JIP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: JIP2_MOUSE
• UniProt AC: Q9ERE9
• Protein Name: C-Jun-amino-terminal kinase-interacting protein 2
• Gene Name: Mapk8ip2
• Organism: Mus musculus (Mouse).
• Sequence Length: 830
• Subcellular Localization: Cytoplasm. Accumulates in cell surface projections..
• Protein Description: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells (By similarity)..
• Protein Sequence: MADRAEMFSLSTFHSLSPPGCRPPQDISLEEFDDEDLSEITDDCGLGLSYDSDHCEKDSLSLGRSEQPHPICSFQDDFQEFEMIDDNEEEDDEEEEEEEEEEEDGDRQGKAGGGPGSQALAGDSLIPSPSLEESHKLRPTTLHLTTLGAQDSLNNNNGGFTSAPPSSWQETVLRSPAQEPLKELPAPLLPAEEERHEVQSLARPGCDCEGNQPPEPPASSGGASPSSDPGIEADLRSHSSGGHEGRRSSQELSSPGSDSEDAGGARLGRMISSISETELELSSDGGSSSGRSSHLTNSIEEASSPASEPEPEPEPLHEPPRRPAFLPVGQDDTNSEYESGSESEPDLSEDADSPWLLSNLVSRMISEGSSPIRCPGQCLSPAPRLPEEAASQANSVPQDCQDPEAGPHVELVDMDTLCGPPPPAPAAPRLGPAQPGPCLFLSNPTRDTITPLWATPGRTARPGRSCSAACSEEEEEDEEEDEEDEEDAEDSVVPPGSRTTGSTAPLDASLVYDAVKYTLVVDEHTQLELVSLRRCAGLGNDSEEDSSCEASEEEAGATLLGSDQVPEDASPDSPDLTFSKKFLNVFVNSTSRSSSTESFGLFSCVVNGEEREQTHRAVFRFIPRHPDELELDVDDPVLVEAEEDDFWFRGFNMRTGERGVFPAFYAHAVPGPAKDLLGSKRSPCWVDRFDVQFLGSVEVPCHQGNGILCAAMQKIATARKLTVHLRPPASCDLEISLRGVKLSLSGGGPEFQRCSHFFQMKNISFCGCHPRNSCYFGFITKHPLLSRFACHVFVSQESMRPVARSVGRAFLEYYQEHLAFACPTEDIYLE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
117	Phosphorylation	KAGGGPGSQALAGDS CCCCCCCHHCCCCCC	18.53	30372032
124	Phosphorylation	SQALAGDSLIPSPSL HHCCCCCCCCCCCCH	27.55	20415495
128	Phosphorylation	AGDSLIPSPSLEESH CCCCCCCCCCHHHHH	21.81	25521595
130	Phosphorylation	DSLIPSPSLEESHKL CCCCCCCCHHHHHCC	53.39	28066266
134	Phosphorylation	PSPSLEESHKLRPTT CCCCHHHHHCCCCCE	19.29	28066266
175	Phosphorylation	WQETVLRSPAQEPLK HHHHHHCCCCCCCHH	22.04	28066266
248	Phosphorylation	GGHEGRRSSQELSSP CCCCCCCCCCCCCCC	34.70	25521595
249	Phosphorylation	GHEGRRSSQELSSPG CCCCCCCCCCCCCCC	26.34	25521595
253	Phosphorylation	RRSSQELSSPGSDSE CCCCCCCCCCCCCCC	33.46	24759943
254	Phosphorylation	RSSQELSSPGSDSED CCCCCCCCCCCCCCC	46.00	24759943
257	Phosphorylation	QELSSPGSDSEDAGG CCCCCCCCCCCCCHH	41.15	25521595
259	Phosphorylation	LSSPGSDSEDAGGAR CCCCCCCCCCCHHHH	38.79	24759943
272	Phosphorylation	ARLGRMISSISETEL HHHHHHHHCCCEEEE	16.57	29899451
304	Phosphorylation	NSIEEASSPASEPEP CCHHHHCCCCCCCCC	31.37	22817900
307	Phosphorylation	EEASSPASEPEPEPE HHHCCCCCCCCCCCC	58.00	22817900
366	Phosphorylation	NLVSRMISEGSSPIR HHHHHHHHCCCCCCC	26.93	22817900
369	Phosphorylation	SRMISEGSSPIRCPG HHHHHCCCCCCCCCC	28.96	29899451
370	Phosphorylation	RMISEGSSPIRCPGQ HHHHCCCCCCCCCCC	34.89	22817900
380	Phosphorylation	RCPGQCLSPAPRLPE CCCCCCCCCCCCCCH	27.00	28066266
455	Phosphorylation	TITPLWATPGRTARP CCCCCCCCCCCCCCC	18.07	28066266
465	Phosphorylation	RTARPGRSCSAACSE CCCCCCCCCCCCCCC	20.52	29899451
471	Phosphorylation	RSCSAACSEEEEEDE CCCCCCCCCCHHHCH	43.23	29899451
581	Ubiquitination	PDLTFSKKFLNVFVN CCCCCCHHHHHEECC	54.61	-
589	Phosphorylation	FLNVFVNSTSRSSST HHHEECCCCCCCCCC	23.58	22817900
590	Phosphorylation	LNVFVNSTSRSSSTE HHEECCCCCCCCCCC	23.97	21183079
591	Phosphorylation	NVFVNSTSRSSSTES HEECCCCCCCCCCCE	29.95	20415495

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of JIP2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of JIP2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of JIP2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
JIP3_MOUSE	Mapk8ip3	physical	10629060

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.