SHRM3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SHRM3_MOUSE
• UniProt AC: Q9QXN0
• Protein Name: Protein Shroom3
• Gene Name: Shroom3
• Organism: Mus musculus (Mouse).
• Sequence Length: 1986
• Subcellular Localization: Cell junction, adherens junction . Cytoplasm, cytoskeleton . Colocalizes with F-actin in stress fibers and adherens junctions.
• Protein Description: Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers. Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays..
• Protein Sequence: MKTPENLEEPSATPNPSRTPTERFVYLEALLEGGAPWGFTLKGGLERGEPLIISKIEEGGKADSVSSGLQAGDEVIHINEVALSSPRREAVSLVKGSYKTLRLVVRRDVCAAPGHADPGTSKSLSSELLTCSPQHRKATWSGGVKLRLKQRCSEPATRPHSWHTTKFGETQPDVSMMQISQGTMGPPWHQSYHSSSSTSDLSNYDHAYLRRSPDQCSSQGSMESLEPSGGYPPCHLLSPAKSTSSIDQLGHLHNKRDSAYSSFSTSSSIFEYPPPGGSARERSGSMDVISARGGLLEGMRQADIRYVKTVYDTRRGVSSEYEVNPSALLLQGRDAHASADSQGCAKWHSIPRGKGTPSPSWSQQCSGSLETATDNLPQKAGAPLPPTRSDSYAAFRHRERPSSWSSLDQKRFCRPQTNSSGSQKTPFAEDQLHTVPERSPENSPPVKSKHNYTQKAQPGQPLLPTGIYPVPSPEPHFAQVPQPSVSSNGTVYPALVKESGYTAAQGTCNKMATLDENGNQNEASRPGFAFCQPLEHNSVTPVEKRPEPTAKYIYKVHFSSVPENEDSSLKRHITPPHGHSPYPSERKNIHGGSRACSNHHSLSSPQAQALHVGDDRRPSRLSQPWEGDFQEDHNANLRQKVEREGQGQGLSGNSGRTRSAFSSLQNIPESLRRQSNVELGEAQEVHPGGRSKVEDPGRKAGASDIRGYLDRSVSYPRPEGKMNAVDSVHSADSRYEESPAPALPQTSGASQRRLSSSSSAAPQYRKPHCSVLEKVSRIEEREQGRHRPLSVGSSAYGPGYRPGRTGPTPSTSSSDLDDPKAGSVHFSESTEHLRNGEQNPPNGEAKQEEASRPQCSHLIRRAPADGRGPPARGGEPSRPEARLLRSQSTFQLYSEAEREASWSEDRPGTPESPLLDAPFSRAYRNSIKDAQSRVLGATSFRRRDLEPGTPATSRPWRPRPASAHVGMRSPEAAVPSSSPHTPRERHSVTPAAPQAARRGPRRRLTVEQKKRSYSEPEKMNEVGVSEEAEPTPCGPPRPAQPRFSESTVADRRRIFERDGKACSTLSLSGPELKQFQQSALADYIQRKTGKRPTGAACTPEAGLRERAQSAYLQAGPAAPDGPGLASACSLSSLREPEALPRKEHTHPSAADGPQAPRDRSSSFASGRLVGERRRWDPQVPRQLLSGANCEPRGVQRMDGAPGGPPSWGMVAGKAGKSKSAEDLLERSDTLAVPVHVRSRSSPTSDKKGQDVLLREGSNFGFVKDPCCLAGPGPRSLSCSDKGQNELALPLHHPTPCWNGSGCKATVASSAPPESSGAADHLKQRRAPGPRPLSAGMHGHFPDARAASLSSPLPSPVPSASPVPSSYRSQLAMDQQTGQQPPSSPASAVTQPTSPRSPELSSPAYGLGEGMWKRTSLPQRPPPPWVKWAHAVREDGLAEDTLAPEFANLKHYRNQPSRPSSCSTSDPDTPGRISLRISESALQPSPPPRGDYDDEVFMKDLHPKVTSSPTFEALPPPPPPSPPSEEPLVNGTDDFPPPPPPQALCEVLLDGEASTEAGSGPCRIPRVMVTREGHVPGAAHSEGSQIMTATPPQTSAKGSEAESNTPSSASAQPQLNGSPGKQLCPSQTRNLTYEPVERTQDLGKKTHAEPQKTSEDIRTEALAKEIVHQDKSLADILDPDSRMKTTMDLMEGLFPGDASVLMDSGAKRKALDITARRAGCEAKASDHKEAVSVLVNCPAYYSVSAAKAELLNKIKDMPEELQEEEGQEDVNEKKAELIGSLTHKLESLQEAKGSLLTDIKLNNALGEEVEALISELCKPNEFDKYKMFIGDLDKVVNLLLSLSGRLARVENVLRGLGEDASKEERSSLNEKRKVLAGQHEDARELKENLDRRERVVLDILANYLSAEQLQDYQHFVKMKSTLLIEQRKLDDKIKLGQEQVRCLLESLPSDFRPKAGAISLPPALTGHATPGGTSVFGGVFPTLTSPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Phosphorylation	TPTERFVYLEALLEG CCCHHHHHHHHHHHC	8.98	22871156
95	Ubiquitination	REAVSLVKGSYKTLR HHHHHHHCCCHHHHE	47.64	-
98	Phosphorylation	VSLVKGSYKTLRLVV HHHHCCCHHHHEEEE	19.36	28059163
100	Phosphorylation	LVKGSYKTLRLVVRR HHCCCHHHHEEEEEC	14.63	22942356
125	Phosphorylation	PGTSKSLSSELLTCS CCCCHHHHHHHHHCC	28.94	24899341
132	Phosphorylation	SSELLTCSPQHRKAT HHHHHHCCHHHCCCC	23.51	24899341
196	Phosphorylation	HQSYHSSSSTSDLSN HHHCCCCCCCHHHCC	40.42	-
199	Phosphorylation	YHSSSSTSDLSNYDH CCCCCCCHHHCCCCH	38.20	-
212	Phosphorylation	DHAYLRRSPDQCSSQ CHHHHCCCCCHHCCC	26.79	27742792
218	Phosphorylation	RSPDQCSSQGSMESL CCCCHHCCCCCHHHC	46.30	21183079
221	Phosphorylation	DQCSSQGSMESLEPS CHHCCCCCHHHCCCC	16.25	21082442
242	Phosphorylation	HLLSPAKSTSSIDQL CCCCCCCCCCCHHHH	35.31	28507225
243	Phosphorylation	LLSPAKSTSSIDQLG CCCCCCCCCCHHHHH	26.28	28507225
244	Phosphorylation	LSPAKSTSSIDQLGH CCCCCCCCCHHHHHC	32.18	29472430
245	Phosphorylation	SPAKSTSSIDQLGHL CCCCCCCCHHHHHCC	30.21	28973931
283	Phosphorylation	GGSARERSGSMDVIS CCCHHHCCCCCCEEE	30.39	24759943
285	Phosphorylation	SARERSGSMDVISAR CHHHCCCCCCEEECC	17.04	26239621
349	Phosphorylation	QGCAKWHSIPRGKGT CCCCCCCCCCCCCCC	32.92	21659605
391	Phosphorylation	LPPTRSDSYAAFRHR CCCCCCCCHHHHCCC	20.23	21183079
402	Phosphorylation	FRHRERPSSWSSLDQ HCCCCCCCCCCCCCC	51.14	21183079
403	Phosphorylation	RHRERPSSWSSLDQK CCCCCCCCCCCCCCC	33.39	25521595
405	Phosphorylation	RERPSSWSSLDQKRF CCCCCCCCCCCCCCC	23.99	-
425	Phosphorylation	NSSGSQKTPFAEDQL CCCCCCCCCCCCHHH	18.92	23984901
434	Phosphorylation	FAEDQLHTVPERSPE CCCHHHCCCCCCCCC	46.47	27087446
439	Phosphorylation	LHTVPERSPENSPPV HCCCCCCCCCCCCCC	34.60	27087446
443	Phosphorylation	PERSPENSPPVKSKH CCCCCCCCCCCCCCC	28.99	27087446
580	Phosphorylation	ITPPHGHSPYPSERK CCCCCCCCCCCCCCC	30.62	-
