DSCAM_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DSCAM_MOUSE
• UniProt AC: Q9ERC8
• Protein Name: Down syndrome cell adhesion molecule homolog
• Gene Name: Dscam
• Organism: Mus musculus (Mouse).
• Sequence Length: 2013
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Cell projection, axon . Cell junction, synapse . Localized in the soma, cell membrane, axon and growth cone of dissociated commissural axons.
• Protein Description: Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. [PubMed: 18216855]
• Protein Sequence: MWILALSLFQSFANVFSEEPHSSLYFVNASLQEVVFASTSGTLVPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYVTVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLLIENSRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGNEDQELSWYRNGEILNPGKNVRITGLNHANLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLVCNVKGTPLPTVTWTLDDDPILKGSGHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNANLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPASLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQRKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNEITITADEAAPDGPPQEVHLEPTSSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISIDTTGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLIDGELGEIKNVTTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCVANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDGSTIPPLIKSVVQSEEGLTTNEGLKILVTISCILVGVLLLFVLLLVVRRRRREQRLKRLRDAKSLAEMLMSKNTRTSDTLSKQQQTLRMHIDIPRAQLLIEERDTMETIDDRSTVLLTDADFGEAAKQKSLTVTHTVHYQSVSQATGPLVDVSDARPGTNPTTRRNAKAGPTARNRYASQWTLNRPHPTISAHTLTTDWRLPTPRATGSVDKESDSYSVSPSQDTDRARSSMVSTESASSTYEELARAYEHAKMEEQLRHAKFTITECFISDTSSEQLTAGTNEYTDSLTSSTPSESGICRFTASPPKPQDGGRVVNMAVPKAHRPGDLIHLPPYLRMDFLLNRGAPGTSRDLSLGQACLEPQKSRTLKRPTVLEPTPMEASSSTSSTREGQQSWQQGAVATLPQREGAELGQAAKMSSSQESLLDSRGHLKGNNPYAKSYTLV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
78	N-linked_Glycosylation	GIRHVHPNGTLQIFP CCCEECCCCCEEEEE	41.00	-
299	Phosphorylation	VCEVSNRYGTAKVIG EEEEECCCCCEEEEE	24.07	22807455
301	Phosphorylation	EVSNRYGTAKVIGRL EEECCCCCEEEEEEE	17.86	22807455
470	N-linked_Glycosylation	GNVVSYLNISSSQVR CCEEEEEEECCCCEE	24.70	-
521	Phosphorylation	TAIAGRDTYIHCRVI EEEECCCCEEEEEEC	24.02	25777480
522	Phosphorylation	AIAGRDTYIHCRVIG EEECCCCEEEEEECC	7.92	25777480
530	Phosphorylation	IHCRVIGYPYYSIKW EEEEECCCCCCEEEE	4.12	25777480
532	Phosphorylation	CRVIGYPYYSIKWYK EEECCCCCCEEEEEE	11.02	25777480
533	Phosphorylation	RVIGYPYYSIKWYKN EECCCCCCEEEEEEC	10.22	25777480
534	Phosphorylation	VIGYPYYSIKWYKNA ECCCCCCEEEEEECC	16.32	25777480
666	N-linked_Glycosylation	LSLMHNGNYTCIARN EEEEECCCEEEEEEC	33.97	-
779	Phosphorylation	VGADVSKSMYLTVKI CCCCCCHHCEEEEEE	12.73	-
939	Phosphorylation	AQRTKDVSPQLNSAT HHHHCCCCCCCCCEE	19.64	28285833
961	Phosphorylation	STYSIRMYAKNRIGK CCCEEEEEEECCCCC	12.46	28285833
1160	N-linked_Glycosylation	DGLEKYTNYSIQVLA CCHHHCCCCEEEEEE	26.01	-
1250	N-linked_Glycosylation	SFSYRIPNLSRNRQY CCEEECCCCCCCCCE	48.56	-
1337	Phosphorylation	VTIDGRRSIFSNGSF EEECCCEEECCCCCE	26.99	25619855
1340	Phosphorylation	DGRRSIFSNGSFIIR CCCEEECCCCCEEEE	38.31	25619855
1343	Phosphorylation	RSIFSNGSFIIRTVK EEECCCCCEEEEEEE	19.95	25619855
1490	Phosphorylation	LFASINTTRVRLNLI HHHHCCCCEEEEEEE	23.76	28059163
1772	Phosphorylation	TTDWRLPTPRATGSV ECCCCCCCCCCCCCC	29.96	24719451
1776	Phosphorylation	RLPTPRATGSVDKES CCCCCCCCCCCCCCC	31.13	29899451
1791	Phosphorylation	DSYSVSPSQDTDRAR CCCCCCCCCCCHHHH	32.93	29899451
1809	Phosphorylation	VSTESASSTYEELAR CCCHHHHHHHHHHHH	34.42	20139300
1811	Phosphorylation	TESASSTYEELARAY CHHHHHHHHHHHHHH	14.89	20139300
1992	Phosphorylation	KMSSSQESLLDSRGH HCCCCHHHHHHCCCC	26.96	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DSCAM_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DSCAM_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DSCAM_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DSCAM_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.