ASIC2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ASIC2_MOUSE
• UniProt AC: Q925H0
• Protein Name: Acid-sensing ion channel 2
• Gene Name: Asic2
• Organism: Mus musculus (Mouse).
• Sequence Length: 512
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Localized at the plasma membrane, in the soma and punctated peripheral processes of neurons.
• Protein Description: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate..
• Protein Sequence: MDLKESPSEGSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDPHLADPTVLEALRQKANFKHYKPKQFSMLEFLHRVGHDLKDMMLYCKFKGQECGHQDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEEEEGSHDENMSTCDTMPNHSETISHTVNVPLQTALGTLEEIAC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MDLKESPSEGSLQ --CCCCCCCCCCCCC	31.94	29899451
8	Phosphorylation	MDLKESPSEGSLQPS CCCCCCCCCCCCCCC	64.96	29899451
11	Phosphorylation	KESPSEGSLQPSSIQ CCCCCCCCCCCCEEE	21.56	20415495
15	Phosphorylation	SEGSLQPSSIQIFAN CCCCCCCCEEEEEEE	27.41	20415495
16	Phosphorylation	EGSLQPSSIQIFANT CCCCCCCEEEEEEEC	25.79	20415495
23	Phosphorylation	SIQIFANTSTLHGIR EEEEEEECCCCCCCC	21.47	20415495
24	Phosphorylation	IQIFANTSTLHGIRH EEEEEECCCCCCCCE	28.87	20415495
25	Phosphorylation	QIFANTSTLHGIRHI EEEEECCCCCCCCEE	22.27	20415495
77 (in isoform 2)	Phosphorylation	-	44.52	25159016
82 (in isoform 2)	Phosphorylation	-	26.20	25159016
365	N-linked_Glycosylation	CLCRTPCNLTRYNKE EEECCCCCCCCCCCC	45.72	-
392	N-linked_Glycosylation	KYLEKKFNKSEKYIS HHHHHHCCCCHHCCC	56.68	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ASIC2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ASIC2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ASIC2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ASIC1_MOUSE	Asic1	physical	19571134

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.