LAMA5_HUMAN - dbPTM
LAMA5_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LAMA5_HUMAN
UniProt AC O15230
Protein Name Laminin subunit alpha-5
Gene Name LAMA5
Organism Homo sapiens (Human).
Sequence Length 3695
Subcellular Localization Secreted, extracellular space, extracellular matrix, basement membrane. Major component.
Protein Description Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components..
Protein Sequence MAKRLCAGSALCVRGPRGPAPLLLVGLALLGAARAREEAGGGFSLHPPYFNLAEGARIAASATCGEEAPARGSPRPTEDLYCKLVGGPVAGGDPNQTIRGQYCDICTAANSNKAHPASNAIDGTERWWQSPPLSRGLEYNEVNVTLDLGQVFHVAYVLIKFANSPRPDLWVLERSMDFGRTYQPWQFFASSKRDCLERFGPQTLERITRDDAAICTTEYSRIVPLENGEIVVSLVNGRPGAMNFSYSPLLREFTKATNVRLRFLRTNTLLGHLMGKALRDPTVTRRYYYSIKDISIGGRCVCHGHADACDAKDPTDPFRLQCTCQHNTCGGTCDRCCPGFNQQPWKPATANSANECQSCNCYGHATDCYYDPEVDRRRASQSLDGTYQGGGVCIDCQHHTTGVNCERCLPGFYRSPNHPLDSPHVCRRCNCESDFTDGTCEDLTGRCYCRPNFSGERCDVCAEGFTGFPSCYPTPSSSNDTREQVLPAGQIVNCDCSAAGTQGNACRKDPRVGRCLCKPNFQGTHCELCAPGFYGPGCQPCQCSSPGVADDRCDPDTGQCRCRVGFEGATCDRCAPGYFHFPLCQLCGCSPAGTLPEGCDEAGRCLCQPEFAGPHCDRCRPGYHGFPNCQACTCDPRGALDQLCGAGGLCRCRPGYTGTACQECSPGFHGFPSCVPCHCSAEGSLHAACDPRSGQCSCRPRVTGLRCDTCVPGAYNFPYCEAGSCHPAGLAPVDPALPEAQVPCMCRAHVEGPSCDRCKPGFWGLSPSNPEGCTRCSCDLRGTLGGVAECQPGTGQCFCKPHVCGQACASCKDGFFGLDQADYFGCRSCRCDIGGALGQSCEPRTGVCRCRPNTQGPTCSEPARDHYLPDLHHLRLELEEAATPEGHAVRFGFNPLEFENFSWRGYAQMAPVQPRIVARLNLTSPDLFWLVFRYVNRGAMSVSGRVSVREEGRSATCANCTAQSQPVAFPPSTEPAFITVPQRGFGEPFVLNPGTWALRVEAEGVLLDYVVLLPSAYYEAALLQLRVTEACTYRPSAQQSGDNCLLYTHLPLDGFPSAAGLEALCRQDNSLPRPCPTEQLSPSHPPLITCTGSDVDVQLQVAVPQPGRYALVVEYANEDARQEVGVAVHTPQRAPQQGLLSLHPCLYSTLCRGTARDTQDHLAVFHLDSEASVRLTAEQARFFLHGVTLVPIEEFSPEFVEPRVSCISSHGAFGPNSAACLPSRFPKPPQPIILRDCQVIPLPPGLPLTHAQDLTPAMSPAGPRPRPPTAVDPDAEPTLLREPQATVVFTTHVPTLGRYAFLLHGYQPAHPTFPVEVLINAGRVWQGHANASFCPHGYGCRTLVVCEGQALLDVTHSELTVTVRVPKGRWLWLDYVLVVPENVYSFGYLREEPLDKSYDFISHCAAQGYHISPSSSSLFCRNAAASLSLFYNNGARPCGCHEVGATGPTCEPFGGQCPCHAHVIGRDCSRCATGYWGFPNCRPCDCGARLCDELTGQCICPPRTIPPDCLLCQPQTFGCHPLVGCEECNCSGPGIQELTDPTCDTDSGQCKCRPNVTGRRCDTCSPGFHGYPRCRPCDCHEAGTAPGVCDPLTGQCYCKENVQGPKCDQCSLGTFSLDAANPKGCTRCFCFGATERCRSSSYTRQEFVDMEGWVLLSTDRQVVPHERQPGTEMLRADLRHVPEAVPEAFPELYWQAPPSYLGDRVSSYGGTLRYELHSETQRGDVFVPMESRPDVVLQGNQMSITFLEPAYPTPGHVHRGQLQLVEGNFRHTETRNTVSREELMMVLASLEQLQIRALFSQISSAVFLRRVALEVASPAGQGALASNVELCLCPASYRGDSCQECAPGFYRDVKGLFLGRCVPCQCHGHSDRCLPGSGVCVDCQHNTEGAHCERCQAGFVSSRDDPSAPCVSCPCPLSVPSNNFAEGCVLRGGRTQCLCKPGYAGASCERCAPGFFGNPLVLGSSCQPCDCSGNGDPNLLFSDCDPLTGACRGCLRHTTGPRCEICAPGFYGNALLPGNCTRCDCTPCGTEACDPHSGHCLCKAGVTGRRCDRCQEGHFGFDGCGGCRPCACGPAAEGSECHPQSGQCHCRPGTMGPQCRECAPGYWGLPEQGCRRCQCPGGRCDPHTGRCNCPPGLSGERCDTCSQQHQVPVPGGPVGHSIHCEVCDHCVVLLLDDLERAGALLPAIHEQLRGINASSMAWARLHRLNASIADLQSQLRSPLGPRHETAQQLEVLEQQSTSLGQDARRLGGQAVGTRDQASQLLAGTEATLGHAKTLLAAIRAVDRTLSELMSQTGHLGLANASAPSGEQLLRTLAEVERLLWEMRARDLGAPQAAAEAELAAAQRLLARVQEQLSSLWEENQALATQTRDRLAQHEAGLMDLREALNRAVDATREAQELNSRNQERLEEALQRKQELSRDNATLQATLHAARDTLASVFRLLHSLDQAKEELERLAASLDGARTPLLQRMQTFSPAGSKLRLVEAAEAHAQQLGQLALNLSSIILDVNQDRLTQRAIEASNAYSRILQAVQAAEDAAGQALQQADHTWATVVRQGLVDRAQQLLANSTALEEAMLQEQQRLGLVWAALQGARTQLRDVRAKKDQLEAHIQAAQAMLAMDTDETSKKIAHAKAVAAEAQDTATRVQSQLQAMQENVERWQGQYEGLRGQDLGQAVLDAGHSVSTLEKTLPQLLAKLSILENRGVHNASLALSASIGRVRELIAQARGAASKVKVPMKFNGRSGVQLRTPRDLADLAAYTALKFYLQGPEPEPGQGTEDRFVMYMGSRQATGDYMGVSLRDKKVHWVYQLGEAGPAVLSIDEDIGEQFAAVSLDRTLQFGHMSVTVERQMIQETKGDTVAPGAEGLLNLRPDDFVFYVGGYPSTFTPPPLLRFPGYRGCIEMDTLNEEVVSLYNFERTFQLDTAVDRPCARSKSTGDPWLTDGSYLDGTGFARISFDSQISTTKRFEQELRLVSYSGVLFFLKQQSQFLCLAVQEGSLVLLYDFGAGLKKAVPLQPPPPLTSASKAIQVFLLGGSRKRVLVRVERATVYSVEQDNDLELADAYYLGGVPPDQLPPSLRRLFPTGGSVRGCVKGIKALGKYVDLKRLNTTGVSAGCTADLLVGRAMTFHGHGFLRLALSNVAPLTGNVYSGFGFHSAQDSALLYYRASPDGLCQVSLQQGRVSLQLLRTEVKTQAGFADGAPHYVAFYSNATGVWLYVDDQLQQMKPHRGPPPELQPQPEGPPRLLLGGLPESGTIYNFSGCISNVFVQRLLGPQRVFDLQQNLGSVNVSTGCAPALQAQTPGLGPRGLQATARKASRRSRQPARHPACMLPPHLRTTRDSYQFGGSLSSHLEFVGILARHRNWPSLSMHVLPRSSRGLLLFTARLRPGSPSLALFLSNGHFVAQMEGLGTRLRAQSRQRSRPGRWHKVSVRWEKNRILLVTDGARAWSQEGPHRQHQGAEHPQPHTLFVGGLPASSHSSKLPVTVGFSGCVKRLRLHGRPLGAPTRMAGVTPCILGPLEAGLFFPGSGGVITLDLPGATLPDVGLELEVRPLAVTGLIFHLGQARTPPYLQLQVTEKQVLLRADDGAGEFSTSVTRPSVLCDGQWHRLAVMKSGNVLRLEVDAQSNHTVGPLLAAAAGAPAPLYLGGLPEPMAVQPWPPAYCGCMRRLAVNRSPVAMTRSVEVHGAVGASGCPAA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Methylation----MAKRLCAGSAL
----CCCCCCCCCEE		41.90115383467
73O-linked_GlycosylationEEAPARGSPRPTEDL
CCCCCCCCCCCCHHC		16.51OGP
77O-linked_GlycosylationARGSPRPTEDLYCKL
CCCCCCCCHHCCEEC		43.33OGP
83UbiquitinationPTEDLYCKLVGGPVA
CCHHCCEECCCCCCC		32.4221963094
95N-linked_GlycosylationPVAGGDPNQTIRGQY
CCCCCCCCCCCCCEE		57.26UniProtKB CARBOHYD
97O-linked_GlycosylationAGGDPNQTIRGQYCD
CCCCCCCCCCCEECC		21.2028657654
113UbiquitinationCTAANSNKAHPASNA
HHHCCCCCCCCCCCC		48.1421963094
143N-linked_GlycosylationGLEYNEVNVTLDLGQ
