ERC2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ERC2_MOUSE
• UniProt AC: Q6PH08
• Protein Name: ERC protein 2
• Gene Name: Erc2
• Organism: Mus musculus (Mouse).
• Sequence Length: 957
• Subcellular Localization: Cytoplasm . Cell junction, synapse . Cell junction, synapse, synaptosome . Cytoplasm, cytoskeleton . Localized to the active zone of presynaptic density.
• Protein Description: Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ..
• Protein Sequence: MYGSARTISNLEGSPSRSPRLPRSPRLGHRRTSSGGGGGTGKTLSMENIQSLNAAYATSGPMYLSDHEGVASTTYPKGTMTLGRATNRAVYGGRVTAMGSSPNIASAGLSHTDVLSYTDQHGGLSGSSHHHHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEVQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECNKLEAQLKKAHNIEDDSRMNPEFADRLKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKYNQQLEKKKNAQLLEEVRRREDSMVDNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEEVMALKREKDRLVHQLKQQTQNRMKLMADNYDEDHHHYHHHHHHHHHRSPGRSQHSNHRPSPDQDDEEGIWA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MYGSARTIS ------CCCCCCCCC	21.56	21183079
7	O-linked_Glycosylation	-MYGSARTISNLEGS -CCCCCCCCCCCCCC	28.59	55411901
7	Phosphorylation	-MYGSARTISNLEGS -CCCCCCCCCCCCCC	28.59	-
9	Phosphorylation	YGSARTISNLEGSPS CCCCCCCCCCCCCCC	34.45	29472430
14	Phosphorylation	TISNLEGSPSRSPRL CCCCCCCCCCCCCCC	15.44	25521595
16	Phosphorylation	SNLEGSPSRSPRLPR CCCCCCCCCCCCCCC	47.27	29472430
18	Phosphorylation	LEGSPSRSPRLPRSP CCCCCCCCCCCCCCC	20.79	25521595
24	Phosphorylation	RSPRLPRSPRLGHRR CCCCCCCCCCCCCCC	16.66	27149854
32	Phosphorylation	PRLGHRRTSSGGGGG CCCCCCCCCCCCCCC	27.48	29899451
33	Phosphorylation	RLGHRRTSSGGGGGT CCCCCCCCCCCCCCC	25.77	29899451
43	Phosphorylation	GGGGTGKTLSMENIQ CCCCCCCCCCHHHHH	25.96	19060867
45	Phosphorylation	GGTGKTLSMENIQSL CCCCCCCCHHHHHHH	29.31	19060867
51	Phosphorylation	LSMENIQSLNAAYAT CCHHHHHHHHHHHCC	21.57	29899451
63	Phosphorylation	YATSGPMYLSDHEGV HCCCCCEECCCCCCC	13.24	29899451
65	Phosphorylation	TSGPMYLSDHEGVAS CCCCEECCCCCCCCC	21.31	21183079
178	Phosphorylation	KDSKLGSSMNSIKTF CHHCCCCCHHHHHHH	21.86	-
184	Phosphorylation	SSMNSIKTFWSPELK CCHHHHHHHCCHHHH	28.77	25777480
187	Phosphorylation	NSIKTFWSPELKKER HHHHHHCCHHHHHHH	12.33	27149854
198	Acetylation	KKERVLRKEEAARMS HHHHHHCHHHHHHHH	56.60	155993
319	Phosphorylation	LQSKGLPSKSLEDDN HHHCCCCCCCCCCHH	39.66	20415495
321	Phosphorylation	SKGLPSKSLEDDNER HCCCCCCCCCCHHHH	41.13	20415495
364	Phosphorylation	REELHRRSQLQPEPA HHHHHHHHCCCCCCH	34.89	29899451
373	O-linked_Glycosylation	LQPEPAKTKALQTVI CCCCCHHHHHHHHHH	24.53	55411909
389	Phosphorylation	MKDTKIASLERNIRD HCHHHHHHHHHHHCH	33.95	-
427	Phosphorylation	KQIEVYKSHSKFMKT HHHHHHHHHHHHHHH	18.46	29899451
547	Malonylation	KINVLQKKIENLQEQ HHHHHHHHHHHHHHH	42.14	26320211
579	Phosphorylation	LQTDSSNTDTALATL HHCCCCCHHHHHHHH	36.35	29899451
647	Ubiquitination	ESSLIDLKEHASSLA HHCHHHHHHHHHHHH	43.64	-
651	Phosphorylation	IDLKEHASSLASAGL HHHHHHHHHHHHHCC	28.00	25338131
652	Phosphorylation	DLKEHASSLASAGLK HHHHHHHHHHHHCCC	28.83	25338131
666	Phosphorylation	KRDSKLKSLEIAIEQ CCHHHCHHHHHHHHH	41.49	16141072
752	Phosphorylation	KKIAELESLTLRHMK HHHHHHHHHHHHHHH	39.00	22324799
754	Phosphorylation	IAELESLTLRHMKDQ HHHHHHHHHHHHHHC	30.90	22324799
792	Phosphorylation	EVRRREDSMVDNSQH HHHHHHHHCCCCCHH	18.89	29899451
797	Phosphorylation	EDSMVDNSQHLQIEE HHHCCCCCHHHCHHH	17.95	29899451
812	Phosphorylation	LMNALEKTRQELDAT HHHHHHHHHHHHHHH	28.36	-
876	Phosphorylation	NIALLELSASKKKKT HHHHHHHCCCCCCCC	22.56	29899451
934 (in isoform 3)	Phosphorylation	-	27.61	29233185
937 (in isoform 3)	Phosphorylation	-	36.21	29233185
942 (in isoform 3)	Phosphorylation	-	32.82	29233185
946	Phosphorylation	QHSNHRPSPDQDDEE CCCCCCCCCCCCCCC	40.85	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ERC2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ERC2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ERC2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ERC2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, AND MASSSPECTROMETRY.
PubMed: 17114649