659	Phosphorylation	GNSGRTRSAFSSLQN CCCCCCHHHHHHHHC	32.81	19060867
662	Phosphorylation	GRTRSAFSSLQNIPE CCCHHHHHHHHCCCH	29.83	26239621
663	Phosphorylation	RTRSAFSSLQNIPES CCHHHHHHHHCCCHH	27.76	26824392
670	Phosphorylation	SLQNIPESLRRQSNV HHHCCCHHHHHHHCC	23.09	23984901
675	Phosphorylation	PESLRRQSNVELGEA CHHHHHHHCCCCCCC	40.82	25521595
712	Phosphorylation	IRGYLDRSVSYPRPE HHHHHHCCCCCCCCC	18.32	26643407
714	Phosphorylation	GYLDRSVSYPRPEGK HHHHCCCCCCCCCCC	30.57	26643407
715	Phosphorylation	YLDRSVSYPRPEGKM HHHCCCCCCCCCCCC	10.91	26643407
755	Phosphorylation	GASQRRLSSSSSAAP CCCCHHHCCCCCCCC	26.77	25521595
756	Phosphorylation	ASQRRLSSSSSAAPQ CCCHHHCCCCCCCCH	38.54	26239621
757	Phosphorylation	SQRRLSSSSSAAPQY CCHHHCCCCCCCCHH	25.57	26239621
758	Phosphorylation	QRRLSSSSSAAPQYR CHHHCCCCCCCCHHC	26.41	26239621
759	Phosphorylation	RRLSSSSSAAPQYRK HHHCCCCCCCCHHCC	30.33	26239621
764	Phosphorylation	SSSAAPQYRKPHCSV CCCCCCHHCCCCCHH	21.39	28576409
790	Phosphorylation	QGRHRPLSVGSSAYG CCCCCCCCCCCCCCC	27.41	26239621
811	Phosphorylation	RTGPTPSTSSSDLDD CCCCCCCCCHHHCCC	33.56	22817900
812	Phosphorylation	TGPTPSTSSSDLDDP CCCCCCCCHHHCCCC	31.98	19060867
829	Phosphorylation	GSVHFSESTEHLRNG CCEECCCCHHHHHCC	37.59	28973931
886	Phosphorylation	PEARLLRSQSTFQLY HHHHHHHCCCHHHHH	28.58	27087446
888	Phosphorylation	ARLLRSQSTFQLYSE HHHHHCCCHHHHHHH	32.22	25521595
889	Phosphorylation	RLLRSQSTFQLYSEA HHHHCCCHHHHHHHH	14.04	23737553
901	Phosphorylation	SEAEREASWSEDRPG HHHHHHHCCCCCCCC	26.78	26239621
903	Phosphorylation	AEREASWSEDRPGTP HHHHHCCCCCCCCCC	27.42	25293948
909	Phosphorylation	WSEDRPGTPESPLLD CCCCCCCCCCCCCCC	26.94	21082442
912	Phosphorylation	DRPGTPESPLLDAPF CCCCCCCCCCCCCCC	23.27	21082442
920	Phosphorylation	PLLDAPFSRAYRNSI CCCCCCCCHHHHHHH	18.23	22324799
926	Phosphorylation	FSRAYRNSIKDAQSR CCHHHHHHHHHHHHH	23.24	-
928	Acetylation	RAYRNSIKDAQSRVL HHHHHHHHHHHHHHH	47.00	7619387
939	Phosphorylation	SRVLGATSFRRRDLE HHHHCCCCCCCCCCC	19.07	26824392
949	Phosphorylation	RRDLEPGTPATSRPW CCCCCCCCCCCCCCC	22.07	-
969	Phosphorylation	SAHVGMRSPEAAVPS CCCCCCCCCCCCCCC	20.42	28507225
976	Phosphorylation	SPEAAVPSSSPHTPR CCCCCCCCCCCCCCC	36.53	29895711
