| UniProt ID | PI42C_MOUSE | |
|---|---|---|
| UniProt AC | Q91XU3 | |
| Protein Name | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | |
| Gene Name | Pip4k2c | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 421 | |
| Subcellular Localization | Cytoplasm. Membrane. Mostly found in the cytosol and surrounding plasma membrane. However, its presence in the endoplasmic reticulum seems to be a prerequisite for PIP2 synthesis (By similarity).. | |
| Protein Description | May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum.. | |
| Protein Sequence | MASSSVPPATAPAAAGGPGPGFGFASKTKKKHFVQQKVKVFRAADPLVGVFLWGVAHSINELSQVPPPVMLLPDDFKASSKIKVNNHFFHRENLPSHFKFKEYCPQVFRNLRDRFAIDDHDYLVSLTRSPPSETEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVENEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKVFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEGPVREEESEWDGDCNLAGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGAEISTVHPEQYAKRFLDFIANIFA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MASSSVPPA ------CCCCCCCCC | 20.37 | - | |
| 26 | Phosphorylation | GPGFGFASKTKKKHF CCCCCCCCHHCHHHH | 38.30 | - | |
| 101 | Acetylation | LPSHFKFKEYCPQVF CCCCCCHHHHHHHHH | 48.65 | 22826441 | |
| 198 | Phosphorylation | VSVENEDSYMLVMRN EEECCCCCEEEEEHH | 13.28 | - | |
| 199 | Phosphorylation | SVENEDSYMLVMRNM EECCCCCEEEEEHHH | 13.54 | - | |
| 222 | Phosphorylation | RKYDLKGSLVSREAS CCCCCCCCCCCCCCC | 24.82 | 29176673 | |
| 349 | Phosphorylation | LGPGEFESFIDVYAI CCCCCCCCEEEEEEH | 32.59 | - | |
| 393 | Ubiquitination | AHAAKTVKHGAGAEI HHHHHHHHCCCCCEE | 41.37 | 27667366 | |
| 451 | Ubiquitination | ------------------------------------- ------------------------------------- | 27667366 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PI42C_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PI42C_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PI42C_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| LAMA5_HUMAN | LAMA5 | physical | 26496610 | |
| PI42A_HUMAN | PIP4K2A | physical | 26496610 | |
| RBM4_HUMAN | RBM4 | physical | 26496610 | |
| UBP1_HUMAN | USP1 | physical | 26496610 | |
| PI42B_HUMAN | PIP4K2B | physical | 26496610 | |
| CRIPT_HUMAN | CRIPT | physical | 26496610 | |
| CTR9_HUMAN | CTR9 | physical | 26496610 | |
| RUSC1_HUMAN | RUSC1 | physical | 26496610 | |
| TIDC1_HUMAN | TIMMDC1 | physical | 26496610 | |
| OTU6B_HUMAN | OTUD6B | physical | 26496610 | |
| ZN668_HUMAN | ZNF668 | physical | 26496610 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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