SPKAP_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPKAP_MOUSE
• UniProt AC: Q6NSW3
• Protein Name: A-kinase anchor protein SPHKAP
• Gene Name: Sphkap
• Organism: Mus musculus (Mouse).
• Sequence Length: 1687
• Subcellular Localization: Cytoplasm. Colocalizes with SPHK1 in the cytoplasm..
• Protein Description: Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1 (By similarity)..
• Protein Sequence: MDVNSRLSVQSNVESPLMHEGPEPQQITSSAAGNLAGSITACKKVLRSNSLLESTDYWLQNQRTPCQIGFVEDESENCASVCFVNLDVNKDACITENLQQKLVNVSPDLPNLISSMNVQQPKENEIVLLSGLASGNPQADFDVSQCPWLPDICLVQCARGNRPNSTNCIIFEINKFLIGLEVVQERQLHLETNVLKLEDDTNCSLSSIEEDFLTASEHLEEEIEVDDCRSGLENTNVSANVLESKKPKETTQEGWDYHKEKLHCALGEKHIRKHRTPSTKTEGSKENTEENTSLKSLNRLVRPSHLKSEVAGNKQLATNYSYPENIKGELETSQMLFIPRDAYLSMVKKDVLSPCSVLSEQGGSHRDHDVTPNPLPPVQNGEASTGEYATNLAESVMQDAFIRLSQSQPTLPQESAVSFSMRSALLPSGCCTKDMVVPRSWNELPKIVIVQSPDGSDTVPEPNVSSWPDMEFVETSGIFSADSSSRPTQSALEVALACAATVIGTISSPQATERFAMEQESLVSTYAQRGTGVQQTQVPQAFMAPSTTEYSFPSALCGMTQVASAVAVCGLCEKEEATCPVAPTDLLPTSGASEEISSIGSLVMERSTELGKEAIAEALLREATLILARPDAYSSLGELLESVNQRIIETTSKTQTLCTESVQRNELAHTLSNVILKHSVDELHQKTTMAHPTDERHPCGTLDTLMESVNQLLHNVICFTFKKMNHIVTLSEHPSFDQAAGQAWVKAFACPSSQPLSNAHGTGLVIRNLVEDASPKSNKGGARPELVNNPRLQSEFSCSHRMFDSTAKSFPKEIYLKGIMGEDTRNPHHTLNYDSNERRASTDLGKLTTASEGCSGFQETEDSIVPNTQEKYICATPLNNEAQVNLSLLGDDLSVPAQSTLEAKQSEVYGITDFAEELAETVVSMATEIAAICLDNSNGKQPWFCAWKRGNEFLTAPNGSCRSLKRKKENSSAGSTVRKHKPPRLSEIKRKADEHPELKEKLMNRVMDESMNLEDIPDSVSTFANEVAAKIMNLTEFSMVDGVWQGQSCSRTRLLGGDRWNRLKASSCESIPEEDSEARVFVNSLGLMSTLSQPVSRASSVSKQSSCESITDEFSRFMVKQMENEGRGFELLLDYYAGKNASSIMSSAMQQACQKNDHLNVRPSCPSKQSSTESITEEFYRYMLRDIAKESKDGASSRRSSHDWTTGLLSPSTRSPLCYRQSSMPDSRSPCSRLTVNAPVKANSLDGFAQNCPQDSVNVQPVSRASSSGLCKSDSCLYRRSGTDQITNMLIHETWASSIEALMRKNKIIADDSEAANASPGPVSSGSPLQVEKNANRLATSKGHRGPTLLVQESVDYQRKDAVTEGNHSPVSSPGKTAPVKKPSDFDPRRETSACHNAAGLNSPRRSLCSRDVPLIQIETDQKEECIGEPGPFLSQSGSLEETEGHQPEETIPDVARNEDTAPSTCQSSRDSLETSGEVEVEVLKEDIPRDESRNPPSSSEESTGSWSQLANEEDIPDDTSSFLQLSERSMSNGNSSGTSSLGIMDLDIYQESIPSSPMINELVEEKEILKEQSESIKEHASGLPGRAASPQRSLLVINFDLEPECPDAELRATLQWIAASELGIPTIYFKKSQESRIEKFLDVVKLVQQKSWKVGDIFHAVVQYCKLHAEQKERTPSLFDWLLELG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23 (in isoform 4)	Phosphorylation	-	67.60	21183079
23 (in isoform 3)	Phosphorylation	-	67.60	21183079
40 (in isoform 4)	Phosphorylation	-	27.92	21183079
40 (in isoform 3)	Phosphorylation	-	27.92	21183079
40	Phosphorylation	GNLAGSITACKKVLR CHHHHHHHHHHHHHH	27.92	21183079
48	Phosphorylation	ACKKVLRSNSLLEST HHHHHHHHCCHHHCC	26.98	25521595
50	Phosphorylation	KKVLRSNSLLESTDY HHHHHHCCHHHCCHH	35.26	24925903
54	Phosphorylation	RSNSLLESTDYWLQN HHCCHHHCCHHHHHC	26.92	24759943
65 (in isoform 4)	Phosphorylation	-	15.37	21183079
65 (in isoform 3)	Phosphorylation	-	15.37	21183079
75	Phosphorylation	IGFVEDESENCASVC EEECCCCCCCEEEEE	46.56	22807455
405	O-linked_Glycosylation	QDAFIRLSQSQPTLP HHHHHHHHCCCCCCC	20.24	55414033
