RHOQ_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RHOQ_HUMAN
• UniProt AC: P17081
• Protein Name: Rho-related GTP-binding protein RhoQ
• Gene Name: RHOQ
• Organism: Homo sapiens (Human).
• Sequence Length: 205
• Subcellular Localization: Cytoplasm . Cell membrane ; Lipid-anchor .
• Protein Description: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia..
• Protein Sequence: MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLGLYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELKEYAPNVPFLLIGTQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQKGLKTVFDEAIIAILTPKKHTVKKRIGSRCINCCLIT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	S-palmitoylation	PGALMLKCVVVGDGA CCEEEEEEEEECCCC	2.18	29575903
23	Phosphorylation	GDGAVGKTCLLMSYA CCCCCCHHHHHHHHC	11.49	21406692
28	Phosphorylation	GKTCLLMSYANDAFP CHHHHHHHHCCCCCC	22.51	21406692
29	Phosphorylation	KTCLLMSYANDAFPE HHHHHHHHCCCCCCH	8.75	21406692
38	Phosphorylation	NDAFPEEYVPTVFDH CCCCCHHHCCCCCCE	15.29	21406692
41	Phosphorylation	FPEEYVPTVFDHYAV CCHHHCCCCCCEEEE	24.62	21406692
46	Phosphorylation	VPTVFDHYAVSVTVG CCCCCCEEEEEEEEC	15.56	21406692
49	Phosphorylation	VFDHYAVSVTVGGKQ CCCEEEEEEEECCEE	12.14	21406692
51	Phosphorylation	DHYAVSVTVGGKQYL CEEEEEEEECCEEEE	13.11	21406692
70	Phosphorylation	DTAGQEDYDRLRPLS CCCCCCCHHHCCCCC	11.38	20736484
160	Phosphorylation	KEIGACCYVECSALT HHHCCCEEEECHHHC	10.12	29759185
163	S-palmitoylation	GACCYVECSALTQKG CCCEEEECHHHCHHC	1.74	29575903
164	Phosphorylation	ACCYVECSALTQKGL CCEEEECHHHCHHCH	16.89	29759185
169	Ubiquitination	ECSALTQKGLKTVFD ECHHHCHHCHHHHHC	62.06	2189047
169	Acetylation	ECSALTQKGLKTVFD ECHHHCHHCHHHHHC	62.06	25953088
172	Ubiquitination	ALTQKGLKTVFDEAI HHCHHCHHHHHCHHH	51.84	-
173	Phosphorylation	LTQKGLKTVFDEAII HCHHCHHHHHCHHHH	31.29	-
202	Methylation	GSRCINCCLIT---- CCCEEEEEEEC----	2.38	-
202	Farnesylation	GSRCINCCLIT---- CCCEEEEEEEC----	2.38	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RHOQ_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RHOQ_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RHOQ_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GOPC_HUMAN	GOPC	physical	11162552
EXOC7_HUMAN	EXOC7	physical	12687004
PAR6B_HUMAN	PARD6B	physical	11162552
CIP4_HUMAN	TRIP10	physical	12242347
GOPC_HUMAN	GOPC	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.