CSKI1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CSKI1_MOUSE
• UniProt AC: Q6P9K8
• Protein Name: Caskin-1
• Gene Name: Caskin1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1431
• Subcellular Localization: Cytoplasm.
• Protein Description: May link the scaffolding protein CASK to downstream intracellular effectors..
• Protein Sequence: MGKEQELVQAVKAEDVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNVPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDTTDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSGTALHEAALCGKTEVVRLLLDSGINAQVRNTYSQTALDIVHQFTTSQASKEIKQLLREASAALQVRATKDYCNNYDLTSLNVKAGDIITVLEQHPDGRWKGCIHDNRTGNDRVGYFPSSLGEAIVKRAGSRTGSEPSPPQGGGSLGPSAPPEEIWVLRKPFAGGDRSGSLSNVAGGRSTGGHALHAGSEGVKLLATVLSQKSVSESSPGDSPVKPPEGSSGAARSQPPAAHAGQVYGEQPPKKLESASASASEGKSAEAVSQWLATFQLQLYAPNFTSAGYDLPTISRMTPEDLTAIGVTKPGHRKKITAEISGLNIPDWLPEHKPANLAVWLSMIGLAQYYKVLVDNGYENIDFITDITWEDLQEIGITKLGHQKKLMLAVRKLAELQKAEYSKYEGGPLRRKTPQSLEMMAIESPPPSEPAAAECQSPKMTTFQDSELSGELQAALSGPAEAGAAAVEKSSNHLPPTPRTTSRESSLSGRARHISSSQELLGDGPPGPGSPMSRSQEYLLDEGMAPGTPPKEVRSSRHGHSVKRASVPPVPGKPRQVLPSGASHFTPPQTPTKAQPGSPQALGGPHGPATAKVKPTPQLLPPTDRPMSPRSLPQSPTHRGFAYVLPQPVEGEVGPPAPGPAPPPVPAAVPTLCLPPETDVEPGRPKKRAHSLNRYAASDSEPERDELLVPAAAGPYATVQRRVGRSHSVRAPAGTDKNVNRSQSFAVRPRKKGPPPPPPKRSSSAMASANLADEPAPDVEAEDGRLGVRAQRRRASDLAGSVDTGSAGSVKSIAAMLELSSIGGGGRAIRRPPEGHPTPRPASPEPGRVATVLASVKHKEAIGPDGEVVNRRRTLSGPVTGLLATARRGSGEPAEQSHFMEDGTARQRLRGPAKGEASAEGPPLARVEASATLKRRIRAKQSQQENVKFILTESDTVKRRPKAKEPDTGPEPPPPLSVYQNGTATVRRRPTSEQAGPPELPPPPPPAEPPPADLMQLPPLPLPDGNARKPVKPPVSPKPILSQPVSKIQGSPTPASKKVPLPGPGSPEVKRAHGTPPPVSPKPPPPPTAPKPAKALAGLQSSSATPSPVPSPARQPPAALIKPASSPPSQSASPVKPPSPGTPALHVPAKPPRAAASVVSGPPVASDCASPGDSARQKLEETSACLAAALQAVEEKIRQEDGQGPRPSSIEEKSTGSILEDIGSMFDDLADQLDAMLE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Phosphorylation	GKAKLLGSTKKINVN CCCEECCCCCEEECC	36.70	29899451
252	Phosphorylation	INAQVRNTYSQTALD CCHHHCCCCCCHHHH	17.62	20415495
253	Phosphorylation	NAQVRNTYSQTALDI CHHHCCCCCCHHHHH	11.43	22817900
254	Phosphorylation	AQVRNTYSQTALDIV HHHCCCCCCHHHHHH	21.00	20415495
292	Phosphorylation	QVRATKDYCNNYDLT HHHHCCHHHCCCCCC	9.91	29899451
296	Phosphorylation	TKDYCNNYDLTSLNV CCHHHCCCCCCCCEE	9.80	29899451
351	Phosphorylation	AIVKRAGSRTGSEPS HHHHHHCCCCCCCCC	26.19	29899451
353	Phosphorylation	VKRAGSRTGSEPSPP HHHHCCCCCCCCCCC	46.92	25293948
355	Phosphorylation	RAGSRTGSEPSPPQG HHCCCCCCCCCCCCC	45.80	25293948
358	Phosphorylation	SRTGSEPSPPQGGGS CCCCCCCCCCCCCCC	45.20	25521595
365	Phosphorylation	SPPQGGGSLGPSAPP CCCCCCCCCCCCCCH	33.17	24925903