407	Phosphorylation	AFIRLSQSQPTLPQE HHHHHHCCCCCCCHH	34.45	26239621
415	Phosphorylation	QPTLPQESAVSFSMR CCCCCHHHHCCHHHH	28.82	26239621
420	Phosphorylation	QESAVSFSMRSALLP HHHHCCHHHHHHHCC	13.04	28059163
731	Phosphorylation	MNHIVTLSEHPSFDQ CCEEEEECCCCCHHH	25.21	22324799
735	Phosphorylation	VTLSEHPSFDQAAGQ EEECCCCCHHHHHHH	43.28	22324799
752	Phosphorylation	VKAFACPSSQPLSNA HHHEECCCCCCCCCC	41.30	26160508
753	Phosphorylation	KAFACPSSQPLSNAH HHEECCCCCCCCCCC	22.44	26160508
757	Phosphorylation	CPSSQPLSNAHGTGL CCCCCCCCCCCCCCE	38.36	26160508
762	Phosphorylation	PLSNAHGTGLVIRNL CCCCCCCCCEEEECH	19.92	26160508
774	Phosphorylation	RNLVEDASPKSNKGG ECHHHCCCCCCCCCC	45.22	27841257
841	Phosphorylation	DSNERRASTDLGKLT CCCCCCCCCCHHHHC	22.20	22324799
842	Phosphorylation	SNERRASTDLGKLTT CCCCCCCCCHHHHCC	33.97	22324799
960	Phosphorylation	FLTAPNGSCRSLKRK EEECCCCCHHHCCCC	17.01	29899451
971	Phosphorylation	LKRKKENSSAGSTVR CCCCCCCCCCCCHHH	23.74	29899451
975	Phosphorylation	KENSSAGSTVRKHKP CCCCCCCCHHHHCCC	24.36	27841257
1010	Phosphorylation	MNRVMDESMNLEDIP HHHHHCCCCCHHHCC	14.54	19060867
1035	Phosphorylation	AAKIMNLTEFSMVDG HHHHCCCCCCEECCC	29.94	22807455
1066	Phosphorylation	RWNRLKASSCESIPE HHHHHCHHHCCCCCC	33.65	21183079
1067	Phosphorylation	WNRLKASSCESIPEE HHHHCHHHCCCCCCH	27.11	25521595
1070	Phosphorylation	LKASSCESIPEEDSE HCHHHCCCCCCHHCC	48.01	25521595
1084	Phosphorylation	EARVFVNSLGLMSTL CHHHHHHHHHHHHHH	20.65	28285833
1089	Phosphorylation	VNSLGLMSTLSQPVS HHHHHHHHHHCCCCH	31.10	21183079
1090	Phosphorylation	NSLGLMSTLSQPVSR HHHHHHHHHCCCCHH	19.23	19060867
1092	Phosphorylation	LGLMSTLSQPVSRAS HHHHHHHCCCCHHHH	32.31	25162660
1096	Phosphorylation	STLSQPVSRASSVSK HHHCCCCHHHHCCCC	28.89	24759943
1096	O-linked_Glycosylation	STLSQPVSRASSVSK HHHCCCCHHHHCCCC	28.89	55414039
1099	Phosphorylation	SQPVSRASSVSKQSS CCCCHHHHCCCCHHC	30.11	24759943
1100	Phosphorylation	QPVSRASSVSKQSSC CCCHHHHCCCCHHCC	29.44	29899451
1102	Phosphorylation	VSRASSVSKQSSCES CHHHHCCCCHHCCHH	27.25	29899451
1105	Phosphorylation	ASSVSKQSSCESITD HHCCCCHHCCHHHHH	40.47	22324799
1106	Phosphorylation	SSVSKQSSCESITDE HCCCCHHCCHHHHHH	21.29	22324799
1109	Phosphorylation	SKQSSCESITDEFSR CCHHCCHHHHHHHHH	34.81	25521595
1111	Phosphorylation	QSSCESITDEFSRFM HHCCHHHHHHHHHHH	38.46	25521595
1115	Phosphorylation	ESITDEFSRFMVKQM HHHHHHHHHHHHHHH	23.66	22324799
1167	Phosphorylation	NVRPSCPSKQSSTES CCCCCCCCCCCCCCC	47.88	-
1170	Phosphorylation	PSCPSKQSSTESITE CCCCCCCCCCCCHHH	42.85	29899451
1171	Phosphorylation	SCPSKQSSTESITEE CCCCCCCCCCCHHHH	33.43	25521595
1172	Phosphorylation	CPSKQSSTESITEEF CCCCCCCCCCHHHHH	38.71	29899451
1174	Phosphorylation	SKQSSTESITEEFYR CCCCCCCCHHHHHHH	34.59	22807455
1176	Phosphorylation	QSSTESITEEFYRYM CCCCCCHHHHHHHHH	38.45	29899451
1189	Acetylation	YMLRDIAKESKDGAS HHHHHHHHHCCCCCC	63.96	7719009
