HCN1_MOUSE - dbPTM
HCN1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HCN1_MOUSE
UniProt AC O88704
Protein Name Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Gene Name Hcn1
Organism Mus musculus (Mouse).
Sequence Length 910
Subcellular Localization Cell membrane
Multi-pass membrane protein .
Protein Description Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli..
Protein Sequence MEGGGKPNSASNSRDDGNSVFPSKAPATGPVAADKRLGTPPGGGAAGKEHGNSVCFKVDGGGGEEPAGSFEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILSELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQAIPPINYPQMTALNCTSSTTTPTSRMRTQSPPVYTATSLSHSNLHSPSPSTQTPQPSAILSPCSYTTAVCSPPIQSPLATRTFHYASPTASQLSLMQQPQQQLPQSQVQQTQTQTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPQTPGSSTPKNEVHKSTQALHNTNLTKEVRPLSASQPSLPHEVSTLISRPHPTVGESLASIPQPVAAVHSTGLQAGSRSTVPQRVTLFRQMSSGAIPPNRGVPPAPPPPAAVQRESPSVLNTDPDAEKPRFASNL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
24UbiquitinationGNSVFPSKAPATGPV
CCCCCCCCCCCCCCC		59.6427667366
35UbiquitinationTGPVAADKRLGTPPG
CCCCCCCCCCCCCCC		44.8127667366
39PhosphorylationAADKRLGTPPGGGAA
CCCCCCCCCCCCCCC		30.7925521595
53PhosphorylationAGKEHGNSVCFKVDG
CCCCCCCEEEEEECC		25.5129899451
69PhosphorylationGGEEPAGSFEDAEGP
CCCCCCCCCCCCCCH		27.8025521595
88PhosphorylationGFMQRQFTSMLQPGV
HHHHHHHHHHHCCCC		12.6129899451
89PhosphorylationFMQRQFTSMLQPGVN
HHHHHHHHHHCCCCC		20.8429899451
97UbiquitinationMLQPGVNKFSLRMFG
HHCCCCCHHHHHHHC		33.6422790023
99PhosphorylationQPGVNKFSLRMFGSQ
CCCCCHHHHHHHCCH		19.3729899451
107UbiquitinationLRMFGSQKAVEKEQE
HHHHCCHHHHHHHHH		56.9827667366
327N-linked_GlycosylationVSLNEMVNDSWGKQY
EEHHHHHCCCCHHHH		35.979405696
406PhosphorylationKYKQVEQYMSFHKLP
HHHHHHHHHHHCCCC		4.92-
419UbiquitinationLPADMRQKIHDYYEH
CCHHHHHHHHHHHHH		31.4822790023
461PhosphorylationNCRKLVATMPLFANA
CCCHHHHHCCCCCCC		16.3127180971
474PhosphorylationNADPNFVTAMLSKLR
CCCHHHHHHHHHHCC		11.3827180971
478PhosphorylationNFVTAMLSKLRFEVF
HHHHHHHHHCCCEEE		19.2927180971
502PhosphorylationGAVGKKMYFIQHGVA
CCCCCEEEEEECCCE		13.3529895711
513PhosphorylationHGVAGVITKSSKEMK
CCCEEEEECCCCCEE		23.5929895711
515PhosphorylationVAGVITKSSKEMKLT
CEEEEECCCCCEECC		37.6829895711
516PhosphorylationAGVITKSSKEMKLTD
EEEEECCCCCEECCC		33.9029895711
522PhosphorylationSSKEMKLTDGSYFGE
CCCCEECCCCCEEEE		32.5629895711
525PhosphorylationEMKLTDGSYFGEICL
CEECCCCCEEEEEEE		21.7929895711
534PhosphorylationFGEICLLTKGRRTAS
EEEEEEEECCCCCEE		20.6429895711
535UbiquitinationGEICLLTKGRRTASV
EEEEEEECCCCCEEE		50.8422790023
586UbiquitinationRLDRIGKKNSILLQK
HHHHHCCCCHHHHHH		51.1922790023
588PhosphorylationDRIGKKNSILLQKFQ
HHHCCCCHHHHHHHH		24.4029899451
593UbiquitinationKNSILLQKFQKDLNT
CCHHHHHHHHHHHCC		50.1322790023
596UbiquitinationILLQKFQKDLNTGVF
HHHHHHHHHHCCCCC		68.2822790023
612UbiquitinationNQENEILKQIVKHDR
CHHHHHHHHHHHCCH		43.5722790023
791PhosphorylationPKNEVHKSTQALHNT
CHHHHHHHHHHHHHC		15.7529899451
792PhosphorylationKNEVHKSTQALHNTN
HHHHHHHHHHHHHCC		23.7529899451
867PhosphorylationVTLFRQMSSGAIPPN
EEHHHHHCCCCCCCC		19.7922324799
868PhosphorylationTLFRQMSSGAIPPNR
EHHHHHCCCCCCCCC		27.2322324799
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HCN1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HCN1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HCN1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PEX5R_MOUSEPex5lphysical
15564593
ARHG7_MOUSEArhgef7physical
28671696
ASIC1_MOUSEAsic1physical
28671696
BSN_MOUSEBsnphysical
28671696
KCC2A_MOUSECamk2aphysical
28671696
KCC2B_MOUSECamk2bphysical
28671696
CTRO_MOUSECitphysical
28671696
CN37_MOUSECnpphysical
28671696
CSK21_MOUSECsnk2a1physical
28671696
DLG1_MOUSEDlg1physical
28671696
DSCAM_MOUSEDscamphysical
28671696
GABR2_MOUSEGabbr2physical
28671696
GIT1_MOUSEGit1physical
28671696
GEPH_MOUSEGphnphysical
28671696
GSK3B_MOUSEGsk3bphysical
28671696
HCN2_MOUSEHcn2physical
28671696
KCD12_MOUSEKctd12physical
28671696
KCD16_MOUSEKctd16physical
28671696
JIP1_MOUSEMapk8ip1physical
28671696
JIP2_MOUSEMapk8ip2physical
28671696
JIP3_MOUSEMapk8ip3physical
28671696
MPDZ_MOUSEMpdzphysical
28671696
NF1_MOUSENf1physical
28671696
PAK3_MOUSEPak3physical
28671696
PEX5R_MOUSEPex5lphysical
28671696
KAP0_MOUSEPrkar1aphysical
28671696
KAP1_MOUSEPrkar1bphysical
28671696
RAB3I_MOUSERab3ipphysical
28671696
RP3A_MOUSERph3aphysical
28671696
SH319_MOUSESh3d19physical
28671696
SH3K1_MOUSESh3kbp1physical
28671696
SHAN3_MOUSEShank3physical
28671696
SHRM3_MOUSEShroom3physical
28671696
SPKAP_MOUSESphkapphysical
28671696
SPTB2_MOUSESptbn1physical
28671696
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HCN1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-39 AND SER-69, AND MASSSPECTROMETRY.

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