVSRGEMEADIRAGRYLEHGEYEGNLYGTRIDSIRGVVASGKVCVLDVNPQAVKVLRTAEFVPYVVFIEAPDYETLRAMNRAALESGVSTKQLTEADLRRTVEESSRIQRGYGHYFDLSLVNSNLERTFRELQTAMEKLRTEPQWVPVSWVY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10 (in isoform 2)	Phosphorylation	-	28.94	24759943
15 (in isoform 2)	Phosphorylation	-	4.00	24759943
18 (in isoform 2)	Phosphorylation	-	41.98	24759943
19 (in isoform 2)	Phosphorylation	-	5.00	24759943
42	Phosphorylation	FLRGIMESPIVRSLA HHHHHHCCHHHHHHH	11.53	25521595
59	Ubiquitination	HERLEETKLEAVRDN HHHHHHHHHHHHHCC	47.84	27667366
76	Ubiquitination	ELVQEILRDLAELAE HHHHHHHHHHHHHHH	42.43	27667366
86	Phosphorylation	AELAEQSSTAAELAR HHHHHHCCHHHHHHH	23.04	29899451
114	Phosphorylation	HDSVASKTYETPPPS CHHHHHCCCCCCCCC	24.89	24925903
115	Phosphorylation	DSVASKTYETPPPSP HHHHHCCCCCCCCCC	22.88	25521595
117	Phosphorylation	VASKTYETPPPSPGL HHHCCCCCCCCCCCC	30.59	25521595
121	Phosphorylation	TYETPPPSPGLDPTF CCCCCCCCCCCCCCC	37.06	25521595
127	Phosphorylation	PSPGLDPTFSNQPVP CCCCCCCCCCCCCCC	39.09	24925903
129	Phosphorylation	PGLDPTFSNQPVPPD CCCCCCCCCCCCCCC	36.71	24925903
208	Phosphorylation	QELLRSASGSVILKI HHHHHHCCCCEEEEE	32.61	29899451
303	Phosphorylation	VKRDLELTPTSGTLC HHCCCEECCCCCCCC	18.36	29899451
305	Phosphorylation	RDLELTPTSGTLCGS CCCEECCCCCCCCCC	34.26	20415495
306	Phosphorylation	DLELTPTSGTLCGSL CCEECCCCCCCCCCC	30.86	20415495
308	Phosphorylation	ELTPTSGTLCGSLSG EECCCCCCCCCCCCC	20.74	20415495
310	S-nitrosylation	TPTSGTLCGSLSGKK CCCCCCCCCCCCCCC	3.32	24895380
310	S-palmitoylation	TPTSGTLCGSLSGKK CCCCCCCCCCCCCCC	3.32	28680068
310	S-nitrosocysteine	TPTSGTLCGSLSGKK CCCCCCCCCCCCCCC	3.32	-
312	Phosphorylation	TSGTLCGSLSGKKKK CCCCCCCCCCCCCCC	20.54	25521595
314	Phosphorylation	GTLCGSLSGKKKKRM CCCCCCCCCCCCCCE	50.71	29899451
399	Ubiquitination	SEREGQGYSFVSRGE CCCCCCCCCEEECCC	7.34	27667366
528	Phosphorylation	VNSNLERTFRELQTA HCCHHHHHHHHHHHH	20.05	-
538 (in isoform 2)	Ubiquitination	-	30.13	22790023
538	Ubiquitination	ELQTAMEKLRTEPQW HHHHHHHHHHCCCCC	30.13	22790023
549	O-linked_Glycosylation	EPQWVPVSWVY---- CCCCEECCCCC----	12.54	55412729
555	Ubiquitination	VSWVY---------- CCCCC----------		27667366
555 (in isoform 2)	Ubiquitination	-		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MPP2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MPP2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MPP2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MPP2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42, AND MASSSPECTROMETRY.
PubMed: 17114649