MPDZ_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MPDZ_MOUSE
• UniProt AC: Q8VBX6
• Protein Name: Multiple PDZ domain protein
• Gene Name: Mpdz
• Organism: Mus musculus (Mouse).
• Sequence Length: 2055
• Subcellular Localization: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Cell junction, tight ju
• Protein Description: Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (By similarity)..
• Protein Sequence: MLETIDKNRALQAAERLQSKLKERGDVANEDKLSLLKSVLQSPLFSQILNLQTSLQQLKDQVNIATLATAAADHAHTPQFSSAVISNLQSESLLLSPNHGNLEALPGPGAPAVMDGKPTCDELDQLIKNMAQGRHVEIFELLKPPCGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQVLDQTITHQQAISILQKAKDTVQLVIARGSLPPVSSPRISRSPSAASTISAHSNPMHWQHVETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAVEETPASSSLGITLSSSTSSTSEMRVDASTQKNDESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVRLTLMRKGASQEAELTSRGDTAKDVDLPAENCEKDEESLSLKRNTSILPIEEEGFPLLSAELEEAEDVQQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGINLLGENHQDVVNILKELPIDVTMVCCRRTVPPIALSEMDSLDINDLELTEKPHIDLGEFIGSSETEDPMLAMSDVDQNAEEIQTPLAMWEAGGQSIELEKGSRGLGFSILDYQDPIDPANTVIVIRSLVPGGIAEKDGRLFPGDRLMFVNDINLENSTLEEAVEALKGAPSGMVRIGVAKPLPLSPEEGYVSAKEDAFLCSPHACKESGLSDKALFRADLALIDTPDAESIAESRFESQFSPDNDSVYSTQASIFSLHDGTCSDGMNYGPSLPSSPPKDVTSSSEVVLGLHLSLEELYTQNLLQRQHAGSPPTDMRPAPTSGFPISDYTTTNAVEQKYECANPVAWPHSQLPSSLSTSELAPALPAVAQKYLTDQSSLASDAESVNLQSMSQEAFERTVTIAKGSSSLGMTVSANKDGLGVIVRSIIHGGAISRDGRIAVGDCILSINEESTISLTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFRVSFGQQAGGIMALDIFSSYTGRDIPELPEREEGEGEESELQNAAYSSWSQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIIEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLPHSLYPKYSFSSTNPFADSLQLTTDQAPSQSESETEKPALCNVPPSSPSVFSEMGSDCAQPSATAVSEDEDKEDEFGYSWKNIQERYGSLTGQLHVIELEKGQSGLGLSLAGNKDRTRMSVFIVGIDPTGAAGRDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNADAVNQMAVCPGIAADSPSSTSDSPQNKEVEPCSTTSASAADLSSLTDVYQLELPKDQGGLGIAICEEDTINGVMIESLTEHGGAAKDGRLKPGDHILAVDDEVVAGCPVEKFISLLKTAKATVKLTVRAENPACPAVPSSAVTVSGERKDNSQTPAVPAPDLEPIPSTSRSSTPAVFASDPATCPIIPGCETTIEISKGQTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEDVCDTFTIELQKRPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRHATQEAVAALLKCSLGAVTLEVGRVKAAPFHSERRPSQSSQVSESSLSSFTPPLSGINTSESLESNSKKNALASEIQGLRTVEIKKGPADSLGLSIAGGVGSPLGDVPIFIAMMHPNGVAAQTQKLRVGDRIVTICGTSTDGMTHTQAVNLMKNASGSIEVQVVAGGDVSVVTGHQQELANPCLAFTGLTSSSIFPDDLGPPQSKTITLDRGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAAAEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Phosphorylation	DKLSLLKSVLQSPLF HHHHHHHHHHHCHHH	28.20	26643407
42	Phosphorylation	LLKSVLQSPLFSQIL HHHHHHHCHHHHHHH	21.29	26643407
46	Phosphorylation	VLQSPLFSQILNLQT HHHCHHHHHHHCHHH	24.80	26643407
186	Phosphorylation	RDGRLKETDQILAIN CCCCCCCHHEEEEEC	31.45	-
