KAP1_MOUSE - dbPTM
KAP1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KAP1_MOUSE
UniProt AC P12849
Protein Name cAMP-dependent protein kinase type I-beta regulatory subunit
Gene Name Prkar1b
Organism Mus musculus (Mouse).
Sequence Length 381
Subcellular Localization Cell membrane.
Protein Description Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells..
Protein Sequence MASPSCFHSEDEDSLKGCEMYVQKHGIQQVLKECIVHLCVAKPDRPLRFLREHFEKLEKEENRQILARQKSNSQCDSHDEEISPTPPNPVVKARRRRGGVSAEVYTEEDAVSYVRKVIPKDYKTMTALAKAISKNVLFSHLDDNERSDIFDAMFPVTHIGGETVIQQGNEGDNFYVIDQGEVDVYVNGEWVTNISEGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVKLDRPRFERVLGPCSEILKRNIQRYNSFISLTV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MASPSCFHSE
-----CCCCCCCCCC		18.9526824392
5Phosphorylation---MASPSCFHSEDE
---CCCCCCCCCCCC		27.2428066266
9PhosphorylationASPSCFHSEDEDSLK
CCCCCCCCCCCCCCC		26.8722817900
21NitrationSLKGCEMYVQKHGIQ
CCCCHHHHHHHCCHH		4.21-
21Nitrated tyrosineSLKGCEMYVQKHGIQ
CCCCHHHHHHHCCHH		4.21-
56AcetylationFLREHFEKLEKEENR
HHHHHHHHHHHHHHH		62.0923576753
71PhosphorylationQILARQKSNSQCDSH
HHHHHHHCCCCCCCC		33.1225521595
73PhosphorylationLARQKSNSQCDSHDE
HHHHHCCCCCCCCCC		39.0025521595
77PhosphorylationKSNSQCDSHDEEISP
HCCCCCCCCCCCCCC		40.2325521595
83PhosphorylationDSHDEEISPTPPNPV
CCCCCCCCCCCCCHH		26.4625521595
85PhosphorylationHDEEISPTPPNPVVK
CCCCCCCCCCCHHHH		44.5824925903
92UbiquitinationTPPNPVVKARRRRGG
CCCCHHHHHHHHCCC		36.0922790023
97MethylationVVKARRRRGGVSAEV
HHHHHHHCCCCCEEE		44.3924129315
134AcetylationALAKAISKNVLFSHL
HHHHHHHHCCCCCCC		44.9919851983
218UbiquitinationRAATVKAKTDLKLWG
CCCEEEECCCCEECC		36.53-
222UbiquitinationVKAKTDLKLWGIDRD
EEECCCCEECCCCHH		45.0322790023
244UbiquitinationGSTLRKRKMYEEFLS
CHHHHHHHHHHHHHH		49.20-
251PhosphorylationKMYEEFLSKVSILES
HHHHHHHHHHHHHHH		36.0118779572
252UbiquitinationMYEEFLSKVSILESL
HHHHHHHHHHHHHHH		41.9922790023
261UbiquitinationSILESLEKWERLTVA
HHHHHHHHHHCCCHH		60.7022790023
307PhosphorylationASVLQRRSPNEEYVE
HHHHCCCCCCCCCEE		33.9829899451
312PhosphorylationRRSPNEEYVEVGRLG
CCCCCCCCEEECCCC		8.8425521595
338PhosphorylationLNRPRAATVVARGPL
HCCCCCEEEEECCCE		17.96-
346UbiquitinationVVARGPLKCVKLDRP
EEECCCEEEEECCCH		39.86-
349UbiquitinationRGPLKCVKLDRPRFE
CCCEEEEECCCHHHH		54.89-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KAP1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KAP1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KAP1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of KAP1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KAP1_MOUSE

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Related Literatures of Post-Translational Modification

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