RAP1A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAP1A_MOUSE
• UniProt AC: P62835
• Protein Name: Ras-related protein Rap-1A
• Gene Name: Rap1a
• Organism: Mus musculus (Mouse).
• Sequence Length: 184
• Subcellular Localization: Cell membrane; Lipid-anchor. Cell junction . Cytoplasm. Cytoplasm, perinuclear region. Early endosome. Late endosome. Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. Colocalized with RAPGEF2 in
• Protein Description: Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (By similarity). Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions..
• Protein Sequence: MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDLEDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKSCLLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Ubiquitination	---MREYKLVVLGSG ---CCEEEEEEECCC	30.01	-
11	Phosphorylation	YKLVVLGSGGVGKSA EEEEEECCCCCCCHH	28.36	28066266
31	Ubiquitination	VQGIFVEKYDPTIED EEEEEEEECCCCCCH	50.04	-
32	Phosphorylation	QGIFVEKYDPTIEDS EEEEEEECCCCCCHH	17.41	29514104
39	Phosphorylation	YDPTIEDSYRKQVEV CCCCCCHHHHHHCEE	17.66	23684622
40	Phosphorylation	DPTIEDSYRKQVEVD CCCCCHHHHHHCEEH	33.86	27717184
48	Glutathionylation	RKQVEVDCQQCMLEI HHHCEEHHHHHHHHH	3.48	24333276
51	Glutathionylation	VEVDCQQCMLEILDT CEEHHHHHHHHHHHH	1.07	24333276
117	Ubiquitination	PMILVGNKCDLEDER CEEEECCCCCCCCCE	24.17	-
118	S-nitrosocysteine	MILVGNKCDLEDERV EEEECCCCCCCCCEE	9.29	-
118	S-nitrosylation	MILVGNKCDLEDERV EEEECCCCCCCCCEE	9.29	21278135
128	Ubiquitination	EDERVVGKEQGQNLA CCCEECCHHHHHHHH	34.94	-
128	Malonylation	EDERVVGKEQGQNLA CCCEECCHHHHHHHH	34.94	26320211
141	Glutathionylation	LARQWCNCAFLESSA HHHHHHCHHHHHHHC	2.28	24333276
149	Ubiquitination	AFLESSAKSKINVNE HHHHHHCCCCCCHHH	54.98	-
150	Phosphorylation	FLESSAKSKINVNEI HHHHHCCCCCCHHHH	38.18	21082442
151	Ubiquitination	LESSAKSKINVNEIF HHHHCCCCCCHHHHH	37.28	-
159	Phosphorylation	INVNEIFYDLVRQIN CCHHHHHHHHHHHHH	17.65	22817900
181	Geranylgeranylation	KKPKKKSCLLL---- CCCCCCCCCCC----	4.22	-
181	Methylation	KKPKKKSCLLL---- CCCCCCCCCCC----	4.22	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RAP1A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RAP1A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAP1A_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RAP1A_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.