225	Phosphorylation	QLVIARGSLPPVSSP EEEEECCCCCCCCCC	31.95	28066266
230	Phosphorylation	RGSLPPVSSPRISRS CCCCCCCCCCCCCCC	40.16	29899451
231	Phosphorylation	GSLPPVSSPRISRSP CCCCCCCCCCCCCCC	20.59	26824392
235	Phosphorylation	PVSSPRISRSPSAAS CCCCCCCCCCCCCCH	28.16	21659605
466	Phosphorylation	TLMRKGASQEAELTS EEEECCCCCEEEECC	36.90	24719451
494	Phosphorylation	NCEKDEESLSLKRNT HCCCCHHHHCCCCCC	22.62	22324799
496	Phosphorylation	EKDEESLSLKRNTSI CCCHHHHCCCCCCCC	40.92	22324799
501	Phosphorylation	SLSLKRNTSILPIEE HHCCCCCCCCCCCCC	22.60	26643407
502	Phosphorylation	LSLKRNTSILPIEEE HCCCCCCCCCCCCCC	26.19	27180971
783	Phosphorylation	VAKPLPLSPEEGYVS ECCCCCCCCCCCCCC	28.46	26643407
788	Phosphorylation	PLSPEEGYVSAKEDA CCCCCCCCCCCCCCC	8.43	26643407
799	Phosphorylation	KEDAFLCSPHACKES CCCCEEECHHHHHHC	23.13	25521595
823	Phosphorylation	ADLALIDTPDAESIA CCEEEECCCCHHHHH	18.97	26824392
828	Phosphorylation	IDTPDAESIAESRFE ECCCCHHHHHHHHHH	28.90	28066266
832	Phosphorylation	DAESIAESRFESQFS CHHHHHHHHHHCCCC	32.99	28066266
908	Phosphorylation	LQRQHAGSPPTDMRP HHHCCCCCCCCCCCC	28.61	26824392
911	Phosphorylation	QHAGSPPTDMRPAPT CCCCCCCCCCCCCCC	45.90	25521595
918	Phosphorylation	TDMRPAPTSGFPISD CCCCCCCCCCCCCCC	43.52	26643407
919	Phosphorylation	DMRPAPTSGFPISDY CCCCCCCCCCCCCCC	37.06	26643407
924	Phosphorylation	PTSGFPISDYTTTNA CCCCCCCCCCCCCCH	25.46	25777480
926	Phosphorylation	SGFPISDYTTTNAVE CCCCCCCCCCCCHHH	10.13	25777480
927	Phosphorylation	GFPISDYTTTNAVEQ CCCCCCCCCCCHHHH	31.94	25777480
928	Phosphorylation	FPISDYTTTNAVEQK CCCCCCCCCCHHHHH	16.30	26643407
929	Phosphorylation	PISDYTTTNAVEQKY CCCCCCCCCHHHHHE	17.24	25777480
969	Phosphorylation	LPAVAQKYLTDQSSL HHHHHHHHHCCHHHH	11.62	29899451
971	Phosphorylation	AVAQKYLTDQSSLAS HHHHHHHCCHHHHCC	28.98	29899451
1009	Phosphorylation	GSSSLGMTVSANKDG CCCCCCCEEEECCCC	14.98	19655815
1066	Phosphorylation	RAMLRRHSLIGPDIK HHHHHHHCCCCCCCE	21.63	25521595
1158	Methylation	GISIVGGRGMGSRLS CEEEECCCCCCCCCC	26.46	24129315
1182	Phosphorylation	IKHVLEDSPAGKNGT EEEECCCCCCCCCCC	13.79	28066266
1237	Phosphorylation	IINRPRKSPLPSLPH HHCCCCCCCCCCCCC	32.71	27841257
1238 (in isoform 2)	Phosphorylation	-	51.86	27818261
1240 (in isoform 2)	Phosphorylation	-	36.88	26643407
1242 (in isoform 2)	Phosphorylation	-	4.12	26643407
1244 (in isoform 2)	Phosphorylation	-	35.41	26643407
1271	Phosphorylation	LTTDQAPSQSESETE EECCCCCCCCCCCCC	49.72	29550500
1346	Phosphorylation	IELEKGQSGLGLSLA EEEECCCCCCCEEEC	44.66	30352176
1351	Phosphorylation	GQSGLGLSLAGNKDR CCCCCCEEECCCCCC	17.86	30352176
1437	Phosphorylation	CPGIAADSPSSTSDS CCCCCCCCCCCCCCC	23.19	26643407
1439	Phosphorylation	GIAADSPSSTSDSPQ CCCCCCCCCCCCCCC	50.64	26643407
1440	Phosphorylation	IAADSPSSTSDSPQN CCCCCCCCCCCCCCC	35.00	26643407