977	Phosphorylation	PEAAVPSSSPHTPRE CCCCCCCCCCCCCCC	41.65	29472430
978	Phosphorylation	EAAVPSSSPHTPRER CCCCCCCCCCCCCCC	25.66	22817900
981	Phosphorylation	VPSSSPHTPRERHSV CCCCCCCCCCCCCCC	27.68	22817900
987	Phosphorylation	HTPRERHSVTPAAPQ CCCCCCCCCCCCCHH	33.63	28973931
1005	Phosphorylation	RGPRRRLTVEQKKRS HCCCCCCCHHHHHHC	21.86	-
1012	Phosphorylation	TVEQKKRSYSEPEKM CHHHHHHCCCCCHHH	41.72	26824392
1014	Phosphorylation	EQKKRSYSEPEKMNE HHHHHCCCCCHHHHC	48.17	27087446
1046	Phosphorylation	AQPRFSESTVADRRR CCCCCCCCHHHHHHH	27.30	-
1063	Phosphorylation	ERDGKACSTLSLSGP HCCCCCCCCCCCCCH	36.92	26239621
1064	Phosphorylation	RDGKACSTLSLSGPE CCCCCCCCCCCCCHH	21.91	26239621
1066	Phosphorylation	GKACSTLSLSGPELK CCCCCCCCCCCHHHH	22.15	22817900
1129	Phosphorylation	PGLASACSLSSLREP CCHHHHCCHHHCCCC	30.88	23737553
1131	Phosphorylation	LASACSLSSLREPEA HHHHCCHHHCCCCCC	15.84	25159016
1132	Phosphorylation	ASACSLSSLREPEAL HHHCCHHHCCCCCCC	36.42	23737553
1172 (in isoform 4)	Phosphorylation	-	27.77	26239621
1174 (in isoform 4)	Phosphorylation	-	48.66	26239621
1175 (in isoform 4)	Phosphorylation	-	21.59	26239621
1179 (in isoform 4)	Phosphorylation	-	5.26	22817900
1183 (in isoform 4)	Phosphorylation	-	4.31	25293948
1184 (in isoform 4)	Phosphorylation	-	3.16	25293948
1185 (in isoform 4)	Phosphorylation	-	44.44	25293948
1217	Phosphorylation	VAGKAGKSKSAEDLL HCCCCCCCCCHHHHH	30.81	23984901
1219	Phosphorylation	GKAGKSKSAEDLLER CCCCCCCCHHHHHHC	43.94	25521595
1227	Phosphorylation	AEDLLERSDTLAVPV HHHHHHCCCEEEEEE	26.10	26239621
1229	Phosphorylation	DLLERSDTLAVPVHV HHHHCCCEEEEEEEE	20.19	26239621
1238	Phosphorylation	AVPVHVRSRSSPTSD EEEEEEECCCCCCCC	35.11	27087446
1240	Phosphorylation	PVHVRSRSSPTSDKK EEEEECCCCCCCCCC	41.75	27087446
1241	Phosphorylation	VHVRSRSSPTSDKKG EEEECCCCCCCCCCC	30.96	27087446
1247	Ubiquitination	SSPTSDKKGQDVLLR CCCCCCCCCCEEEEC	67.79	22790023
1347 (in isoform 3)	Phosphorylation	-	28.00	26239621
1349 (in isoform 3)	Phosphorylation	-	27.67	26239621
1350	Phosphorylation	ARAASLSSPLPSPVP CHHHHCCCCCCCCCC	35.43	22817900
1350 (in isoform 3)	Phosphorylation	-	35.43	26239621
1354	Phosphorylation	SLSSPLPSPVPSASP HCCCCCCCCCCCCCC	46.33	-
1354 (in isoform 3)	Phosphorylation	-	46.33	22817900
