UniProt ID | JAM1_MOUSE | |
---|---|---|
UniProt AC | O88792 | |
Protein Name | Junctional adhesion molecule A | |
Gene Name | F11r | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 300 | |
Subcellular Localization |
Cell junction, tight junction . Cell membrane Single-pass type I membrane protein . Localized at tight junctions of both epithelial and endothelial cells. |
|
Protein Description | Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. [PubMed: 11447115 The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly] | |
Protein Sequence | MGTEGKAGRKLLFLFTSMILGSLVQGKGSVYTAQSDVQVPENESIKLTCTYSGFSSPRVEWKFVQGSTTALVCYNSQITAPYADRVTFSSSGITFSSVTRKDNGEYTCMVSEEGGQNYGEVSIHLTVLVPPSKPTISVPSSVTIGNRAVLTCSEHDGSPPSEYSWFKDGISMLTADAKKTRAFMNSSFTIDPKSGDLIFDPVTAFDSGEYYCQAQNGYGTAMRSEAAHMDAVELNVGGIVAAVLVTLILLGLLIFGVWFAYSRGYFERTKKGTAPGKKVIYSQPSTRSEGEFKQTSSFLV | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
42 | N-linked_Glycosylation | SDVQVPENESIKLTC CCCCCCCCCCEEEEE | 42.09 | 19349973 | |
49 | Glutathionylation | NESIKLTCTYSGFSS CCCEEEEEEECCCCC | 4.95 | 24333276 | |
90 | Phosphorylation | ADRVTFSSSGITFSS CCEEEEECCCEEEEE | 28.52 | 28285833 | |
96 | Phosphorylation | SSSGITFSSVTRKDN ECCCEEEEEEEECCC | 18.43 | 28285833 | |
97 | Phosphorylation | SSGITFSSVTRKDNG CCCEEEEEEEECCCC | 24.26 | 28285833 | |
152 | Glutathionylation | GNRAVLTCSEHDGSP CCEEEEEEECCCCCC | 3.82 | 24333276 | |
171 | Phosphorylation | SWFKDGISMLTADAK CHHHCCEEEEECCHH | 17.17 | - | |
174 | Phosphorylation | KDGISMLTADAKKTR HCCEEEEECCHHHHH | 17.53 | - | |
185 | N-linked_Glycosylation | KKTRAFMNSSFTIDP HHHHHHHHCCEEECC | 28.22 | 19656770 | |
277 | Ubiquitination | KKGTAPGKKVIYSQP CCCCCCCCEEEEECC | 42.69 | 27667366 | |
278 | Ubiquitination | KGTAPGKKVIYSQPS CCCCCCCEEEEECCC | 39.52 | 22790023 | |
281 | Phosphorylation | APGKKVIYSQPSTRS CCCCEEEEECCCCCC | 12.30 | 25177544 | |
282 | Phosphorylation | PGKKVIYSQPSTRSE CCCEEEEECCCCCCC | 25.21 | 25521595 | |
285 | Phosphorylation | KVIYSQPSTRSEGEF EEEEECCCCCCCCCC | 28.90 | 25521595 | |
286 | Phosphorylation | VIYSQPSTRSEGEFK EEEECCCCCCCCCCC | 44.92 | 25521595 | |
288 | Phosphorylation | YSQPSTRSEGEFKQT EECCCCCCCCCCCCC | 50.47 | 25521595 | |
293 | Ubiquitination | TRSEGEFKQTSSFLV CCCCCCCCCCCCCCC | 48.65 | - | |
295 | Phosphorylation | SEGEFKQTSSFLV-- CCCCCCCCCCCCC-- | 27.25 | 25293948 | |
296 | Phosphorylation | EGEFKQTSSFLV--- CCCCCCCCCCCC--- | 19.32 | 17242355 | |
297 | Phosphorylation | GEFKQTSSFLV---- CCCCCCCCCCC---- | 26.45 | 26239621 |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of JAM1_MOUSE !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of JAM1_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
CSKP_HUMAN | CASK | physical | 11120739 |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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N-linked Glycosylation | |
Reference | PubMed |
"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."; Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.; Nat. Biotechnol. 27:378-386(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-42 AND ASN-185, AND MASSSPECTROMETRY. | |
"The mouse C2C12 myoblast cell surface N-linked glycoproteome:identification, glycosite occupancy, and membrane orientation."; Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I.,Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E.,Wollscheid B.; Mol. Cell. Proteomics 8:2555-2569(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-185, AND MASSSPECTROMETRY. | |
Phosphorylation | |
Reference | PubMed |
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-285 AND SER-288, ANDMASS SPECTROMETRY. |