CCCCCEEEEEEEHHH		18.19UniProtKB CARBOHYD
164PhosphorylationVLIKFANSPRPDLWV
HHHHHHCCCCCCEEE		20.8924719451
175PhosphorylationDLWVLERSMDFGRTY
CEEEEEECCCCCCCC		17.21-
181PhosphorylationRSMDFGRTYQPWQFF
ECCCCCCCCCHHHHH		27.2122817900
182PhosphorylationSMDFGRTYQPWQFFA
CCCCCCCCCHHHHHH		15.9522817900
191PhosphorylationPWQFFASSKRDCLER
HHHHHHCCHHHHHHH		28.4219690332
192UbiquitinationWQFFASSKRDCLERF
HHHHHCCHHHHHHHH		50.1621890473
192UbiquitinationWQFFASSKRDCLERF
HHHHHCCHHHHHHHH		50.1621963094
243N-linked_GlycosylationNGRPGAMNFSYSPLL
CCCCCCCCCCCHHHH		23.37UniProtKB CARBOHYD
245O-linked_GlycosylationRPGAMNFSYSPLLRE
CCCCCCCCCHHHHHH		21.5028657654
247PhosphorylationGAMNFSYSPLLREFT
CCCCCCCHHHHHHHH		14.1024719451
287PhosphorylationDPTVTRRYYYSIKDI
CCCCCCEEEEEEEEE		11.94-
288PhosphorylationPTVTRRYYYSIKDIS
CCCCCEEEEEEEEEE		6.74-
289PhosphorylationTVTRRYYYSIKDISI
CCCCEEEEEEEEEEE		8.59-
290PhosphorylationVTRRYYYSIKDISIG
CCCEEEEEEEEEEEC		13.6724719451
292UbiquitinationRRYYYSIKDISIGGR
CEEEEEEEEEEECCE		42.9721963094
452N-linked_GlycosylationGRCYCRPNFSGERCD
CCEEECCCCCCCCCC		25.10UniProtKB CARBOHYD
479N-linked_GlycosylationYPTPSSSNDTREQVL
CCCCCCCCCCCHHEE		57.53UniProtKB CARBOHYD
900N-linked_GlycosylationFNPLEFENFSWRGYA
CCCCCCCCCEECCCC		41.39UniProtKB CARBOHYD
921N-linked_GlycosylationPRIVARLNLTSPDLF
CEEEEECCCCCCHHH		35.40UniProtKB CARBOHYD
959N-linked_GlycosylationGRSATCANCTAQSQP
CCCCCCCCCCCCCCC		26.31UniProtKB CARBOHYD
1130PhosphorylationEVGVAVHTPQRAPQQ
HHEEEEECCCCCCCC		17.96-
1176PhosphorylationSEASVRLTAEQARFF
CCCCCCCCHHHHHHH		19.9923403867
1259O-linked_GlycosylationQDLTPAMSPAGPRPR
HHCCCCCCCCCCCCC		17.44OGP
1330N-linked_GlycosylationRVWQGHANASFCPHG
CCCCCCCCCCCCCCC		30.37UniProtKB CARBOHYD
1529N-linked_GlycosylationLVGCEECNCSGPGIQ
CCCCCCCCCCCCCHH		26.69UniProtKB CARBOHYD
1555N-linked_GlycosylationGQCKCRPNVTGRRCD
CCEEECCCCCCCCCC		25.32UniProtKB CARBOHYD
1606UbiquitinationKENVQGPKCDQCSLG
ECCCCCCCCCCCCCC		58.2129967540
1731PhosphorylationDVFVPMESRPDVVLQ
CEEEECCCCCCEEEE		42.7520068231
1763UbiquitinationHVHRGQLQLVEGNFR
CCCCCEEEEEECCCC		35.2623503661
1800PhosphorylationLQIRALFSQISSAVF
HHHHHHHHHHHHHHH		27.7020860994
1804PhosphorylationALFSQISSAVFLRRV
HHHHHHHHHHHHHHH		30.0420860994
1808UbiquitinationQISSAVFLRRVALEV
HHHHHHHHHHHHHHH		2.4823503661
1854UbiquitinationPGFYRDVKGLFLGRC
CCCHHCCCCEECCCE		54.9433845483
1940UbiquitinationGRTQCLCKPGYAGAS