1358 (in isoform 3)	Phosphorylation	-	41.43	25293948
1359 (in isoform 3)	Phosphorylation	-	16.28	25293948
1360 (in isoform 3)	Phosphorylation	-	30.67	25293948
1376	Phosphorylation	QLAMDQQTGQQPPSS HHCHHCCCCCCCCCC	31.18	25293948
1382	Phosphorylation	QTGQQPPSSPASAVT CCCCCCCCCCCCCCC	56.49	25293948
1383	Phosphorylation	TGQQPPSSPASAVTQ CCCCCCCCCCCCCCC	30.20	25293948
1386	Phosphorylation	QPPSSPASAVTQPTS CCCCCCCCCCCCCCC	27.02	25293948
1389	Phosphorylation	SSPASAVTQPTSPRS CCCCCCCCCCCCCCC	28.66	25293948
1392	Phosphorylation	ASAVTQPTSPRSPEL CCCCCCCCCCCCCCC	41.36	25293948
1393	Phosphorylation	SAVTQPTSPRSPELS CCCCCCCCCCCCCCC	25.62	25293948
1396	Phosphorylation	TQPTSPRSPELSSPA CCCCCCCCCCCCCCC	26.55	25293948
1400	Phosphorylation	SPRSPELSSPAYGLG CCCCCCCCCCCCCCC	32.39	25293948
1401	Phosphorylation	PRSPELSSPAYGLGE CCCCCCCCCCCCCCC	26.61	25293948
1404	Phosphorylation	PELSSPAYGLGEGMW CCCCCCCCCCCCCCC	19.10	25293948
1473	Phosphorylation	PDTPGRISLRISESA CCCCCCEEEEEECCC	15.38	23140645
1479	Phosphorylation	ISLRISESALQPSPP EEEEEECCCCCCCCC	27.73	29472430
1484	Phosphorylation	SESALQPSPPPRGDY ECCCCCCCCCCCCCC	36.76	26239621
1491	Phosphorylation	SPPPRGDYDDEVFMK CCCCCCCCCCCCCHH	28.28	25293948
1617	Phosphorylation	AQPQLNGSPGKQLCP CCCCCCCCCCCCCCC	29.43	25293948
1645	Phosphorylation	TQDLGKKTHAEPQKT HHHHCHHCCCCCCCC	29.79	20139300
1653	Phosphorylation	HAEPQKTSEDIRTEA CCCCCCCCHHHHHHH	40.06	20139300
1680	Phosphorylation	ADILDPDSRMKTTMD HHHCCCCCCCHHHHH	39.40	23140645
1870	Acetylation	ERSSLNEKRKVLAGQ HHHHHHHHHHHHHCC	57.35	19843515
1872	Acetylation	SSLNEKRKVLAGQHE HHHHHHHHHHHCCCH	53.31	19843525
1931	Acetylation	EQRKLDDKIKLGQEQ EECCCCHHHCCCHHH	41.21	15621191
1984	Phosphorylation	GVFPTLTSPL----- CCCCCCCCCC-----	100.00	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SHRM3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SHRM3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SHRM3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SH3R1_MOUSE	Sh3rf1	physical	18829867
ROCK1_MOUSE	Rock1	physical	18829867

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439; SER-443; SER-888AND THR-909, AND MASS SPECTROMETRY.
PubMed: 17242355