369	Phosphorylation	GGGSLGPSAPPEEIW CCCCCCCCCCHHHEE	52.16	24925903
388	Phosphorylation	PFAGGDRSGSLSNVA CCCCCCCCCCCCCCC	37.16	22324799
390	Phosphorylation	AGGDRSGSLSNVAGG CCCCCCCCCCCCCCC	29.85	25521595
392	Phosphorylation	GDRSGSLSNVAGGRS CCCCCCCCCCCCCCC	30.84	28066266
398	Methylation	LSNVAGGRSTGGHAL CCCCCCCCCCCCCCC	30.08	-
417	Phosphorylation	EGVKLLATVLSQKSV HHHHHHHHHHHCCCC	23.19	22817900
420	Phosphorylation	KLLATVLSQKSVSES HHHHHHHHCCCCCCC	31.09	22324799
423	Phosphorylation	ATVLSQKSVSESSPG HHHHHCCCCCCCCCC	24.20	25521595
425	Phosphorylation	VLSQKSVSESSPGDS HHHCCCCCCCCCCCC	38.56	29899451
427	Phosphorylation	SQKSVSESSPGDSPV HCCCCCCCCCCCCCC	34.03	22817900
428	Phosphorylation	QKSVSESSPGDSPVK CCCCCCCCCCCCCCC	28.93	25521595
432	Phosphorylation	SESSPGDSPVKPPEG CCCCCCCCCCCCCCC	37.19	22817900
471	Phosphorylation	KLESASASASEGKSA HHHHCCCCCCCCCCH	29.81	29899451
473	Phosphorylation	ESASASASEGKSAEA HHCCCCCCCCCCHHH	44.37	29899451
522	Ubiquitination	LTAIGVTKPGHRKKI HHEEECCCCCCCCCE	46.74	22790023
626	Phosphorylation	GGPLRRKTPQSLEMM CCCCCCCCCCCEEEE	25.42	24925903
629	Phosphorylation	LRRKTPQSLEMMAIE CCCCCCCCEEEEEEC	27.74	24925903
637	Phosphorylation	LEMMAIESPPPSEPA EEEEEECCCCCCCCC	36.27	24925903
641	Phosphorylation	AIESPPPSEPAAAEC EECCCCCCCCCHHHC	63.08	29899451
650	Phosphorylation	PAAAECQSPKMTTFQ CCHHHCCCCCCCCCC	37.84	25521595
695	Phosphorylation	PPTPRTTSRESSLSG CCCCCCCCCCHHCCC	33.18	29899451
698	Phosphorylation	PRTTSRESSLSGRAR CCCCCCCHHCCCCCE	35.15	29899451
699	Phosphorylation	RTTSRESSLSGRARH CCCCCCHHCCCCCEE	23.08	29899451
708	Phosphorylation	SGRARHISSSQELLG CCCCEEECCCHHHHC	20.15	26643407
709	Phosphorylation	GRARHISSSQELLGD CCCEEECCCHHHHCC	35.12	26643407
710	Phosphorylation	RARHISSSQELLGDG CCEEECCCHHHHCCC	22.38	26643407
723	Phosphorylation	DGPPGPGSPMSRSQE CCCCCCCCCCCHHHH	22.14	22324799
726	Phosphorylation	PGPGSPMSRSQEYLL CCCCCCCCHHHHHHH	31.97	28066266
728	Phosphorylation	PGSPMSRSQEYLLDE CCCCCCHHHHHHHHC	21.76	22817900
731	Phosphorylation	PMSRSQEYLLDEGMA CCCHHHHHHHHCCCC	12.62	29899451
741	Phosphorylation	DEGMAPGTPPKEVRS HCCCCCCCCCHHHHC	35.05	26643407
748	Phosphorylation	TPPKEVRSSRHGHSV CCCHHHHCCCCCCCC	36.58	24719451
759	Phosphorylation	GHSVKRASVPPVPGK CCCCCCCCCCCCCCC	38.91	22807455
773	Phosphorylation	KPRQVLPSGASHFTP CCCCCCCCCCCCCCC	42.71	30372032
776	Phosphorylation	QVLPSGASHFTPPQT CCCCCCCCCCCCCCC	23.74	24759943
779	Phosphorylation	PSGASHFTPPQTPTK CCCCCCCCCCCCCCC	28.74	24925903
783	Phosphorylation	SHFTPPQTPTKAQPG CCCCCCCCCCCCCCC	38.40	24925903
785	Phosphorylation	FTPPQTPTKAQPGSP CCCCCCCCCCCCCCC	42.26	24925903
