NFASC_MOUSE - dbPTM
NFASC_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NFASC_MOUSE
UniProt AC Q810U3
Protein Name Neurofascin
Gene Name Nfasc
Organism Mus musculus (Mouse).
Sequence Length 1240
Subcellular Localization Cell membrane
Single-pass type I membrane protein.
Protein Description Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions..
Protein Sequence MARQQAPPWVHIALILFLLSLGGAIEIPMDPSIQNELTQPPTITKQSVKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTSSSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSNKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSARNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVAKRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCMASTELDQDLAKAYLTVLADQATPTNRLAALPKGRPDRPRDLELTDLAERSVRLTWIPGDDNNSPITDYVVQFEEDQFQPGVWHDHSRFPGSVNSAVLHLSPYVNYQFRVIAVNEVGSSHPSLPSERYRTSGAPPESNPSDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETRETWNNVTVWGSRYVVGQTPVYVPYEIRVQAENDFGKGPEPDTIIGYSGEDLPSAPRRFRVRQPNLETINLEWDHPEHPNGILIGYILRYVPFNGTKLGKQMVENFSPNQTKFSVQRADPVSRYRFSLSARTQVGSGEAATEESPAPPNEATPTAAPPTLPPTTVGTTGLVSSTDATALAATSEATTVPIIPTVVPTTVATTIATTTTTTAATTTTTTTESPPTTTAGTKIHETAPDEQSIWNVTVLPNSKWANITWKHNFRPGTDFVVEYIDSNHTKKTVPVKAQAQPIQLTDLFPGMTYTLRVYSRDNEGISSTVITFMTSTAYTNNQADIATQGWFIGLMCAIALLVLILLIVCFIKRSRGGKYPVREKKDVPLGPEDPKEEDGSFDYSDEDNKPLQGSQTSLDGTIKQQESDDSLVDYGEGGEGQFNEDGSFIGQYTVKKDKEETEGNESSEATSPVNAIYSLA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
63S-nitrosylationRDNILIECEAKGNPA
CCCEEEEEEECCCCC		4.9624895380
230PhosphorylationIQQKNPFTLKVLTTR
ECCCCCEEEEEEEEC		27.2521454597
235PhosphorylationPFTLKVLTTRGVAER
CEEEEEEEECCCHHC		19.8921454597
305N-linked_GlycosylationNKALRITNVSEEDSG
CCCEEECCCCHHHCC		32.71-
330PhosphorylationGSIRHTISVRVKAAP
CCCEEEEEEEEEECC		12.6729514104
338PhosphorylationVRVKAAPYWLDEPKN
EEEEECCCCCCCCCC		17.5521454597
409N-linked_GlycosylationSRAVYQCNTSNEHGY
CCEEEECCCCCCCCE		30.89-
446N-linked_GlycosylationLIRVILYNRTRLDCP
HHHHHHCCCCCCCCC		35.09-
452S-nitrosylationYNRTRLDCPFFGSPI
CCCCCCCCCCCCCCC		3.6124895380
481PhosphorylationDGGNYHVYENGSLEI
CCCCEEEEECCEEEE		7.14-
483N-linked_GlycosylationGNYHVYENGSLEIKM
CCEEEEECCEEEEEE		27.89-
485PhosphorylationYHVYENGSLEIKMIR
EEEEECCEEEEEEEE		34.12-
501S-nitrosylationEDQGIYTCVATNILG
HHCCEEEEEEHHHCC		0.8024895380
525PhosphorylationVKDPTRIYRMPEDQV
ECCCCCEEECCHHHH		9.5125159016
710PhosphorylationIAVNEVGSSHPSLPS
EEEECCCCCCCCCCC		30.5617203969
711PhosphorylationAVNEVGSSHPSLPSE
EEECCCCCCCCCCCH		33.2217203969
752N-linked_GlycosylationEITWTPMNATSAFGP
EEEEEECCCCCCCCC		41.07-
778N-linked_GlycosylationETRETWNNVTVWGSR
CCCCCCCCEEEECCE		23.54-
866N-linked_GlycosylationILRYVPFNGTKLGKQ
EEECCCCCCCCHHHH		51.67-
881N-linked_GlycosylationMVENFSPNQTKFSVQ
HHHHCCCCCCEEEEE		62.04-
899PhosphorylationPVSRYRFSLSARTQV
CCCEEEEEEEEEEEC		16.6530387612
1160PhosphorylationDPKEEDGSFDYSDED
CCCCCCCCCCCCCCC		27.5419060867
1163PhosphorylationEEDGSFDYSDEDNKP
CCCCCCCCCCCCCCC		18.9321183079
1164PhosphorylationEDGSFDYSDEDNKPL
CCCCCCCCCCCCCCC		36.0519060867
1174PhosphorylationDNKPLQGSQTSLDGT
CCCCCCCCEECCCCC		19.8219060867
1176PhosphorylationKPLQGSQTSLDGTIK
CCCCCCEECCCCCEE		32.7122807455
1177PhosphorylationPLQGSQTSLDGTIKQ
CCCCCEECCCCCEEE		19.4719060867
1187PhosphorylationGTIKQQESDDSLVDY
CCEEECCCCCCCCCC		42.2420415495
1190PhosphorylationKQQESDDSLVDYGEG
EECCCCCCCCCCCCC		34.9720415495
1194PhosphorylationSDDSLVDYGEGGEGQ
CCCCCCCCCCCCCCC		15.0320415495
1207PhosphorylationGQFNEDGSFIGQYTV
CCCCCCCCEEEEEEE		26.4729899451
1213PhosphorylationGSFIGQYTVKKDKEE
CCEEEEEEEECCHHH		20.26-
1221PhosphorylationVKKDKEETEGNESSE
EECCHHHCCCCCCCC		50.7324925903
1226PhosphorylationEETEGNESSEATSPV
HHCCCCCCCCCCCHH		37.1624925903
1227PhosphorylationETEGNESSEATSPVN
HCCCCCCCCCCCHHH		25.6824925903
1230PhosphorylationGNESSEATSPVNAIY
CCCCCCCCCHHHHHH		29.5225521595
1231PhosphorylationNESSEATSPVNAIYS
CCCCCCCCHHHHHHC		33.6225521595
1237PhosphorylationTSPVNAIYSLA----
CCHHHHHHCCC----		8.6724925903
1238PhosphorylationSPVNAIYSLA-----
CHHHHHHCCC-----		16.2320047950
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NFASC_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NFASC_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NFASC_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of NFASC_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NFASC_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Proteomic analysis of in vivo phosphorylated synaptic proteins.";
Collins M.O., Yu L., Coba M.P., Husi H., Campuzano I.,Blackstock W.P., Choudhary J.S., Grant S.G.;
J. Biol. Chem. 280:5972-5982(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1226 AND SER-1227, ANDMASS SPECTROMETRY.

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