GABR2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GABR2_MOUSE
• UniProt AC: Q80T41
• Protein Name: Gamma-aminobutyric acid type B receptor subunit 2
• Gene Name: Gabbr2
• Organism: Mus musculus (Mouse).
• Sequence Length: 940
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane. In contrast, GABBR2
• Protein Description: Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. [PubMed: 10075644 Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (By similarity Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase]
• Protein Sequence: MASPPSSGQPRPPPPPPPPARLLLPLLLSLLLSLAPGAWGWARGAPRPPPSSPPLSIMGLMPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHFRWRRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAFEESMFGSKYQWIIPGWYEPAWWEQVHVEANSSRCLRRSLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQYEREYNSKRSGVGPSKFHGYAYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTGQVVFRNGERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVERYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILSLGNFTESTDGGKAILKNHLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPILHHAYLPSIGGVDASCVSPCVSPTASPRHRHVPPSFRVMVSGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
89	N-linked_Glycosylation	LAIEQIRNESLLRPY HHHHHHHCCCCCCCC	44.85	-
297	N-linked_Glycosylation	EQVHVEANSSRCLRR EEEEHHHHCHHHHHH	27.32	-
388	N-linked_Glycosylation	HQRIQDFNYTDHTLG HHHHHHCCCCHHHHH	47.27	-
403	N-linked_Glycosylation	RIILNAMNETNFFGV HHHHHHHCCCCCCCC	51.00	-
452	N-linked_Glycosylation	ADTLEIINDTIRFQG HHHHHHHHHCHHCCC	46.14	-
460	Phosphorylation	DTIRFQGSEPPKDKT HCHHCCCCCCCCCCC	35.83	22871156
628	Phosphorylation	RRTVERYSMEPDPAG HHHHHHHCCCCCCCC	23.92	25266776
762	Phosphorylation	QNRRFQFTQNQKKED CCHHEEECCCCCCCC	18.81	22324799
766	Ubiquitination	FQFTQNQKKEDSKTS EEECCCCCCCCCCCC	66.72	22790023
770	Phosphorylation	QNQKKEDSKTSTSVT CCCCCCCCCCCCCCE	38.64	22817900
772	Phosphorylation	QKKEDSKTSTSVTSV CCCCCCCCCCCCEEC	40.98	25521595
773	Phosphorylation	KKEDSKTSTSVTSVN CCCCCCCCCCCEECH	23.56	22324799
774	Phosphorylation	KEDSKTSTSVTSVNQ CCCCCCCCCCEECHH	32.23	29899451
775	Phosphorylation	EDSKTSTSVTSVNQA CCCCCCCCCEECHHH	24.14	25521595
777	Phosphorylation	SKTSTSVTSVNQAST CCCCCCCEECHHHCH	27.07	22324799
778	Phosphorylation	KTSTSVTSVNQASTS CCCCCCEECHHHCHH	19.54	25521595
783	Phosphorylation	VTSVNQASTSRLEGL CEECHHHCHHHHHHH	19.70	22324799
784	Phosphorylation	TSVNQASTSRLEGLQ EECHHHCHHHHHHHH	22.38	22324799
792	Phosphorylation	SRLEGLQSENHRLRM HHHHHHHCCCHHHHH	45.46	29899451
800	Ubiquitination	ENHRLRMKITELDKD CCHHHHHHHHHHHCC	39.79	22790023
802	Phosphorylation	HRLRMKITELDKDLE HHHHHHHHHHHCCHH	25.61	20415495
812	Phosphorylation	DKDLEEVTMQLQDTP HCCHHHHHHHHCCCC	11.50	20415495
818	Phosphorylation	VTMQLQDTPEKTTYI HHHHHCCCCCHHCCC	22.01	25521595
822	Phosphorylation	LQDTPEKTTYIKQNH HCCCCCHHCCCCCCC	24.14	20415495
823	Phosphorylation	QDTPEKTTYIKQNHY CCCCCHHCCCCCCCH	34.03	20415495
824	Phosphorylation	DTPEKTTYIKQNHYQ CCCCHHCCCCCCCHH	16.02	20415495
838	Phosphorylation	QELNDILSLGNFTES HHHHHHHHHCCCEEC	34.27	29899451
843	Phosphorylation	ILSLGNFTESTDGGK HHHHCCCEECCCHHH	32.78	29899451
845	Phosphorylation	SLGNFTESTDGGKAI HHCCCEECCCHHHHH	28.83	29899451
846	Phosphorylation	LGNFTESTDGGKAIL HCCCEECCCHHHHHH	32.22	29899451
883	Phosphorylation	DPIEDINSPEHIQRR CCCHHCCCHHHHHHH	31.81	25521595
892	Phosphorylation	EHIQRRLSLQLPILH HHHHHHHHCCCCCCC	16.56	22817900
902	Phosphorylation	LPILHHAYLPSIGGV CCCCCCCCCCCCCCC	18.13	19060867
905	Phosphorylation	LHHAYLPSIGGVDAS CCCCCCCCCCCCCHH	31.13	22807455
912	Phosphorylation	SIGGVDASCVSPCVS CCCCCCHHHCCCCCC	15.58	22817900
915	Phosphorylation	GVDASCVSPCVSPTA CCCHHHCCCCCCCCC	19.53	22817900
919	Phosphorylation	SCVSPCVSPTASPRH HHCCCCCCCCCCCCC	24.21	22817900
921	Phosphorylation	VSPCVSPTASPRHRH CCCCCCCCCCCCCCC	32.06	19060867
923	Phosphorylation	PCVSPTASPRHRHVP CCCCCCCCCCCCCCC	25.58	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
783	S	Phosphorylation	Kinase	AMPKA1	Q5EG47	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GABR2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GABR2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATF4_MOUSE	Atf4	physical	15013631

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.