CCEEEEECCCCCCCC		28.6433845483
2021O-linked_GlycosylationALLPGNCTRCDCTPC
CCCCCCCCCCCCCCC		38.0328657654
2138O-linked_GlycosylationCNCPPGLSGERCDTC
CCCCCCCCCCCCCCC		44.5228657654
2196N-linked_GlycosylationHEQLRGINASSMAWA
HHHHCCCCHHHHHHH		36.27UniProtKB CARBOHYD
2209N-linked_GlycosylationWARLHRLNASIADLQ
HHHHHHHCCHHHHHH		31.4319159218
2211O-linked_GlycosylationRLHRLNASIADLQSQ
HHHHHCCHHHHHHHH		19.7528657654
2221PhosphorylationDLQSQLRSPLGPRHE
HHHHHHCCCCCCCHH		32.8223312004
2257PhosphorylationLGGQAVGTRDQASQL
HCCCCCCCHHHHHHH		25.19-
2303N-linked_GlycosylationTGHLGLANASAPSGE
CCCCCCCCCCCCCHH		39.2019159218
2305PhosphorylationHLGLANASAPSGEQL
CCCCCCCCCCCHHHH		40.29-
2423N-linked_GlycosylationKQELSRDNATLQATL
HHHHHHHHHHHHHHH		33.4419159218
2425O-linked_GlycosylationELSRDNATLQATLHA
HHHHHHHHHHHHHHH		26.1728657654
2425PhosphorylationELSRDNATLQATLHA
HHHHHHHHHHHHHHH		26.17-
2429PhosphorylationDNATLQATLHAARDT
HHHHHHHHHHHHHHH		13.20-
24512-HydroxyisobutyrylationLHSLDQAKEELERLA
HHCHHHHHHHHHHHH		46.19-
2501N-linked_GlycosylationQLGQLALNLSSIILD
HHHHHHHHHHHHHEE		32.0619159218
2503PhosphorylationGQLALNLSSIILDVN
HHHHHHHHHHHEECC		20.5827174698
2504PhosphorylationQLALNLSSIILDVNQ
HHHHHHHHHHEECCH		19.4727174698
2515PhosphorylationDVNQDRLTQRAIEAS
ECCHHHHHHHHHHHH		19.5327174698
2568N-linked_GlycosylationRAQQLLANSTALEEA
HHHHHHHCCHHHHHH		39.6019159218
26332-HydroxyisobutyrylationSKKIAHAKAVAAEAQ
HHHHHHHHHHHHHHH		33.26-
2633UbiquitinationSKKIAHAKAVAAEAQ
HHHHHHHHHHHHHHH		33.2629967540
2707N-linked_GlycosylationLENRGVHNASLALSA
HHHCCCCCHHHHHHH		28.9019159218
2709PhosphorylationNRGVHNASLALSASI
HCCCCCHHHHHHHHH		21.3520068231
2713PhosphorylationHNASLALSASIGRVR
CCHHHHHHHHHHHHH		17.8620068231
2715PhosphorylationASLALSASIGRVREL
HHHHHHHHHHHHHHH		23.3820068231
2759PhosphorylationDLADLAAYTALKFYL
HHHHHHHHHHHHHHH		6.2221406692
2760PhosphorylationLADLAAYTALKFYLQ
HHHHHHHHHHHHHHC		22.3121406692
2784PhosphorylationTEDRFVMYMGSRQAT
CCCEEEEEECCCCCC		7.9420860994
2794PhosphorylationSRQATGDYMGVSLRD
CCCCCCCCCCEECCC		9.3433259812
2798PhosphorylationTGDYMGVSLRDKKVH
CCCCCCEECCCCEEE		16.3830576142
2918PhosphorylationSLYNFERTFQLDTAV
HHHCCCCEEECCCCC		14.4520860994
2944PhosphorylationDPWLTDGSYLDGTGF
CCCCCCCCCCCCCCE		25.90-
2955PhosphorylationGTGFARISFDSQIST
CCCEEEEEECCCCCC		19.9024275569
2958PhosphorylationFARISFDSQISTTKR
EEEEEECCCCCCCHH		27.6624275569