791	Phosphorylation	PTKAQPGSPQALGGP CCCCCCCCCCHHCCC	22.11	25521595
803	Phosphorylation	GGPHGPATAKVKPTP CCCCCCCCCCCCCCC	30.09	24925903
816	Phosphorylation	TPQLLPPTDRPMSPR CCCCCCCCCCCCCCC	42.58	22324799
821	Phosphorylation	PPTDRPMSPRSLPQS CCCCCCCCCCCCCCC	21.61	28978645
824	O-linked_Glycosylation	DRPMSPRSLPQSPTH CCCCCCCCCCCCCCC	48.03	44699641
824	Phosphorylation	DRPMSPRSLPQSPTH CCCCCCCCCCCCCCC	48.03	28066266
828	Phosphorylation	SPRSLPQSPTHRGFA CCCCCCCCCCCCCEE	29.81	25521595
830	Phosphorylation	RSLPQSPTHRGFAYV CCCCCCCCCCCEEEE	29.47	28066266
884	Phosphorylation	RPKKRAHSLNRYAAS CCCCCHHHHCCCCCC	26.76	22324799
888	Phosphorylation	RAHSLNRYAASDSEP CHHHHCCCCCCCCCC	12.87	26643407
891	Phosphorylation	SLNRYAASDSEPERD HHCCCCCCCCCCCHH	33.23	18388127
893	Phosphorylation	NRYAASDSEPERDEL CCCCCCCCCCCHHHC	53.18	18388127
909	Phosphorylation	VPAAAGPYATVQRRV EECCCCCCHHHHCCC	17.62	20415495
911	Phosphorylation	AAAGPYATVQRRVGR CCCCCCHHHHCCCCC	16.01	20415495
919	Phosphorylation	VQRRVGRSHSVRAPA HHCCCCCCCCCCCCC	17.74	29899451
921	Phosphorylation	RRVGRSHSVRAPAGT CCCCCCCCCCCCCCC	17.97	29899451
935	Phosphorylation	TDKNVNRSQSFAVRP CCCCCCHHHCCCCCC	25.60	29514104
937	Phosphorylation	KNVNRSQSFAVRPRK CCCCHHHCCCCCCCC	19.20	21454597
955	Phosphorylation	PPPPPKRSSSAMASA CCCCCCCCCCHHHHC	34.47	23527152
956	Phosphorylation	PPPPKRSSSAMASAN CCCCCCCCCHHHHCC	26.58	29899451
957	Phosphorylation	PPPKRSSSAMASANL CCCCCCCCHHHHCCC	24.26	25521595
961	Phosphorylation	RSSSAMASANLADEP CCCCHHHHCCCCCCC	12.47	23527152
989	Phosphorylation	RAQRRRASDLAGSVD HHHHHHHHHHCCCCC	31.20	25521595
994	Phosphorylation	RASDLAGSVDTGSAG HHHHHCCCCCCCCCC	15.94	26643407
999	Phosphorylation	AGSVDTGSAGSVKSI CCCCCCCCCCCHHHH	31.39	24759943
1002	Phosphorylation	VDTGSAGSVKSIAAM CCCCCCCCHHHHHHH	26.53	29899451
1031	Phosphorylation	RPPEGHPTPRPASPE CCCCCCCCCCCCCCC	26.67	26643407
1036	Phosphorylation	HPTPRPASPEPGRVA CCCCCCCCCCCCCCC	32.26	23527152
1048	Phosphorylation	RVATVLASVKHKEAI CCCEEEEECCCHHHH	27.77	22324799
1067	Phosphorylation	EVVNRRRTLSGPVTG CEECCCCCCCCCHHH	24.38	21082442
1069	Phosphorylation	VNRRRTLSGPVTGLL ECCCCCCCCCHHHHH	40.20	21082442
1073	Phosphorylation	RTLSGPVTGLLATAR CCCCCCHHHHHHHHC	25.83	29899451
1078	Phosphorylation	PVTGLLATARRGSGE CHHHHHHHHCCCCCC	22.21	29899451
1083	Phosphorylation	LATARRGSGEPAEQS HHHHCCCCCCCCHHH	37.87	25521595
1097	Phosphorylation	SHFMEDGTARQRLRG HCCCCCCCHHHHHCC	30.87	-
1123	Phosphorylation	PLARVEASATLKRRI CCCCHHHHHHHHHHH	14.31	29899451
1125	Phosphorylation	ARVEASATLKRRIRA CCHHHHHHHHHHHHH	30.25	23140645
1149	Phosphorylation	FILTESDTVKRRPKA EEEECCHHHCCCCCC	36.89	29899451
