RP3A_MOUSE - dbPTM
RP3A_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RP3A_MOUSE
UniProt AC P47708
Protein Name Rabphilin-3A
Gene Name Rph3a
Organism Mus musculus (Mouse).
Sequence Length 681
Subcellular Localization Cell junction, synapse. Membrane
Peripheral membrane protein .
Protein Description Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal..
Protein Sequence MTDTVVNRWMYPGDGPLQSNDKEQLQAGWSVHPGAQTDRQRKQEELTDEEKEIINRVIARAEKMEAMEQERIGRLVDRLETMRKNVAGDGVNRCILCGEQLGMLGSACVVCEDCKKNVCTKCGVETSNNRPHPVWLCKICLEQREVWKRSGAWFFKGFPKQVLPQPMPIKKTKPQQPAGEPATQEQPTPESRHPARAPARGDMEDRRPPGQKPGPDLTSAPGRGSHGPPTRRASEARMSTAARDSEGWDHAHGGGTGDTSRSPAGLRRANSVQAARPAPAPVPSPAPPQPVQPGPPGGSRATPGPGRFPEQSTEAPPSDPGYPGAVAPAREERTGPAGGFQAAPHTAAPYSQAAPARQPPPAEEEEEEANSYDSDEATTLGALEFSLLYDQDNSNLQCTIIRAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPVWNETLQYHGITEEDMQRKTLRISVCDEDKFGHNEFIGETRFSLKKLKANQRKNFNICLERVIPMKRAGTTGSARGMALYEEEQVERIGDIEERGKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISAKGERLKHWYECLKNKDKKIERWHQLQNENHVSSD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
47PhosphorylationQRKQEELTDEEKEII
HHHHHHCCHHHHHHH		44.6529899451
80UbiquitinationGRLVDRLETMRKNVA
HHHHHHHHHHHHHHC		41.2627667366
84UbiquitinationDRLETMRKNVAGDGV
HHHHHHHHHHCCCCC		44.9727667366
137S-palmitoylationRPHPVWLCKICLEQR
CCCCEEEEHHHHHHH		1.3128680068
169UbiquitinationVLPQPMPIKKTKPQQ
CCCCCCCCCCCCCCC		6.0927667366
173UbiquitinationPMPIKKTKPQQPAGE
CCCCCCCCCCCCCCC		50.1127667366
188PhosphorylationPATQEQPTPESRHPA
CCCCCCCCCCCCCCC		39.1125521595
223MethylationDLTSAPGRGSHGPPT
CCCCCCCCCCCCCCC		42.2424129315
234PhosphorylationGPPTRRASEARMSTA
CCCCCCHHHHHHHHH		29.9411466418
239PhosphorylationRASEARMSTAARDSE
CHHHHHHHHHCCCCC		14.8929899451
245PhosphorylationMSTAARDSEGWDHAH
HHHHCCCCCCCCCCC		32.2429899451
256PhosphorylationDHAHGGGTGDTSRSP
CCCCCCCCCCCCCCH		34.8522817900
259PhosphorylationHGGGTGDTSRSPAGL
CCCCCCCCCCCHHHH		27.6429899451
260PhosphorylationGGGTGDTSRSPAGLR
CCCCCCCCCCHHHHH		35.1929899451
262PhosphorylationGTGDTSRSPAGLRRA
CCCCCCCCHHHHHHC		20.9019060867
271PhosphorylationAGLRRANSVQAARPA
HHHHHCCCCCCCCCC		18.0225521595
312PhosphorylationPGRFPEQSTEAPPSD
CCCCCCCCCCCCCCC		26.9329899451
346O-linked_GlycosylationGFQAAPHTAAPYSQA
CCCCCCCCCCCCCCC		24.3755413507
351O-linked_GlycosylationPHTAAPYSQAAPARQ
CCCCCCCCCCCCCCC		16.5746273759
379PhosphorylationYDSDEATTLGALEFS
CCCHHHHHHHHHEEE		30.1829899451
411PhosphorylationKGLKPMDSNGLADPY
CCCCCCCCCCCCCCE		26.9225521595
428PhosphorylationLHLLPGASKSNKLRT
EEECCCCCCCCCCCC		42.4022817900
464PhosphorylationEEDMQRKTLRISVCD
HHHHHHCEEEEEECC		24.37-
468PhosphorylationQRKTLRISVCDEDKF
HHCEEEEEECCCCCC		15.40-
484PhosphorylationHNEFIGETRFSLKKL
CCCCCCCHHHCHHHH		31.6229899451
641S-nitrosylationSNDYIGGCQLGISAK
CCCCCCCCEEECCCC		2.2622588120
660UbiquitinationKHWYECLKNKDKKIE
HHHHHHHHCCCHHHH		73.8722790023
679PhosphorylationLQNENHVSSD-----
HHHCCCCCCC-----		22.6524925903
680PhosphorylationQNENHVSSD------
HHCCCCCCC------		46.3725521595
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
234SPhosphorylationKinasePKN1P70268
PSP
271SPhosphorylationKinasePKN1P70268
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RP3A_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RP3A_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RAB3A_MOUSERab3aphysical
12578829
RAB8A_MOUSERab8aphysical
12578829
RB27A_MOUSERab27aphysical
12578829
RAB3B_MOUSERab3bphysical
12578829
RAB3C_MOUSERab3cphysical
12578829
RAB3D_MOUSERab3dphysical
12578829
RB27B_MOUSERab27bphysical
12578829
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RP3A_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-271, AND MASSSPECTROMETRY.

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