1196	Phosphorylation	KESKDGASSRRSSHD HHCCCCCCCCCCCCC	29.88	29899451
1197	Phosphorylation	ESKDGASSRRSSHDW HCCCCCCCCCCCCCC	31.04	29899451
1200	Phosphorylation	DGASSRRSSHDWTTG CCCCCCCCCCCCCCC	30.80	19060867
1201	Phosphorylation	GASSRRSSHDWTTGL CCCCCCCCCCCCCCC	24.53	19060867
1223	Phosphorylation	PLCYRQSSMPDSRSP CCHHCCCCCCCCCCC	26.46	25521595
1235	Phosphorylation	RSPCSRLTVNAPVKA CCCCCCCEECCCCCC	15.59	24759943
1244	Phosphorylation	NAPVKANSLDGFAQN CCCCCCCCCCHHHHC	32.47	25521595
1263	O-linked_Glycosylation	SVNVQPVSRASSSGL CCCCEECCCCCCCCC	28.89	55414045
1263	Phosphorylation	SVNVQPVSRASSSGL CCCCEECCCCCCCCC	28.89	22871156
1266	Phosphorylation	VQPVSRASSSGLCKS CEECCCCCCCCCCCC	24.75	29899451
1273	Phosphorylation	SSSGLCKSDSCLYRR CCCCCCCCCCCEECC	33.49	25521595
1280	Methylation	SDSCLYRRSGTDQIT CCCCEECCCCCHHHH	26.36	58859693
1298	Phosphorylation	IHETWASSIEALMRK HHHHHHHHHHHHHHC	19.39	22807455
1307 (in isoform 3)	Ubiquitination	-	38.23	22790023
1307	Ubiquitination	EALMRKNKIIADDSE HHHHHCCCEECCCHH	38.23	22790023
1319	Phosphorylation	DSEAANASPGPVSSG CHHHHCCCCCCCCCC	30.14	24759943
1324	Phosphorylation	NASPGPVSSGSPLQV CCCCCCCCCCCCCEE	31.92	25293948
1325	Phosphorylation	ASPGPVSSGSPLQVE CCCCCCCCCCCCEEC	43.45	24759943
1327	Phosphorylation	PGPVSSGSPLQVEKN CCCCCCCCCCEECCC	25.12	27841257
1332 (in isoform 3)	Ubiquitination	-	27.86	-
1348	Phosphorylation	SKGHRGPTLLVQESV CCCCCCCEEEEEECC	35.23	28059163
1354	Phosphorylation	PTLLVQESVDYQRKD CEEEEEECCCCHHCC	11.82	29899451
1360	Acetylation	ESVDYQRKDAVTEGN ECCCCHHCCCCCCCC	34.22	7719019
1364	Phosphorylation	YQRKDAVTEGNHSPV CHHCCCCCCCCCCCC	39.64	29899451
1369	Phosphorylation	AVTEGNHSPVSSPGK CCCCCCCCCCCCCCC	30.88	25521595
1372	Phosphorylation	EGNHSPVSSPGKTAP CCCCCCCCCCCCCCC	33.91	21183079
1373	Phosphorylation	GNHSPVSSPGKTAPV CCCCCCCCCCCCCCC	37.60	19060867
1377	Phosphorylation	PVSSPGKTAPVKKPS CCCCCCCCCCCCCCC	41.95	21183079
1403	Phosphorylation	HNAAGLNSPRRSLCS HHCCCCCCCCHHHHC	25.48	29899451
1437	Phosphorylation	PGPFLSQSGSLEETE CCCCCCCCCCCCCCC	27.29	25521595
1439	Phosphorylation	PFLSQSGSLEETEGH CCCCCCCCCCCCCCC	37.54	25521595
1464	Phosphorylation	RNEDTAPSTCQSSRD CCCCCCCCCCCCCHH	39.07	22871156
1465	Phosphorylation	NEDTAPSTCQSSRDS CCCCCCCCCCCCHHH	17.32	22871156
1499	Phosphorylation	ESRNPPSSSEESTGS CCCCCCCCCCCCCCC	47.76	-
1530 (in isoform 2)	Phosphorylation	-	23.63	27841257
1532 (in isoform 2)	Phosphorylation	-	42.72	25162660
1574	Phosphorylation	KEILKEQSESIKEHA HHHHHHHHHHHHHHH	34.11	20415495
1576	Phosphorylation	ILKEQSESIKEHASG HHHHHHHHHHHHHCC	44.18	20415495
1666	S-palmitoylation	FHAVVQYCKLHAEQK HHHHHHHHHHHHHHH	1.80	28680068

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPKAP_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPKAP_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPKAP_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SPKAP_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.