PAK3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PAK3_MOUSE
• UniProt AC: Q61036
• Protein Name: Serine/threonine-protein kinase PAK 3
• Gene Name: Pak3
• Organism: Mus musculus (Mouse).
• Sequence Length: 559
• Subcellular Localization: Cytoplasm.
• Protein Description: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. [PubMed: 25851601 Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.]
• Protein Sequence: MSDSLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHQSNTKTASEPPLAPPVSEEEDEEEEEEEDDNEPPPVIAPRPEHTKSIYTRSVVESIASPAAPNKEDIPPSAENANSTTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLIIAAKEAIKNSSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSDSLDNEE ------CCCCCCCCC	35.59	26824392
4	Phosphorylation	----MSDSLDNEEKP ----CCCCCCCCCCC	30.25	26643407
20	Phosphorylation	APPLRMNSNNRDSSA CCCCCCCCCCCCCCC	26.58	29514104
25	Phosphorylation	MNSNNRDSSALNHSS CCCCCCCCCCCCCCC	17.80	29550500
26	Phosphorylation	NSNNRDSSALNHSSK CCCCCCCCCCCCCCC	40.85	29550500
45	Acetylation	APEEKNKKARLRSIF CCHHHCHHHHHHHHC	48.40	7619027
50	Phosphorylation	NKKARLRSIFPGGGD CHHHHHHHHCCCCCC	32.92	29899451
120	Phosphorylation	WARLLQTSNITKLEQ HHHHHHHCCCHHHHH	17.18	29514104
124	Acetylation	LQTSNITKLEQKKNP HHHCCCHHHHHCCCH	46.35	22826441
139	Ubiquitination	QAVLDVLKFYDSKET HHHHHHHHHHCCCCC	41.55	-
143	Phosphorylation	DVLKFYDSKETVNNQ HHHHHHCCCCCCCCE	22.47	25338131
146	Phosphorylation	KFYDSKETVNNQKYM HHHCCCCCCCCEEEE	32.07	29899451
154	Phosphorylation	VNNQKYMSFTSGDKS CCCEEEEEEECCCCC	23.45	26824392
156	Phosphorylation	NQKYMSFTSGDKSAH CEEEEEEECCCCCCC	25.21	29550500
157	Phosphorylation	QKYMSFTSGDKSAHG EEEEEEECCCCCCCE	42.88	29899451
161	Phosphorylation	SFTSGDKSAHGYIAA EEECCCCCCCEEEEE	30.18	23684622
165	Phosphorylation	GDKSAHGYIAAHQSN CCCCCCEEEEEECCC	4.22	29514104
171	Phosphorylation	GYIAAHQSNTKTASE EEEEEECCCCCCCCC	36.28	23684622
175	Phosphorylation	AHQSNTKTASEPPLA EECCCCCCCCCCCCC	33.12	25619855
177	Phosphorylation	QSNTKTASEPPLAPP CCCCCCCCCCCCCCC	56.73	25619855
186	Phosphorylation	PPLAPPVSEEEDEEE CCCCCCCCHHHCHHH	45.09	25521595
213	Phosphorylation	IAPRPEHTKSIYTRS CCCCHHCCCCCHHHH	25.48	25619855
215	Phosphorylation	PRPEHTKSIYTRSVV CCHHCCCCCHHHHHH	23.22	29550500
217	Phosphorylation	PEHTKSIYTRSVVES HHCCCCCHHHHHHHH	11.82	29550500
218	Phosphorylation	EHTKSIYTRSVVESI HCCCCCHHHHHHHHH	18.13	29550500
220	Phosphorylation	TKSIYTRSVVESIAS CCCCHHHHHHHHHCC	23.79	27180971
224	Phosphorylation	YTRSVVESIASPAAP HHHHHHHHHCCCCCC	16.31	26643407
227	Phosphorylation	SVVESIASPAAPNKE HHHHHHCCCCCCCCC	17.25	26643407
239	Phosphorylation	NKEDIPPSAENANST CCCCCCCCCCCCCCC	42.75	25777480
245	Phosphorylation	PSAENANSTTLYRNT CCCCCCCCCCEECCC	21.99	25777480
246	Phosphorylation	SAENANSTTLYRNTD CCCCCCCCCEECCCH	22.19	25777480
247	Phosphorylation	AENANSTTLYRNTDR CCCCCCCCEECCCHH	22.93	25777480
249	Phosphorylation	NANSTTLYRNTDRQR CCCCCCEECCCHHHH	10.34	25777480
259	Phosphorylation	TDRQRKKSKMTDEEI CHHHHHHHCCCHHHH	30.60	29899451
272	Phosphorylation	EILEKLRSIVSVGDP HHHHHHHHHHCCCCC	37.47	25521595
275	Phosphorylation	EKLRSIVSVGDPKKK HHHHHHHCCCCCCCC	20.79	-
404	Ubiquitination	QVIHRDIKSDNILLG CCEECCCCCCCEEEC	56.92	-
435	Phosphorylation	TPEQSKRSTMVGTPY CHHHHCCCCCCCCCC	25.29	25266776
436	Phosphorylation	PEQSKRSTMVGTPYW HHHHCCCCCCCCCCC	21.65	25521595
440	Phosphorylation	KRSTMVGTPYWMAPE CCCCCCCCCCCCCCH	11.20	22322096
442	Phosphorylation	STMVGTPYWMAPEVV CCCCCCCCCCCCHHH	13.98	29550500
538	Succinylation	HPFLKLAKPLSSLTP CHHHHHHCCHHHCHH	57.85	23806337
538	Acetylation	HPFLKLAKPLSSLTP CHHHHHHCCHHHCHH	57.85	23806337

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PAK3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PAK3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PAK3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RHOQ_HUMAN	RHOQ	physical	10445846
ARHG7_MOUSE	Arhgef7	physical	9726964

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.