ASIC1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ASIC1_MOUSE
• UniProt AC: Q6NXK8
• Protein Name: Acid-sensing ion channel 1
• Gene Name: Asic1
• Organism: Mus musculus (Mouse).
• Sequence Length: 526
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Localizes in synaptosomes at dendritic synapses of neurons. Colocalizes with DLG4.
• Protein Description: Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear..
• Protein Sequence: MELKTEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFCYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEACSAEDFKVVFTRYGKCYTFNSGQDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQEQRLIYLPSPWGTCNAVTMDSDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHRLCRRGKCQKEAKRNSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
196	Ubiquitination	TRYGKCYTFNSGQDG EECCEEEEECCCCCC	26.30	27667366
366	N-linked_Glycosylation	CVCEMPCNLTRYGKE EEEECCCCCCCCCCC	38.28	-
382	Acetylation	SMVKIPSKASAKYLA EEEECCCHHHHHHHH	40.79	15616749
386	Acetylation	IPSKASAKYLAKKFN CCCHHHHHHHHHHCC	38.00	15616761
393	N-linked_Glycosylation	KYLAKKFNKSEQYIG HHHHHHCCCCHHHHC	56.68	-
454	Phosphorylation	TVLELFDYAYEVIKH HHHHHHHHHHHHHHH	12.07	-
456	Phosphorylation	LELFDYAYEVIKHRL HHHHHHHHHHHHHHH	12.42	-
477	Phosphorylation	QKEAKRNSADKGVAL HHHHHHCCCCCCCEE	41.71	19060867
485	Phosphorylation	ADKGVALSLDDVKRH CCCCCEECHHHHHHH	21.73	22324799
490	Ubiquitination	ALSLDDVKRHNPCES EECHHHHHHHCCCHH	55.74	27667366
491	Ubiquitination	LSLDDVKRHNPCESL ECHHHHHHHCCCHHH	34.36	27667366
497	Phosphorylation	KRHNPCESLRGHPAG HHHCCCHHHCCCCCC	30.04	21183079
506	Phosphorylation	RGHPAGMTYAANILP CCCCCCCCHHHHCCC	14.75	-
507	Phosphorylation	GHPAGMTYAANILPH CCCCCCCHHHHCCCC	8.53	-
523	Ubiquitination	PARGTFEDFTC---- CCCCCCCCCCC----	39.71	27667366
524	Ubiquitination	ARGTFEDFTC----- CCCCCCCCCC-----	6.22	27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
477	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ASIC1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ASIC1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ASIC2_MOUSE	Asic2	physical	19571134

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.