2961PhosphorylationISFDSQISTTKRFEQ
EEECCCCCCCHHHHH		23.5324275569
2962PhosphorylationSFDSQISTTKRFEQE
EECCCCCCCHHHHHH		37.6624275569
2963PhosphorylationFDSQISTTKRFEQEL
ECCCCCCCHHHHHHH		17.2724275569
2986PhosphorylationLFFLKQQSQFLCLAV
HHHHHHCCCEEEEEE		22.0224043423
2997PhosphorylationCLAVQEGSLVLLYDF
EEEECCCCEEEEEEC		17.9824043423
3002PhosphorylationEGSLVLLYDFGAGLK
CCCEEEEEECCCCCC		12.6924043423
3035PhosphorylationQVFLLGGSRKRVLVR
EEEECCCCCCEEEEE		32.60-
3049PhosphorylationRVERATVYSVEQDND
EEEEEEEEEEECCCC		11.57-
3100PhosphorylationGIKALGKYVDLKRLN
HHHHHHCEEEHHHCC		9.4428355574
3107N-linked_GlycosylationYVDLKRLNTTGVSAG
EEEHHHCCCCCCCCC		39.3619159218
3108PhosphorylationVDLKRLNTTGVSAGC
EEHHHCCCCCCCCCC		29.5319690332
3209N-linked_GlycosylationHYVAFYSNATGVWLY
EEEEEEECCCEEEEE		30.09UniProtKB CARBOHYD
3257N-linked_GlycosylationPESGTIYNFSGCISN
CCCCCEEECCCHHHH		22.28UniProtKB CARBOHYD
3287N-linked_GlycosylationQQNLGSVNVSTGCAP
HHHCCCCEECCCCHH		24.58UniProtKB CARBOHYD
3365PhosphorylationARHRNWPSLSMHVLP
HHHCCCCCCEEEECC		25.3727732954
3367PhosphorylationHRNWPSLSMHVLPRS
HCCCCCCEEEECCCC		15.9227732954
3391PhosphorylationRLRPGSPSLALFLSN
ECCCCCCCEEEEEEC		28.1524719451
3410PhosphorylationAQMEGLGTRLRAQSR
EEECCHHHHHHHHHC		31.4127762562
3416PhosphorylationGTRLRAQSRQRSRPG
HHHHHHHHCCCCCCC		29.4224719451
3429PhosphorylationPGRWHKVSVRWEKNR
CCCCEEEEEEEECCE		15.6927251275
3466PhosphorylationAEHPQPHTLFVGGLP
CCCCCCCCEEECCCC		28.6822210691
3476PhosphorylationVGGLPASSHSSKLPV
ECCCCCCCCCCCCCE		29.5122210691
3488PhosphorylationLPVTVGFSGCVKRLR
CCEEECCCCCEEHHE		25.9220068231
3626N-linked_GlycosylationLEVDAQSNHTVGPLL
EEECCCCCCCHHHHH		23.83UniProtKB CARBOHYD
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LAMA5_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LAMA5_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LAMA5_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FBLN2_HUMANFBLN2physical
9006922
BCAM_HUMANBCAMphysical
11133776
BCAM_HUMANBCAMphysical
12244066
LAMC1_HUMANLAMC1physical
25241761
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LAMA5_HUMAN

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-2209; ASN-2303; ASN-2423;ASN-2501; ASN-2568; ASN-2707 AND ASN-3107, AND MASS SPECTROMETRY.
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-181 AND TYR-182, ANDMASS SPECTROMETRY.

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