1229	Phosphorylation	KPVKPPVSPKPILSQ CCCCCCCCCCCCCCC	32.74	29899451
1244	Phosphorylation	PVSKIQGSPTPASKK CCHHCCCCCCCCCCC	14.82	25521595
1246	Phosphorylation	SKIQGSPTPASKKVP HHCCCCCCCCCCCCC	32.93	25521595
1249	Phosphorylation	QGSPTPASKKVPLPG CCCCCCCCCCCCCCC	33.92	28066266
1259	Phosphorylation	VPLPGPGSPEVKRAH CCCCCCCCHHHHHHC	22.48	25521595
1268	Phosphorylation	EVKRAHGTPPPVSPK HHHHHCCCCCCCCCC	23.82	30372032
1273	Phosphorylation	HGTPPPVSPKPPPPP CCCCCCCCCCCCCCC	32.74	28978645
1281	Phosphorylation	PKPPPPPTAPKPAKA CCCCCCCCCCCCHHH	62.46	20415495
1294	Phosphorylation	KALAGLQSSSATPSP HHHHCCCCCCCCCCC	31.16	26643407
1295	Phosphorylation	ALAGLQSSSATPSPV HHHCCCCCCCCCCCC	15.84	26643407
1296	Phosphorylation	LAGLQSSSATPSPVP HHCCCCCCCCCCCCC	41.21	26643407
1298	Phosphorylation	GLQSSSATPSPVPSP CCCCCCCCCCCCCCC	26.67	30372032
1300	Phosphorylation	QSSSATPSPVPSPAR CCCCCCCCCCCCCCC	33.89	26643407
1304	Phosphorylation	ATPSPVPSPARQPPA CCCCCCCCCCCCCCC	31.27	30372032
1318	Phosphorylation	AALIKPASSPPSQSA CCEECCCCCCCCCCC	52.48	24925903
1319	Phosphorylation	ALIKPASSPPSQSAS CEECCCCCCCCCCCC	42.83	24925903
1322	Phosphorylation	KPASSPPSQSASPVK CCCCCCCCCCCCCCC	39.90	26643407
1324	Phosphorylation	ASSPPSQSASPVKPP CCCCCCCCCCCCCCC	34.74	26643407
1326	Phosphorylation	SPPSQSASPVKPPSP CCCCCCCCCCCCCCC	35.16	26643407
1332	Phosphorylation	ASPVKPPSPGTPALH CCCCCCCCCCCCCCC	44.48	24925903
1335	Phosphorylation	VKPPSPGTPALHVPA CCCCCCCCCCCCCCC	14.58	24925903
1359	Phosphorylation	VSGPPVASDCASPGD CCCCCCHHHCCCCCH	33.19	24925903
1363	Phosphorylation	PVASDCASPGDSARQ CCHHHCCCCCHHHHH	35.43	25521595
1367	Phosphorylation	DCASPGDSARQKLEE HCCCCCHHHHHHHHH	31.13	24925903
1401	Phosphorylation	DGQGPRPSSIEEKST CCCCCCCCCCHHHCC	45.27	29899451
1402	Phosphorylation	GQGPRPSSIEEKSTG CCCCCCCCCHHHCCC	36.38	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CSKI1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CSKI1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CSKI1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CSKI1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-650; THR-779; SER-791;SER-1259 AND SER-1363, AND MASS SPECTROMETRY.
PubMed: 17114649

"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations.";
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.;
Mol. Cell. Proteomics 5:914-922(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1067; SER-1069; SER-1259AND SER-1363, AND MASS SPECTROMETRY.
PubMed: 16452087

"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-253, AND MASSSPECTROMETRY.
PubMed: 18034455