1441	Phosphorylation	AADSPSSTSDSPQNK CCCCCCCCCCCCCCC	40.67	26643407
1442	Phosphorylation	ADSPSSTSDSPQNKE CCCCCCCCCCCCCCC	37.73	26643407
1444	Phosphorylation	SPSSTSDSPQNKEVE CCCCCCCCCCCCCCC	28.31	26643407
1454	Phosphorylation	NKEVEPCSTTSASAA CCCCCCCCCCCCCHH	45.49	23984901
1455	Phosphorylation	KEVEPCSTTSASAAD CCCCCCCCCCCCHHH	31.33	23984901
1456	Phosphorylation	EVEPCSTTSASAADL CCCCCCCCCCCHHHH	13.15	23984901
1457	Phosphorylation	VEPCSTTSASAADLS CCCCCCCCCCHHHHH	21.95	23984901
1459	Phosphorylation	PCSTTSASAADLSSL CCCCCCCCHHHHHHC	24.61	23984901
1464	Phosphorylation	SASAADLSSLTDVYQ CCCHHHHHHCCCEEE	24.69	23984901
1465	Phosphorylation	ASAADLSSLTDVYQL CCHHHHHHCCCEEEE	42.45	23984901
1588	Phosphorylation	PDLEPIPSTSRSSTP CCCCCCCCCCCCCCC	39.47	25619855
1589	Phosphorylation	DLEPIPSTSRSSTPA CCCCCCCCCCCCCCC	23.86	25619855
1590	Phosphorylation	LEPIPSTSRSSTPAV CCCCCCCCCCCCCCE	34.21	25619855
1592	Phosphorylation	PIPSTSRSSTPAVFA CCCCCCCCCCCCEEC	38.03	26643407
1593	Phosphorylation	IPSTSRSSTPAVFAS CCCCCCCCCCCEECC	36.98	26643407
1594	Phosphorylation	PSTSRSSTPAVFASD CCCCCCCCCCEECCC	19.26	26643407
1600	Phosphorylation	STPAVFASDPATCPI CCCCEECCCCCCCCC	32.44	26643407
1672	Ubiquitination	VNGIDLRKATHDEAI ECCEECCCCCHHHHH	66.00	-
1803	Phosphorylation	FHSERRPSQSSQVSE CCCCCCCCCCCCCCH	40.66	27180971
1805	Phosphorylation	SERRPSQSSQVSESS CCCCCCCCCCCCHHH	27.37	25521595
1806	Phosphorylation	ERRPSQSSQVSESSL CCCCCCCCCCCHHHH	27.28	25521595
1809	Phosphorylation	PSQSSQVSESSLSSF CCCCCCCCHHHHHCC	24.91	26643407
1811	Phosphorylation	QSSQVSESSLSSFTP CCCCCCHHHHHCCCC	29.13	26643407
1812	Phosphorylation	SSQVSESSLSSFTPP CCCCCHHHHHCCCCC	28.37	26643407
1814	Phosphorylation	QVSESSLSSFTPPLS CCCHHHHHCCCCCCC	25.92	25293948
1815	Phosphorylation	VSESSLSSFTPPLSG CCHHHHHCCCCCCCC	38.13	26643407
1817	Phosphorylation	ESSLSSFTPPLSGIN HHHHHCCCCCCCCCC	26.41	29472430
1821	Phosphorylation	SSFTPPLSGINTSES HCCCCCCCCCCCHHH	43.32	29472430
1825	Phosphorylation	PPLSGINTSESLESN CCCCCCCCHHHHHHH	31.76	25293948
1826	Phosphorylation	PLSGINTSESLESNS CCCCCCCHHHHHHHH	22.24	25293948
1828	Phosphorylation	SGINTSESLESNSKK CCCCCHHHHHHHHHH	36.89	25293948
1831	Phosphorylation	NTSESLESNSKKNAL CCHHHHHHHHHHHHH	52.26	25293948
1833	Phosphorylation	SESLESNSKKNALAS HHHHHHHHHHHHHHH	55.04	25293948
1889	Phosphorylation	PNGVAAQTQKLRVGD CCCHHHHCCCCCCCC	23.97	29899451
2007	Acetylation	YVKTVFAKGAAAEDG EEEEEEECCCCCCCC	37.30	6568507

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MPDZ_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MPDZ_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MPDZ_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
JAM1_MOUSE	F11r	physical	11689568

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.